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Found 319 with Last Name = 'khalil' and Initial = 'e'
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50074092(6'-oxo-1-[(2S)-tetrahydro-1H-2-pyrrolylcarbonyl]-(...)
Affinity DataKi:  0.0310nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601((E)-6-(3-oxo-3-phenylprop-1-enyl)pyrimidine-2,4(1H...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50074093((2R,3'S,8a'R)-5'-oxo-1-((S)-pyrrolidine-2-carbonyl...)
Affinity DataKi:  0.0500nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601((E)-6-(3-oxo-3-phenylprop-1-enyl)pyrimidine-2,4(1H...)
Affinity DataKi:  0.0600nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50074092(6'-oxo-1-[(2S)-tetrahydro-1H-2-pyrrolylcarbonyl]-(...)
Affinity DataKi:  0.0640nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50074093((2R,3'S,8a'R)-5'-oxo-1-((S)-pyrrolidine-2-carbonyl...)
Affinity DataKi:  0.0670nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50074092(6'-oxo-1-[(2S)-tetrahydro-1H-2-pyrrolylcarbonyl]-(...)
Affinity DataKi:  0.0710nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50074093((2R,3'S,8a'R)-5'-oxo-1-((S)-pyrrolidine-2-carbonyl...)
Affinity DataKi:  0.0900nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601((E)-6-(3-oxo-3-phenylprop-1-enyl)pyrimidine-2,4(1H...)
Affinity DataKi:  0.0900nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50074092(6'-oxo-1-[(2S)-tetrahydro-1H-2-pyrrolylcarbonyl]-(...)
Affinity DataKi:  0.122nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601((E)-6-(3-oxo-3-phenylprop-1-enyl)pyrimidine-2,4(1H...)
Affinity DataKi:  0.130nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50074093((2R,3'S,8a'R)-5'-oxo-1-((S)-pyrrolidine-2-carbonyl...)
Affinity DataKi:  0.196nMAssay Description:Inhibitor constant of compound for high affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50182163(4-[7-bromo-1-(2,5-difluoro-benzyl)-1H-benzoimidazo...)
Affinity DataKi:  10nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50233679(CHEMBL399284 | N-[3'-(5-carbamimidoyl-2-methylsulf...)
Affinity DataKi:  14nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50182160(4-[7-bromo-1-(2,6-dichloro-benzyl)-1H-benzoimidazo...)
Affinity DataKi:  20nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50233691(4-(2'-amino-6'-methyl-biphenyl-3-sulfonyl)-5-methy...)
Affinity DataKi:  20nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50233674(6-{3-[3'-(5-carbamimidoyl-2-methylsulfanyl-thiophe...)
Affinity DataKi:  22nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50182171(4-(1-benzyl-7-bromo-1H-benzoimidazole-5-sulfonyl)-...)
Affinity DataKi:  30nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50182170(4-[7-bromo-1-(2-fluoro-5-nitro-benzyl)-1H-benzoimi...)
Affinity DataKi:  30nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50233686(4-(2'-methyl-biphenyl-3-sulfonyl)-5-methylsulfanyl...)
Affinity DataKi:  30nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50233692(4-[3-(6-methyl-pyridin-2-yl)-benzenesulfonyl]-5-me...)
Affinity DataKi:  40nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50182159(4-[7-bromo-1-(2,6-difluoro-benzyl)-1H-benzoimidazo...)
Affinity DataKi:  40nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50233688(4-(2'-chloro-biphenyl-3-sulfonyl)-5-methylsulfanyl...)
Affinity DataKi:  40nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50233694(5-[3'-(5-carbamimidoyl-2-methylsulfanyl-thiophene-...)
Affinity DataKi:  42nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50182176(4-[7-bromo-1-(3-methyl-but-2-enyl)-1H-benzoimidazo...)
Affinity DataKi:  50nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50233677(4-(2'-hydroxymethyl-6'-methyl-biphenyl-3-sulfonyl)...)
Affinity DataKi:  50nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147047(5-Methylsulfanyl-4-[4-(1-phenyl-5-propyl-1H-pyrazo...)
Affinity DataKi:  60nMAssay Description:In vitro binding affinity towards human Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601((E)-6-(3-oxo-3-phenylprop-1-enyl)pyrimidine-2,4(1H...)
Affinity DataKi:  60nMAssay Description:Inhibitor constant of compound for low affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601((E)-6-(3-oxo-3-phenylprop-1-enyl)pyrimidine-2,4(1H...)
Affinity DataKi:  60nMAssay Description:Inhibitor constant of compound for low affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601((E)-6-(3-oxo-3-phenylprop-1-enyl)pyrimidine-2,4(1H...)
Affinity DataKi:  60.1nMAssay Description:Inhibitor constant of compound for low affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of G...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50233689(5-methylsulfanyl-4-(6'-methyl-2'-{3-[2-(2H-tetrazo...)
Affinity DataKi:  64nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataKi:  70nMAssay Description:In vitro binding affinity towards human Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50182185(4-(1-allyl-7-bromo-1H-benzoimidazole-5-sulfonyl)-5...)
Affinity DataKi:  70nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50060601((E)-6-(3-oxo-3-phenylprop-1-enyl)pyrimidine-2,4(1H...)
Affinity DataKi:  73.2nMAssay Description:Inhibitor constant of compound for low affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of G...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147059(4-[4-(5-Ethoxy-1-phenyl-1H-pyrazol-4-yl)-thiazol-2...)
Affinity DataKi:  90nMAssay Description:In vitro binding affinity towards human Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50182183(4-[7-chloro-3-(2,6-difluoro-benzyl)-3H-benzoimidaz...)
Affinity DataKi:  100nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50182173(4-[7-chloro-1-(2,6-difluoro-benzyl)-1H-benzoimidaz...)
Affinity DataKi:  100nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50233693(CHEMBL252619 | N-[3'-(5-carbamimidoyl-2-methylsulf...)
Affinity DataKi:  120nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50233680(4-(2'-hydroxymethyl-biphenyl-3-sulfonyl)-5-methyls...)
Affinity DataKi:  120nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50233681(5-methylsulfanyl-4-(2'-vinyl-biphenyl-3-sulfonyl)-...)
Affinity DataKi:  140nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50233676(3'-(5-carbamimidoyl-2-methylsulfanyl-thiophene-3-s...)
Affinity DataKi:  150nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147054(5-Methylsulfanyl-4-[4-(1-phenyl-1H-pyrazol-4-yl)-t...)
Affinity DataKi:  150nMAssay Description:In vitro binding affinity towards human Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50233683(4-(3'-hydroxy-biphenyl-3-sulfonyl)-5-methylsulfany...)
Affinity DataKi:  150nMAssay Description:Inhibition of Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50182164(4-[7-bromo-3-(2,6-dichloro-benzyl)-3H-benzoimidazo...)
Affinity DataKi:  160nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50074092(6'-oxo-1-[(2S)-tetrahydro-1H-2-pyrrolylcarbonyl]-(...)
Affinity DataKi:  168nMAssay Description:Inhibitor constant of compound for low affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of G...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50182181(4-[7-bromo-3-(2,6-difluoro-benzyl)-3H-benzoimidazo...)
Affinity DataKi:  170nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50182174(4-[7-bromo-3-(2-fluoro-5-nitro-benzyl)-3H-benzoimi...)
Affinity DataKi:  170nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataKi:  180nMAssay Description:In vitro binding affinity towards trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50182180(4-(7-bromo-3-phenyl-3H-benzoimidazole-5-sulfonyl)-...)
Affinity DataKi:  180nMAssay Description:Inhibition of C1SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50074093((2R,3'S,8a'R)-5'-oxo-1-((S)-pyrrolidine-2-carbonyl...)
Affinity DataKi:  188nMAssay Description:Inhibitor constant of compound for low affinity component of [3H]-spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of G...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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