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Found 102 with Last Name = 'klatt' and Initial = 't'
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325767(3-(2'-chlorobiphenyl-3-yl)-1H-pyrazole-1-carboxami...)
Affinity DataKi:  0.0180nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325766(3-(2'-chlorobiphenyl-4-yl)-1H-pyrazole-1-carboxami...)
Affinity DataKi:  0.111nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325765(3-(4-(4-chloro-2-fluorophenoxy)phenyl)-1H-pyrazole...)
Affinity DataKi:  13nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataKi:  15nMAssay Description:Inhibition of human Nav 1.7 channel by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325819((Z)-5-((2'-(trifluoromethoxy)biphenyl-3-yl)methyle...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human Nav1.7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataKi:  230nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325762(1-(2',4'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataKi:  340nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141073((E)-2-(4-(4-fluorophenoxy)benzylidene)hydrazinecar...)
Affinity DataKi:  360nMAssay Description:Binding affinity to human Nav1.7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332656(CHEMBL1631089 | ethyl 3-carbamoyl-1-(2'-(trifluoro...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataIC50:  15nMAssay Description:Blockade of human Nav1.7 by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332657(CHEMBL1631090 | N5-ethyl-1-(2'-(trifluoromethoxy)b...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325779(1-(2',6'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332649(1-(5'-fluoro-2'-(2,2,3,3,3-pentafluoropropoxy)biph...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332652(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325805(4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-imidazole...)
Affinity DataIC50: <50nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325805(4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-imidazole...)
Affinity DataIC50: <50nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325818(2-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-4-c...)
Affinity DataIC50:  50nMAssay Description:Blockade of human Nav1.7 by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325805(4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-imidazole...)
Affinity DataIC50: <50nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332650(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325769(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50:  65nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325778(1-(2'-fluoro-6'-(trifluoromethyl)biphenyl-3-yl)-5-...)
Affinity DataIC50:  71nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332662(1-(4'-fluoro-2'-(2,2,3,3,3-pentafluoropropoxy)biph...)
Affinity DataIC50:  106nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332647(1-(2'-fluoro-6'-(trifluoromethoxy)biphenyl-3-yl)-1...)
Affinity DataIC50:  106nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325770(5-amino-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-...)
Affinity DataIC50:  111nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332654(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50:  115nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325781(5-methyl-1-(2'-(2,2,3,3,3-pentafluoropropoxy)biphe...)
Affinity DataIC50:  128nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332655(1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H-pyrazole...)
Affinity DataIC50:  132nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332651(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)
Affinity DataIC50:  147nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332649(1-(5'-fluoro-2'-(2,2,3,3,3-pentafluoropropoxy)biph...)
Affinity DataIC50:  149nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325805(4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-imidazole...)
Affinity DataIC50:  150nMAssay Description:Blockade of human Nav1.7 by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332659(1-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-pyrazole-...)
Affinity DataIC50:  155nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325782(1-(6-fluoro-2'-(trifluoromethoxy)biphenyl-3-yl)-5-...)
Affinity DataIC50:  162nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325774(5-methyl-1-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-...)
Affinity DataIC50:  163nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332653(5-methyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)
Affinity DataIC50:  185nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325780(5-methyl-1-(2'-(2,2,2-trifluoroethoxy)biphenyl-3-y...)
Affinity DataIC50:  187nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332658(1-(2',3'-dichlorobiphenyl-3-yl)-1H-pyrazole-3,5-di...)
Affinity DataIC50:  195nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332650(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)
Affinity DataIC50:  203nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325783(1-(4-fluoro-2'-(trifluoromethoxy)biphenyl-3-yl)-5-...)
Affinity DataIC50:  222nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325771(5-methyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)
Affinity DataIC50:  224nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325771(5-methyl-1-(2'-(trifluoromethoxy)biphenyl-3-yl)-1H...)
Affinity DataIC50:  224nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325764(4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-2-c...)
Affinity DataIC50:  230nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325776(1-(4'-chloro-2'-(trifluoromethyl)biphenyl-3-yl)-5-...)
Affinity DataIC50:  243nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325818(2-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole-4-c...)
Affinity DataIC50:  260nMAssay Description:Blockade of human Nav1.7 by voltage ion probe reader based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325817(4-(2'-(trifluoromethyl)biphenyl-3-yl)-1H-imidazole...)
Affinity DataIC50:  270nMAssay Description:Blockade of human Nav1.7 by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325763(1-(2',5'-bis(trifluoromethyl)biphenyl-3-yl)-5-meth...)
Affinity DataIC50:  272nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332646(1-(2'-fluoro-3'-(trifluoromethoxy)biphenyl-3-yl)-1...)
Affinity DataIC50:  282nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332651(1-(2'-(2,2,3,3,3-pentafluoropropoxy)-3'-(trifluoro...)
Affinity DataIC50:  299nMAssay Description:Inhibition of human Nav1.8 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332648(1-(2'-(trifluoromethoxy)-5'-(trifluoromethyl)biphe...)
Affinity DataIC50:  325nMAssay Description:Inhibition of human Nav1.7 by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325784(1-(2',6-bis(trifluoromethoxy)biphenyl-3-yl)-5-meth...)
Affinity DataIC50:  373nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325777(1-(5'-fluoro-2'-(trifluoromethyl)biphenyl-3-yl)-5-...)
Affinity DataIC50:  412nMAssay Description:Inhibition of human Nav 1.7 channel by voltage-ion-probe-readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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