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Found 177 with Last Name = 'koyano' and Initial = 'h'
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of recombinant c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402202(CHEMBL2203964)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402204(CHEMBL2203978)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306677((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306677((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  23nMAssay Description:Inhibition of recombinant c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306680(CHEMBL598912 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402206(CHEMBL2203976)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306679(CHEMBL608738 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...)
Affinity DataIC50:  59nMAssay Description:Inhibition of recombinant c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306685(CHEMBL602470 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...)
Affinity DataIC50:  94nMAssay Description:Inhibition of recombinant c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306683((R)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306678(CHEMBL591457 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...)
Affinity DataIC50:  205nMAssay Description:Inhibition of recombinant c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  230nMAssay Description:Inhibition of recombinant RON by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402207(CHEMBL2203975)
Affinity DataIC50:  250nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402203(CHEMBL2203963)
Affinity DataIC50:  260nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402208(CHEMBL2203974)
Affinity DataIC50:  280nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402200(CHEMBL2203966)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402201(CHEMBL2203965)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306686(CHEMBL599993 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...)
Affinity DataIC50:  368nMAssay Description:Inhibition of recombinant c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  430nMAssay Description:Inhibition of recombinant AXL by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306677((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  450nMAssay Description:Inhibition of recombinant RON by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306681((S)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Affinity DataIC50:  453nMAssay Description:Inhibition of recombinant c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402205(CHEMBL2203977)
Affinity DataIC50:  480nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402199(CHEMBL2203967)
Affinity DataIC50:  510nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306677((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  570nMAssay Description:Inhibition of recombinant AXL by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402215(CHEMBL1624076)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306681((S)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of recombinant c-Met by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50241121((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402214(CHEMBL2203968)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306683((R)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of recombinant RON by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306677((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of recombinant EphA2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of recombinant EphA2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306677((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of recombinant Aurora A by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306677((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of recombinant FGFR2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402212(CHEMBL2203970)
Affinity DataIC50:  8.13E+3nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402213(CHEMBL2203969)
Affinity DataIC50:  8.28E+3nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402211(CHEMBL2203971)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402210(CHEMBL2203972)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukocyte tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of recombinant LTK by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402209(CHEMBL2203973)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306677((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of recombinant Abl by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant KDR by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306677((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of recombinant KDR by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of recombinant FGFR2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306683((R)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of recombinant AXL by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306677((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of recombinant LCK by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of recombinant Flt3 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukocyte tyrosine kinase receptor(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306677((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of recombinant LTK by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306681((S)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of recombinant Src by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50306684(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of recombinant Aurora A by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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