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Found 6597 with Last Name = 'kreutter' and Initial = 'k'
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50123504(CHEMBL142546 | N-((6-amino-2-methylpyridin-3-yl)me...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377618(CHEMBL254353)
Affinity DataKi:  0.380nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377625(CHEMBL254557)
Affinity DataKi:  0.570nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377615(CHEMBL254962)
Affinity DataKi:  0.650nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377623(CHEMBL254759)
Affinity DataKi:  0.660nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50223074(CHEMBL250466 | N-((6-amino-2-methylpyridin-3-yl)me...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human thrombin after 15 mins by standard chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377611(CHEMBL258018)
Affinity DataKi:  0.770nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377619(CHEMBL402758)
Affinity DataKi:  0.790nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50223067(CHEMBL250651 | N-(6-amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human thrombin after 15 mins by standard chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377622(CHEMBL257543)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377620(CHEMBL254784)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377614(CHEMBL401655)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377617(CHEMBL403359)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377624(CHEMBL403310)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50223066(CHEMBL250650 | N-[2-({[amino(imino)methyl]amino}ox...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human thrombin after 15 mins by standard chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377607(CHEMBL404025)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50223081(CHEMBL250273 | N-[2-(carbamimidamidooxy)ethyl]-2-(...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of human thrombin after 15 mins by standard chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50223071(CHEMBL399868 | N-((6-amino-2-methylpyridin-3-yl)me...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of human thrombin after 15 mins by standard chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377626(CHEMBL254786)
Affinity DataKi:  2.90nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50223069(CHEMBL250461 | N-[2-(carbamimidamidooxy)ethyl]-2-(...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of human thrombin after 15 mins by standard chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377616(CHEMBL258198)
Affinity DataKi:  3.20nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50223078(CHEMBL250465 | N-((6-amino-2,4-dimethylpyridin-3-y...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of human thrombin after 15 mins by standard chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377608(CHEMBL256941)
Affinity DataKi:  4nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50149023(3-{[1-({[(diaminomethylidene)amino]oxy}methyl)cycl...)
Affinity DataKi:  4nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50149023(3-{[1-({[(diaminomethylidene)amino]oxy}methyl)cycl...)
Affinity DataKi:  4nMAssay Description:Binding affinity to thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50223065(CHEMBL250460 | N-[2-(carbamimidamidooxy)ethyl]-2-(...)
Affinity DataKi:  4.70nMAssay Description:Inhibition of human thrombin after 15 mins by standard chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50223075(CHEMBL250463 | N-[2-({[amino(imino)methyl]amino}ox...)
Affinity DataKi:  8.60nMAssay Description:Inhibition of human thrombin after 15 mins by standard chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377613(CHEMBL258225)
Affinity DataKi:  9nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM471715((R)-N-(1-Acryloylpiperidin-3-yl)-5-(2-fluoro-4-phe...)
Affinity DataKi:  9.20nMAssay Description:Covalent inhibition of recombinant human GST-tagged BTK (2 to 659 end residues) expressed in baculovirus expression system assessed as inhibition con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50223076(CHEMBL399662 | N-((6-amino-2-methylpyridin-3-yl)me...)
Affinity DataKi:  10nMAssay Description:Inhibition of human thrombin after 15 mins by standard chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377621(CHEMBL254785)
Affinity DataKi:  10nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377612(CHEMBL255916)
Affinity DataKi:  11nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50569791(CHEMBL4846828)
Affinity DataKi:  12nMAssay Description:Covalent inhibition of recombinant human GST-tagged BTK (2 to 659 end residues) expressed in baculovirus expression system assessed as inhibition con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467364((R)-N-(1-Acryloylpiperidin-3-yl)-5-(2-chloro-4-phe...)
Affinity DataKi:  12nMAssay Description:Covalent inhibition of recombinant human GST-tagged BTK (2 to 659 end residues) expressed in baculovirus expression system assessed as inhibition con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM123630(US8748624, 144)
Affinity DataKi:  12.4nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucagon receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM123549(US8748624, 35)
Affinity DataKi:  14.4nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucagon receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM123582(US8748624, 74)
Affinity DataKi:  14.9nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM485273(N-((1R,2S)-2-Acrylamidocyclopentyl)-5-(*S)-(2-meth...)
Affinity DataKi:  15nMAssay Description:Covalent inhibition of recombinant human GST-tagged BTK (2 to 659 end residues) expressed in baculovirus expression system assessed as inhibition con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM123633(US8748624, 147)
Affinity DataKi:  15.7nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucagon receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM123556(US8748624, 42)
Affinity DataKi:  16.5nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucagon receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM123637(US8748624, 151)
Affinity DataKi:  16.5nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucagon receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM123559(US8748624, 51)
Affinity DataKi:  16.8nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucagon receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM123557(US8748624, 43)
Affinity DataKi:  17.2nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucagon receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM123651(US8748624, 174)
Affinity DataKi:  18.3nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucagon receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM123558(US8748624, 44)
Affinity DataKi:  18.4nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucagon receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM123634(US8748624, 148)
Affinity DataKi:  18.7nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucagon receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM123575(US8748624, 67)
Affinity DataKi:  18.8nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50377609(CHEMBL256091)
Affinity DataKi:  19nMAssay Description:Binding affinity to human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM123544(US8748624, 30)
Affinity DataKi:  19.3nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucagon receptor(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM123535(US8748624, 21)
Affinity DataKi:  19.4nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
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