TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Medicines Institute
Curated by ChEMBL
National Medicines Institute
Curated by ChEMBL
Affinity DataKi: 0.170nMAssay Description:Displacement of [3H]-5HT from human SERTMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 0.631nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 0.631nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Affinity DataKi: 1.80nM ΔG°: -49.9kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 4.40nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Affinity DataKi: 4.5nM ΔG°: -47.6kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 6.10nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 6.30nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 6.30nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute
Curated by ChEMBL
National Medicines Institute
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
Affinity DataKi: 12.6nM ΔG°: -45.1kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute
Curated by ChEMBL
National Medicines Institute
Curated by ChEMBL
Affinity DataKi: 13nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute
Curated by ChEMBL
National Medicines Institute
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
Affinity DataKi: 16.1nM ΔG°: -44.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 20.8nM ΔG°: -43.8kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 22nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute
Curated by ChEMBL
National Medicines Institute
Curated by ChEMBL
Affinity DataKi: 24nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
Affinity DataKi: 24nM ΔG°: -43.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Medicines Institute
Curated by ChEMBL
National Medicines Institute
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Displacement of [3H]-5HT from human SERTMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 31nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 32nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Inhibition of human adenosine 2A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute
Curated by ChEMBL
National Medicines Institute
Curated by ChEMBL
Affinity DataKi: 37nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute
Curated by ChEMBL
National Medicines Institute
Curated by ChEMBL
Affinity DataKi: 39nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute
Curated by ChEMBL
National Medicines Institute
Curated by ChEMBL
Affinity DataKi: 39nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
Affinity DataKi: 54.1nM ΔG°: -41.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:Inhibition of human adenosine 2A receptorMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 63nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 63.1nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 5(Homo sapiens (Human))
University Of Troms£
Curated by ChEMBL
University Of Troms£
Curated by ChEMBL
Affinity DataKi: 65.3nMAssay Description:Inhibition of ABCC5 in human erythrocytes assessed as inhibition of ATP-mediated [3H]cGMP uptake in inside-out vesicles after 60 mins by liquid scint...More data for this Ligand-Target Pair
Affinity DataKi: 72.9nM ΔG°: -40.7kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 5(Homo sapiens (Human))
University Of Troms£
Curated by ChEMBL
University Of Troms£
Curated by ChEMBL
Affinity DataKi: 75.3nMAssay Description:Inhibition of ABCC5 in human erythrocytes assessed as inhibition of ATP-mediated [3H]cGMP uptake in inside-out vesicles after 60 mins by liquid scint...More data for this Ligand-Target Pair
Affinity DataKi: 80.5nM ΔG°: -40.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
Affinity DataKi: 86.1nM ΔG°: -40.3kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
Affinity DataKi: 180nMAssay Description:Competitive inhibition of recombinant human GST-tagged CK2alpha by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 180nMAssay Description:Competitive inhibition of recombinant human GST-tagged CK2alpha by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute
Curated by ChEMBL
National Medicines Institute
Curated by ChEMBL
Affinity DataKi: 221nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute
Curated by ChEMBL
National Medicines Institute
Curated by ChEMBL
Affinity DataKi: 230nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human adenosine 2A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute
Curated by ChEMBL
National Medicines Institute
Curated by ChEMBL
Affinity DataKi: 275nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of human adenosine 2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 320nMAssay Description:Inhibition of human adenosine 2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 496nM ΔG°: -36.0kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair