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Found 611 with Last Name = 'kim' and Initial = 'es'
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154039(2-Amino-1-[3-(5-bromo-4-phenyl-1H-imidazol-2-yl)-3...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50017698(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154035((S)-2-amino-3-(4-hydroxyphenyl)-1-((S)-3-(5-methyl...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154035((S)-2-amino-3-(4-hydroxyphenyl)-1-((S)-3-(5-methyl...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154036((S)-2-amino-3-(4-hydroxyphenyl)-1-((S)-3-(4-phenyl...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154041((S)-2-amino-3-(4-hydroxyphenyl)-1-((S)-2-(5-methyl...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154042(2-[2-Amino-3-(4-hydroxy-phenyl)-propionyl]-1,2,3,4...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154039(2-Amino-1-[3-(5-bromo-4-phenyl-1H-imidazol-2-yl)-3...)
Affinity DataKi:  12nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154040(2-Amino-1-[3-(1H-benzoimidazol-2-yl)-3,4-dihydro-1...)
Affinity DataKi:  15.1nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154040(2-Amino-1-[3-(1H-benzoimidazol-2-yl)-3,4-dihydro-1...)
Affinity DataKi:  15.1nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154035((S)-2-amino-3-(4-hydroxyphenyl)-1-((S)-3-(5-methyl...)
Affinity DataKi:  20.7nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154035((S)-2-amino-3-(4-hydroxyphenyl)-1-((S)-3-(5-methyl...)
Affinity DataKi:  20.7nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154041((S)-2-amino-3-(4-hydroxyphenyl)-1-((S)-2-(5-methyl...)
Affinity DataKi:  22nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154037(2-Amino-3-(4-hydroxy-phenyl)-1-[2-(5-methyl-4-phen...)
Affinity DataKi:  23nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50017698(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N...)
Affinity DataKi:  50nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154036((S)-2-amino-3-(4-hydroxyphenyl)-1-((S)-3-(4-phenyl...)
Affinity DataKi:  55nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154042(2-[2-Amino-3-(4-hydroxy-phenyl)-propionyl]-1,2,3,4...)
Affinity DataKi:  69nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154034(2-Amino-3-(4-hydroxy-phenyl)-1-[3-(5-methyl-4-prop...)
Affinity DataKi: >100nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154037(2-Amino-3-(4-hydroxy-phenyl)-1-[2-(5-methyl-4-phen...)
Affinity DataKi: >100nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154034(2-Amino-3-(4-hydroxy-phenyl)-1-[3-(5-methyl-4-prop...)
Affinity DataKi: >100nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154038(2-Amino-1-[2-(4-propyl-1H-imidazol-2-yl)-2,3-dihyd...)
Affinity DataKi: >100nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154040(2-Amino-1-[3-(1H-benzoimidazol-2-yl)-3,4-dihydro-1...)
Affinity DataKi: >100nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154040(2-Amino-1-[3-(1H-benzoimidazol-2-yl)-3,4-dihydro-1...)
Affinity DataKi: >100nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154034(2-Amino-3-(4-hydroxy-phenyl)-1-[3-(5-methyl-4-prop...)
Affinity DataKi: >100nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154034(2-Amino-3-(4-hydroxy-phenyl)-1-[3-(5-methyl-4-prop...)
Affinity DataKi: >100nMAssay Description:Binding affinity for delta opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154038(2-Amino-1-[2-(4-propyl-1H-imidazol-2-yl)-2,3-dihyd...)
Affinity DataKi: >100nMAssay Description:Binding affinity for Mu opioid receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50154036((S)-2-amino-3-(4-hydroxyphenyl)-1-((S)-3-(4-phenyl...)
Affinity DataKi:  124nMAssay Description:Binding affinity for kappa opioid receptor of guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM16839((2S)-3-{4-[(3,5-dichloropyridine-4-)amido]phenyl}-...)
Affinity DataIC50:  0.600nMT: 2°CAssay Description:M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419721(US10464919, Example 59)
Affinity DataIC50:  0.920nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419799(US10464919, Example 137)
Affinity DataIC50:  0.950nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM16843((2S)-3-{4-[(3,5-dichloropyridine-4-)amido]phenyl}-...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description: Immulon 96-well plates were coated with recombinant hVCAM-1 overnight at 4 C. Plates were washed and blocked for 1 h at room temperature in PBS-BSA....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419844(US10464919, Example 182)
Affinity DataIC50:  1.26nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419794(US10464919, Example 132)
Affinity DataIC50:  1.31nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419731(US10464919, Example 69)
Affinity DataIC50:  1.32nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TNK1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419721(US10464919, Example 59)
Affinity DataIC50:  1.37nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419781(US10464919, Example 119)
Affinity DataIC50:  1.38nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419751(US10464919, Example 89)
Affinity DataIC50:  1.48nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419791(US10464919, Example 129)
Affinity DataIC50:  1.65nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419797(US10464919, Example 135)
Affinity DataIC50:  1.75nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419758(US10464919, Example 96)
Affinity DataIC50:  1.75nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419740(US10464919, Example 78)
Affinity DataIC50:  1.87nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419721(US10464919, Example 59)
Affinity DataIC50:  1.95nMAssay Description:The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419832(US10464919, Example 170)
Affinity DataIC50:  1.96nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419755(US10464919, Example 93)
Affinity DataIC50:  1.97nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Je Il Pharmaceutical

US Patent
LigandPNGBDBM419761(US10464919, Example 99)
Affinity DataIC50:  1.99nMAssay Description:The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM50372987(CHEMBL258255)
Affinity DataIC50:  2nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM16809((2S)-2-[(2,6-dichlorophenyl)formamido]-3-{4-[2-(2-...)
Affinity DataIC50:  2nMT: 2°CAssay Description:M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM16810((2S)-2-[(2,6-dichlorophenyl)formamido]-3-(4-{5-met...)
Affinity DataIC50:  2nMT: 2°CAssay Description:M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM16812((2S)-2-[(2,6-dichlorophenyl)formamido]-3-[4-(5-eth...)
Affinity DataIC50:  2nMT: 2°CAssay Description:M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM16817((2S)-2-[(2,6-dichlorophenyl)formamido]-3-{4-[5-(2-...)
Affinity DataIC50:  2nMT: 2°CAssay Description:M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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