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Found 762 with Last Name = 'kleemann' and Initial = 'h'
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045686(4-(4-Amino-piperidin-1-yl)-N-[1-(1-cyclohexylmethy...)
Affinity DataIC50:  0.130nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045691(CHEMBL94827 | Methyl-{2-[methyl-(morpholine-4-carb...)
Affinity DataIC50:  0.160nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045691(CHEMBL94827 | Methyl-{2-[methyl-(morpholine-4-carb...)
Affinity DataIC50:  0.160nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045687(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-...)
Affinity DataIC50:  0.170nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  0.240nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045685(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  0.25nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045685(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  0.260nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045692(3-(4-Amino-cyclohexanesulfonyl)-2-benzyl-N-[1-(1-c...)
Affinity DataIC50:  0.310nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045692(3-(4-Amino-cyclohexanesulfonyl)-2-benzyl-N-[1-(1-c...)
Affinity DataIC50:  0.310nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045693(4-Amino-piperidine-1-carboxylic acid 1-[1-(1-cyclo...)
Affinity DataIC50:  0.370nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045693(4-Amino-piperidine-1-carboxylic acid 1-[1-(1-cyclo...)
Affinity DataIC50:  0.370nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  0.380nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045683(4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cycloh...)
Affinity DataIC50:  0.390nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045687(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-...)
Affinity DataIC50:  0.430nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045681(4-Amino-cyclohexanecarboxylic acid {1-[1-(1-cycloh...)
Affinity DataIC50:  0.470nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM269143(US9718825, Example 589)
Affinity DataIC50: <0.5nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM269150(US9718825, Example 596)
Affinity DataIC50: <0.5nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045681(4-Amino-cyclohexanecarboxylic acid {1-[1-(1-cycloh...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM269083(US9718825, Example 527)
Affinity DataIC50: <0.510nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268829(US9718825, Example 234)
Affinity DataIC50: <0.510nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045684(3-(4-Amino-piperidine-1-sulfonyl)-2-benzyl-N-[1-(1...)
Affinity DataIC50:  0.540nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM269008(US9718825, Example 451)
Affinity DataIC50:  0.570nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268860(US9718825, Example 265)
Affinity DataIC50:  0.590nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045682(2-[4-(4-Amino-piperidin-1-yl)-2-benzyl-4-oxo-butyr...)
Affinity DataIC50:  0.680nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045688(5-{1-[1-(1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridi...)
Affinity DataIC50:  0.690nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045684(3-(4-Amino-piperidine-1-sulfonyl)-2-benzyl-N-[1-(1...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045688(5-{1-[1-(1-Cyclohexylmethyl-2,3-dihydroxy-5-pyridi...)
Affinity DataIC50:  0.75nMAssay Description:Selectivity against rhesus monkey plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268850(US9718825, Example 255 | US9718825, Example 261)
Affinity DataIC50:  0.760nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045686(4-(4-Amino-piperidin-1-yl)-N-[1-(1-cyclohexylmethy...)
Affinity DataIC50:  0.790nMAssay Description:In vitro inhibition of purified human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268828(US9718825, Example 233)
Affinity DataIC50:  0.850nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268875(US9718825, Example 300)
Affinity DataIC50:  1.10nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268847(US9718825, Example 252)
Affinity DataIC50:  1.10nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045690(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-...)
Affinity DataIC50:  1.10nMAssay Description:Selectivity against guinea pig plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM269092(US9718825, Example 537)
Affinity DataIC50:  1.10nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRenin(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50045690(2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibition of renin in human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268698(US9718825, Example 100)
Affinity DataIC50:  1.10nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268644(US9718825, Example 46)
Affinity DataIC50: <1.20nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268648(US9718825, Example 50)
Affinity DataIC50: <1.20nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268649(US9718825, Example 51)
Affinity DataIC50: <1.20nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268650(US9718825, Example 52)
Affinity DataIC50: <1.20nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268659(US9718825, Example 61)
Affinity DataIC50: <1.20nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268660(US9718825, Example 62)
Affinity DataIC50: <1.20nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM50043018(CHEMBL3355028 | US9718825, Example 63)
Affinity DataIC50: <1.20nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM269021(US9718825, Example 464)
Affinity DataIC50: <1.20nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268619(US9718825, Example 15)
Affinity DataIC50: <1.20nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268620(US9718825, Example 16)
Affinity DataIC50: <1.20nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268621(US9718825, Example 17)
Affinity DataIC50: <1.20nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268626(US9718825, Example 23)
Affinity DataIC50: <1.20nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268627(US9718825, Example 24)
Affinity DataIC50: <1.20nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM268628(US9718825, Example 25)
Affinity DataIC50: <1.20nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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