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Found 1121 with Last Name = 'knox' and Initial = 'r'
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50206243(CHEMBL3918431)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50235306(CHEMBL4084621)
Affinity DataKi:  3.30nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma counting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50206243(CHEMBL3918431)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I]Tyr54-alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes co-expressing human RIC3 measured after 2 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50206243(CHEMBL3918431)
Affinity DataKi:  4.80nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma counting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50235306(CHEMBL4084621)
Affinity DataKi:  8.10nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50211195(CHEMBL3944506)
Affinity DataKi:  38nMAssay Description:Displacement of [125I]Tyr54-alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes co-expressing human RIC3 measured after 2 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50164613((-)-Spiro[1-azabicyclo(2.2.2)octane-3,5'-oxazolidi...)
Affinity DataKi:  92nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat hippocampal alpha7 nAChR measured after 2 hrs by TopCount scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50260153(Apamin | CHEMBL525408 | Octadecapeptide venom)
Affinity DataIC50:  0.0640nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50260153(Apamin | CHEMBL525408 | Octadecapeptide venom)
Affinity DataIC50:  0.0640nMAssay Description:Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50260153(Apamin | CHEMBL525408 | Octadecapeptide venom)
Affinity DataIC50:  0.168nMAssay Description:Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50260153(Apamin | CHEMBL525408 | Octadecapeptide venom)
Affinity DataIC50:  0.168nMAssay Description:Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191378(CHEMBL212163 | sodium (R,E)-6-((6,8-dihydro-5H-imi...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Escherichia coli TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191379((5R)(6Z)-6-(6,7-dihydro-4H-pyrazolo[5,1-c][1,4]-th...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Escherichia coli TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191377((5R),(6Z)-7-oxo-6-(4,5,6,7-tetrahydropyrazolo[1,5-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Escherichia coli TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191390((5R),(6Z)-6-(5,5-dioxo-4,5,6,7-tetrahydro-5'6-pyra...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Escherichia coli TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157688((5R,6Z)-6-[(7-methylimidazo[2,1-b][1,3]-benzothiaz...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149467((5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Escherichia coli TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157689((5R,6Z)-6-(imidazo[2,1-b][1,3]benzothiazol-2-ylmet...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191379((5R)(6Z)-6-(6,7-dihydro-4H-pyrazolo[5,1-c][1,4]-th...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191389(6-(6,7-dihydro-4H-thieno[3,2-c]pyran-2-ylmethylene...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Escherichia coli TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM429525(3-(5-Chloro-6-isobutoxypyridin-3-yl)-5-fluoro-1-me...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293 cells at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Rattus norvegicus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50237517(CHEMBL4078268 | US10836758, Example 20)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of Nav1.7 in C57BL/6 rat embryonic DRG cells assessed as blockade of spontaneous neuronal firing by Maestro microelectrode array analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of Nav1.7 in mouse DRG neurons at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157694((5R,6Z)-6-[(7-fluoroimidazo[2,1-b][1,3]-benzothiaz...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157687((5R,6Z)-6-[(5-methylimidazo[2,1-b][1,3]-benzothiaz...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149467((5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191383((5R),(6Z)-6-(5,6-dihydro-8H-imidazo[2,1-c]-[1,4]th...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191390((5R),(6Z)-6-(5,5-dioxo-4,5,6,7-tetrahydro-5'6-pyra...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191386((5R)(6Z)-7-oxo-6-(4,5,6,7-tetrahydropyrazolo-[1,5-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Escherichia coli TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157691((5R,6Z)-6-[(7-methoxyimidazo[2,1-b][1,3]-benzothia...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191381((5R,6Z)-6-{[5-(4-methoxybenzyl)-4,5,6,7-tetrahydro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Escherichia coli TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50024245(CHEMBL3325524)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293 cells assessed as reduction in peak inward current at -60 mV holding potential measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human Nav1.5 inactivated state form expressed in HEK293 cells at -60 mV holding potential by by automated patch clamp electrophysiology...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191386((5R)(6Z)-7-oxo-6-(4,5,6,7-tetrahydropyrazolo-[1,5-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157693((5R,6Z)-6-[(7-chloroimidazo[2,1-b][1,3]-benzothiaz...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157688((5R,6Z)-6-[(7-methylimidazo[2,1-b][1,3]-benzothiaz...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Escherichia coli TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191377((5R),(6Z)-7-oxo-6-(4,5,6,7-tetrahydropyrazolo[1,5-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191383((5R),(6Z)-6-(5,6-dihydro-8H-imidazo[2,1-c]-[1,4]th...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Escherichia coli TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM429526(3-(5-Chloro-6-isobutoxypyridin-3-yl)-N-(cyclopropy...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293 cells at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50232609(CHEMBL4098776)
Affinity DataIC50:  3.80nMAssay Description:Antagonist activity at human 5HT3A receptor assessed as inhibition of 5-HT-induced calcium influx by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of recombinant mouse Nav1.7 expressed in HEK293 cells at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50263327(CHEMBL476339 | N-(4-methylpyridin-2-yl)-4-(pyridin...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50237517(CHEMBL4078268 | US10836758, Example 20)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293 cells assessed as reduction in peak inward current at -70 mV holding potential measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191385((5R,6Z)-6-(6,7-dihydro-4H-pyrazolo[5,1-c]-[1,4]oxa...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Escherichia coli TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191389(6-(6,7-dihydro-4H-thieno[3,2-c]pyran-2-ylmethylene...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase TEM(Escherichia coli)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191387((5R),(6Z)-6-(7-methyl-5,6,7,8-tetrahydroimidazo[1,...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Escherichia coli TEM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50263327(CHEMBL476339 | N-(4-methylpyridin-2-yl)-4-(pyridin...)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]apamin from Kca2.3 channel expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50465061(CHEMBL4290933 | US10550080, Example 47)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293 cells at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191388((5R)(6Z)-6-(6,7-5H-dihydropyrazolo[5,1-b]-oxazin-2...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-lactamase(Enterobacter cloacae)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191378(CHEMBL212163 | sodium (R,E)-6-((6,8-dihydro-5H-imi...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Enterobacter cloacae AmpCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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