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Found 83 with Last Name = 'komiya' and Initial = 'm'
TargetNeutrophil elastase(Homo sapiens (Human))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109771(3-{4-[(1-{2-[1-(Benzooxazole-2-carbonyl)-2-methyl-...)
Affinity DataIC50:  3.5nMAssay Description:In vitro inhibition of the human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate Suc-Ala-Pro-Ala-MCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109757(CHEMBL355937 | {2-[(1-{2-[1-(Benzooxazole-2-carbon...)
Affinity DataIC50:  7.20nMAssay Description:In vitro inhibition of the human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate Suc-Ala-Pro-Ala-MCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109765(CHEMBL357495 | [4-(1-{2-[1-(Benzooxazole-2-carbony...)
Affinity DataIC50:  7.40nMAssay Description:In vitro inhibition of the human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate Suc-Ala-Pro-Ala-MCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109777(CHEMBL118176 | {4-[((R)-1-{(S)-2-[(S)-1-(Benzooxaz...)
Affinity DataIC50:  7.60nMAssay Description:In vitro inhibition of the human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate Suc-Ala-Pro-Ala-MCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109761(2,2-Dimethyl-propionic acid (S)-2-{2-[((S)-1-{(S)-...)
Affinity DataIC50:  8.90nMAssay Description:In vitro inhibition of the human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate Suc-Ala-Pro-Ala-MCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109763(4-Carboxymethoxy-benzoic acid (1-{2-[1-(benzooxazo...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of the human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate Suc-Ala-Pro-Ala-MCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067407((3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[p...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)
Affinity DataIC50:  21nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067390(2'-(3,4-dichlorobenzyl)spiro[tetrahydro-1H-pyrrole...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109756((4-{[(1-{2-[1-(Benzooxazole-2-carbonyl)-2-methyl-p...)
Affinity DataIC50:  33nMAssay Description:In vitro inhibition of the human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate Suc-Ala-Pro-Ala-MCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067379(2'-(3-chlorobenzyl)spiro[tetrahydro-1H-pyrrole-3,4...)
Affinity DataIC50:  35nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067401(2'-(4-bromo-2-fluorobenzyl)-6'-chlorospiro[tetrahy...)
Affinity DataIC50:  35nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067391(2'-(2-chlorobenzyl)spiro[tetrahydro-1H-pyrrole-3,4...)
Affinity DataIC50:  37nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067409(2'-(3-bromobenzyl)spiro[tetrahydro-1H-pyrrole-3,4'...)
Affinity DataIC50:  37nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067396(2'-(4-chlorobenzyl)spiro[tetrahydro-1H-pyrrole-3,4...)
Affinity DataIC50:  38nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067400(6'-bromo-2'-(4-bromo-2-fluorobenzyl)spiro[tetrahyd...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067375(2'-(4-chloro-2-fluorobenzyl)spiro[tetrahydro-1H-py...)
Affinity DataIC50:  41nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067376(2'-(4-bromo-2-fluorobenzyl)spiro[tetrahydro-1H-pyr...)
Affinity DataIC50:  45nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067382(2'-(4-methoxybenzyl)spiro[tetrahydro-1H-pyrrole-3,...)
Affinity DataIC50:  46nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067399(2'-(4-bromobenzyl)spiro[tetrahydro-1H-pyrrole-3,4'...)
Affinity DataIC50:  47nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067402(2'-(4-bromo-2-fluorobenzyl)-7'-chlorospiro[tetrahy...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067395(6',7'-dibromo-2'-(4-bromo-2-fluorobenzyl)spiro[tet...)
Affinity DataIC50:  52nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067386(2'-(4-methylbenzyl)spiro[tetrahydro-1H-pyrrole-3,4...)
Affinity DataIC50:  52nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067413(2'-(2-bromobenzyl)spiro[tetrahydro-1H-pyrrole-3,4'...)
Affinity DataIC50:  52nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067411(2'-(2-fluorobenzyl)spiro[tetrahydro-1H-pyrrole-3,4...)
Affinity DataIC50:  61nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109759(CHEMBL358686 | N-(1-{2-[1-(Benzooxazole-2-carbonyl...)
Affinity DataIC50:  66nMAssay Description:In vitro inhibition of the human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate Suc-Ala-Pro-Ala-MCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109775(3-(1-{2-[1-(Benzooxazole-2-carbonyl)-2-methyl-prop...)
Affinity DataIC50:  72nMAssay Description:In vitro inhibition of the human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate Suc-Ala-Pro-Ala-MCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067387(2'-(2,4-difluorobenzyl)spiro[tetrahydro-1H-pyrrole...)
Affinity DataIC50:  72nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067414(2'-(4-trifluoromethylbenzyl)spiro[tetrahydro-1H-py...)
Affinity DataIC50:  80nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067394(2'-benzylspiro[tetrahydro-1H-pyrrole-3,4'-(1',2',3...)
Affinity DataIC50:  99nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067388(7'-bromo-2'-(4-bromo-2-fluorobenzyl)spiro[tetrahyd...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067380(2'-(4-nitrobenzyl)spiro[tetrahydro-1H-pyrrole-3,4'...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067381(2'-(3,4-dimethoxybenzyl)spiro[tetrahydro-1H-pyrrol...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067404(2'-(4-fluorobenzyl)spiro[tetrahydro-1H-pyrrole-3,4...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109758(2,2-Dimethyl-propionic acid 2-{2-[2-(4-carboxymeth...)
Affinity DataIC50:  130nMAssay Description:In vitro inhibition of the human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate Suc-Ala-Pro-Ala-MCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067398(CHEMBL133662 | [2-(3,4-Dichloro-benzyl)-1,3-dioxo-...)
Affinity DataIC50:  131nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067405(3-[2-(3,4-Dichloro-benzyl)-1,3-dioxo-1,2,3,4-tetra...)
Affinity DataIC50:  132nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067403(2'-(4-aminobenzyl)spiro[tetrahydro-1H-pyrrole-3,4'...)
Affinity DataIC50:  140nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067392(CHEMBL134089 | [2-(4-Bromo-2-fluoro-benzyl)-1,3-di...)
Affinity DataIC50:  165nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067397((3S)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[p...)
Affinity DataIC50:  190nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067416(2'-phenylspiro[tetrahydro-1H-pyrrole-3,4'-(1',2',3...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067408(7'-acetyl-2'-(4-bromo-2-fluorobenzyl)spiro[tetrahy...)
Affinity DataIC50:  210nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109769(2,2-Dimethyl-propionic acid 2-[2-({1-[2-(4-carboxy...)
Affinity DataIC50:  230nMAssay Description:In vitro inhibition of the human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate Suc-Ala-Pro-Ala-MCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067385(2'-phenethylspiro[tetrahydro-1H-pyrrole-3,4'-(1',2...)
Affinity DataIC50:  270nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109755(2-[3-(1-{2-[1-(Benzooxazole-2-carbonyl)-2-methyl-p...)
Affinity DataIC50:  280nMAssay Description:In vitro inhibition of the human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate Suc-Ala-Pro-Ala-MCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067406(2'-methylspiro[tetrahydro-1H-pyrrole-3,4'-(1',2',3...)
Affinity DataIC50:  280nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109768(CHEMBL152728 | {4-[2-(2-{2-Methyl-1-[4-(3-methyl-b...)
Affinity DataIC50:  290nMAssay Description:In vitro inhibition of the human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate Suc-Ala-Pro-Ala-MCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067377(2'-(2,4-dimethoxybenzyl)spiro[tetrahydro-1H-pyrrol...)
Affinity DataIC50:  350nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50109772(2,2-Dimethyl-propionic acid 2-(2-benzyloxycarbonyl...)
Affinity DataIC50:  450nMAssay Description:In vitro inhibition of the human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate Suc-Ala-Pro-Ala-MCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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