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Found 2046 with Last Name = 'kiselyov' and Initial = 'as'
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50201397(1-methyl-N-(3-methyl-4-(trifluoromethyl)phenyl)-4-...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of VEGFR2 by [32P]ATP-competitive radioassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50201363(1-methyl-4-(pyridin-4-ylmethylamino)-N-(4-(trifluo...)
Affinity DataKi:  0.170nMAssay Description:Inhibition of VEGFR2 by [32P]ATP-competitive radioassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50201394(CHEMBL393779 | N-(4-tert-butylphenyl)-1-methyl-4-(...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of VEGFR2 by [32P]ATP-competitive radioassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.300nMAssay Description:Displacement of E2-Alexa633 from GFP-tagged ERalpha expressed in COS7 cells by FACSMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.380nMAssay Description:Displacement of E2-Alexa633 from GFP-tagged ERbeta expressed in COS7 cells by FACSMore data for this Ligand-Target Pair
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
University Of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  5.70nMAssay Description:Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
University Of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50303803(1-((3aS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl...)
Affinity DataKi:  11nMAssay Description:Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211992(CHEMBL236419 | N-(4-(chlorodifluoromethoxy)phenyl)...)
Affinity DataKi:  70nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50277407(CHEMBL473288 | N-(4-bromophenyl)-4-(pyridin-4-ylme...)
Affinity DataKi:  70nMAssay Description:Inhibition of VEGFR2 (unknown origin) at IC90 concentration by ATP based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211983(1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethoxy)p...)
Affinity DataKi:  80nMAssay Description:Displacement of [32P]ATP from human VEGFR2 after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50248494(CHEMBL490968 | N-(Pyridin-4-ylmethyl)-2-(1-(3-(tri...)
Affinity DataKi:  80nMAssay Description:Binding affinity to VEGFR2 (unknown origin) at IC90 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211992(CHEMBL236419 | N-(4-(chlorodifluoromethoxy)phenyl)...)
Affinity DataKi:  90nMAssay Description:Displacement of [32P]ATP from human VEGFR2 after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211983(1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethoxy)p...)
Affinity DataKi:  90nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211976(CHEMBL397323 | N-(4-chlorophenyl)-1-(2-(pyridin-4-...)
Affinity DataKi:  90nMAssay Description:Displacement of [32P]ATP from human VEGFR2 after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50277407(CHEMBL473288 | N-(4-bromophenyl)-4-(pyridin-4-ylme...)
Affinity DataKi:  90nMAssay Description:Inhibition of VEGFR2 (unknown origin) at IC50 concentration by ATP based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50248494(CHEMBL490968 | N-(Pyridin-4-ylmethyl)-2-(1-(3-(tri...)
Affinity DataKi:  90nMAssay Description:Binding affinity to VEGFR2 (unknown origin) at IC50 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50248491(2-(1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl)-N-(py...)
Affinity DataKi:  110nMAssay Description:Binding affinity to VEGFR2 (unknown origin) at IC90 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211976(CHEMBL397323 | N-(4-chlorophenyl)-1-(2-(pyridin-4-...)
Affinity DataKi:  110nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50277363(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)
Affinity DataKi:  120nMAssay Description:Inhibition of VEGFR2 (unknown origin) at IC90 concentration by ATP based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50248491(2-(1-(3-Chlorophenyl)-1H-1,2,3-triazol-4-yl)-N-(py...)
Affinity DataKi:  120nMAssay Description:Binding affinity to VEGFR2 (unknown origin) at IC50 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50277363(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)
Affinity DataKi:  130nMAssay Description:Inhibition of VEGFR2 (unknown origin) at IC50 concentration by ATP based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211979(CHEMBL399605 | N-(4-tert-butylphenyl)-1-(2-(pyridi...)
Affinity DataKi:  130nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50277281(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)...)
Affinity DataKi:  130nMAssay Description:Inhibition of VEGFR2 (unknown origin) at IC90 concentration by ATP based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50248584(2-(1-(3-isopropylphenyl)-1H-1,2,3-triazol-4-yl)-N-...)
Affinity DataKi:  140nMAssay Description:Binding affinity to VEGFR2 (unknown origin) at IC90 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211979(CHEMBL399605 | N-(4-tert-butylphenyl)-1-(2-(pyridi...)
Affinity DataKi:  140nMAssay Description:Displacement of [32P]ATP from human VEGFR2 after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211972(CHEMBL233823 | N-(3-chloro-4-(trifluoromethyl)phen...)
Affinity DataKi:  160nMAssay Description:Displacement of [32P]ATP from human VEGFR2 after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50248584(2-(1-(3-isopropylphenyl)-1H-1,2,3-triazol-4-yl)-N-...)
Affinity DataKi:  160nMAssay Description:Binding affinity to VEGFR2 (unknown origin) at IC50 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50277281(4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)...)
Affinity DataKi:  160nMAssay Description:Inhibition of VEGFR2 (unknown origin) at IC50 concentration by ATP based competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chemical Diversity

Curated by ChEMBL
LigandPNGBDBM50211972(CHEMBL233823 | N-(3-chloro-4-(trifluoromethyl)phen...)
Affinity DataKi:  170nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50303803(1-((3aS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of E2-Alexa633 from GFP-tagged ERalpha expressed in COS7 cells by FACSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50324674(1-((3aS,4S,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of E2-Alexa633 from GFP-tagged ERalpha expressed in COS7 cells by FACSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315482(CHEMBL1093897 | N-(3-chlorophenylsulfonyl)-3-(3,3-...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315493(3-(1-(2,4-dichlorobenzyl)-2-oxoindolin-7-yl)-N-(2,...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315480(3-(3,3-difluoro-1-(naphthalen-2-ylmethyl)-2-oxoind...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315471(3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindoli...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315474(CHEMBL1089095 | N-(3-chlorophenylsulfonyl)-3-(1-(2...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315473(3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindoli...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315472(3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindoli...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254766(2-(3-(2,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315476(3-(1-(2,4-dichlorobenzyl)-3,3-difluoro-2-oxoindoli...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254687(CHEMBL464032 | N-(4,5-dichlorothiophen-2-ylsulfony...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254841(2-(3-(3,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at human EP3 receptor assessed as cAMP production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315503(CHEMBL1092871 | N-(3,4-dichlorophenylsulfonyl)-3-(...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315498(3-(1-(naphthalen-2-ylmethyl)-2-oxoindolin-7-yl)-N-...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315481(CHEMBL1090222 | N-(3,4-dichlorophenylsulfonyl)-3-(...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315479(3-(3,3-difluoro-1-(naphthalen-2-ylmethyl)-2-oxoind...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315528(3-(3-methyl-1-(naphthalen-2-ylmethyl)-2-oxoindolin...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315499(CHEMBL1088822 | N-(3,4-difluorophenylsulfonyl)-3-(...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315529(CHEMBL1089454 | N-(3-chlorophenylsulfonyl)-3-(3-me...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50315506(CHEMBL1091146 | N-(4,5-dichlorothiophen-2-ylsulfon...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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