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Found 333 with Last Name = 'kufareva' and Initial = 'i'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50063266(6-Nitro-2-piperazin-1-yl-quinoline | 6-nitroquipaz...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]-5HT from human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Troms£

LigandPNGBDBM105212(2-(4-Nonyl-piperazin-1-yl)-6-nitroquinoline (9))
Affinity DataKi:  1.80nM ΔG°:  -49.9kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563426(CHEMBL4783861)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Troms£

LigandPNGBDBM105213(2-(4-Decyl-piperazin-1-yl)-6-nitroquinoline (10))
Affinity DataKi:  4.5nM ΔG°:  -47.6kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563422(CHEMBL4760108)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM25876(4,4-dimethyl-1-{4-[4-(quinolin-2-yl)piperazin-1-yl...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Troms£

LigandPNGBDBM105214(2-(4-Undecyl-piperazin-1-yl)-6-nitroquinoline (11))
Affinity DataKi:  12.6nM ΔG°:  -45.1kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM25869(2-{4-[2-methyl-4-(quinolin-2-yl)piperazin-1-yl]but...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50363815(CHEMBL1945686)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Troms£

LigandPNGBDBM105215(2-(4-Dodecyl-piperazin-1-yl)-6-nitroquinoline (12))
Affinity DataKi:  16.1nM ΔG°:  -44.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563424(CHEMBL4793148)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Troms£

LigandPNGBDBM105211(2-(4-Octyl-piperazin-1-yl)-6-nitroquinoline (8))
Affinity DataKi:  20.8nM ΔG°:  -43.8kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563424(CHEMBL4793148)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM25873(8-{4-[2-methyl-4-(quinolin-2-yl)piperazin-1-yl]but...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Troms£

LigandPNGBDBM105207(2-(4-Butyl-piperazin-1-yl)-6-nitroquinoline (4))
Affinity DataKi:  24nM ΔG°:  -43.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-5HT from human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563423(CHEMBL4791522)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563423(CHEMBL4791522)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50306766(CHEMBL604535 | N2-(5-chloro-2-methoxyphenyl)-6-(3-...)
Affinity DataKi:  32nMAssay Description:Inhibition of human adenosine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM25871(1-{4-[2-methyl-4-(quinolin-2-yl)piperazin-1-yl]but...)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM25874(2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}-2,3-d...)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM25875(8-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}-8-aza...)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Troms£

LigandPNGBDBM105210(2-(4-Heptyl-piperazin-1-yl)-6-nitroquinoline (7))
Affinity DataKi:  54.1nM ΔG°:  -41.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50306768(2-amino-4-phenylbenzofuro[3,2-b]pyridine-3-carboni...)
Affinity DataKi:  60nMAssay Description:Inhibition of human adenosine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563425(CHEMBL4795646)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research

Curated by ChEMBL
LigandPNGBDBM50563425(CHEMBL4795646)
Affinity DataKi:  63.1nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 5(Homo sapiens (Human))
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM54115(5-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro...)
Affinity DataKi:  65.3nMAssay Description:Inhibition of ABCC5 in human erythrocytes assessed as inhibition of ATP-mediated [3H]cGMP uptake in inside-out vesicles after 60 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Troms£

LigandPNGBDBM105209(2-(4-Hexyl-piperazin-1-yl)-6-nitroquinoline (6))
Affinity DataKi:  72.9nM ΔG°:  -40.7kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 5(Homo sapiens (Human))
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50386476(CHEMBL2047880)
Affinity DataKi:  75.3nMAssay Description:Inhibition of ABCC5 in human erythrocytes assessed as inhibition of ATP-mediated [3H]cGMP uptake in inside-out vesicles after 60 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Troms£

LigandPNGBDBM105208(2-(4-Pentyl-piperazin-1-yl)-6-nitroquinoline (5))
Affinity DataKi:  80.5nM ΔG°:  -40.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Troms£

LigandPNGBDBM105205(2-(4-Ethyl-piperazin-1-yl)-6-nitroquinoline (2))
Affinity DataKi:  86.1nM ΔG°:  -40.3kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataKi:  180nMAssay Description:Competitive inhibition of recombinant human GST-tagged CK2alpha by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataKi:  180nMAssay Description:Competitive inhibition of recombinant human GST-tagged CK2alpha by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50363810(CHEMBL1945681)
Affinity DataKi:  221nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Affinity DataKi:  230nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50306769(1-amino-4-chloroanthracene-9,10-dione | CHEMBL6030...)
Affinity DataKi:  250nMAssay Description:Inhibition of human adenosine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM25872(2-{3-[2-methyl-4-(quinolin-2-yl)piperazin-1-yl]pro...)
Affinity DataKi:  275nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50306776(3-amino-N-(2-fluorophenyl)-5-oxo-5,6,7,8-tetrahydr...)
Affinity DataKi:  300nMAssay Description:Inhibition of human adenosine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50094895(1,4-diamino-9,10-anthraquinone | 1,4-diamino-anthr...)
Affinity DataKi:  320nMAssay Description:Inhibition of human adenosine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Troms£

LigandPNGBDBM105206(2-(4-Propyl-piperazin-1-yl)-6-nitroquinoline (3))
Affinity DataKi:  496nM ΔG°:  -36.0kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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