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Found 261 with Last Name = 'kuhn' and Initial = 'c'
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50385150(CHEMBL2035650)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of HPGDSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM84796(PF-00215924)
Affinity DataIC50:  1.80nMpH: 7.5 T: 2°CAssay Description:Inhibition of active p38a MAP kinase by inhibitors was determinedusing a p38a cascade activity assay. A 30-lL reaction mixture wasprepared containing...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50385142(CHEMBL2035651)
Affinity DataIC50:  2.34nMAssay Description:Inhibition of human recombinant HPGDS using PGH2 as substrate assessed as production of PGD2 preincubated for 10 mins prior substrate addition measur...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM26514(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323438(4-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureido)-1H-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM84788((9a) BIRB796)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:Binding of inhibitors to unactivated p38a that leads to decreasedphosphorylation of p38alpha by MKK6 was determined by measuringthe activated p38alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323438(4-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureido)-1H-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323416(2-acetamido-N-(3-(3-tert-butyl-5-(3-phenylureido)-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM26514(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  6.70nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM84786((10a) BIRB796)
Affinity DataIC50:  7nMpH: 7.5 T: 2°CAssay Description:Binding of inhibitors to unactivated p38a that leads to decreasedphosphorylation of p38alpha by MKK6 was determined by measuringthe activated p38alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM84782((5a) BIRB796)
Affinity DataIC50:  8nMpH: 7.5 T: 2°CAssay Description:Binding of inhibitors to unactivated p38a that leads to decreasedphosphorylation of p38alpha by MKK6 was determined by measuringthe activated p38alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  8nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50385144(CHEMBL2035653)
Affinity DataIC50:  8.26nMAssay Description:Inhibition of human recombinant HPGDS using PGH2 as substrate assessed as production of PGD2 preincubated for 10 mins prior substrate addition measur...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM84791((11a) BIRB796)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:Binding of inhibitors to unactivated p38a that leads to decreasedphosphorylation of p38alpha by MKK6 was determined by measuringthe activated p38alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM84784((6a) BIRB796 | (8a) BIRB796)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:Binding of inhibitors to unactivated p38a that leads to decreasedphosphorylation of p38alpha by MKK6 was determined by measuringthe activated p38alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM84785((7a) BIRB796)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:Binding of inhibitors to unactivated p38a that leads to decreasedphosphorylation of p38alpha by MKK6 was determined by measuringthe activated p38alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM26514(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  11.5nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  13.6nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323437((1R)-6-(3-(3-tert-butyl-5-(3-phenylureido)-1H-pyra...)
Affinity DataIC50:  14nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323427(CHEMBL1209482 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  16nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50:  16.8nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323420(CHEMBL1209343 | N-(2-(3-(3-tert-butyl-5-(3-phenylu...)
Affinity DataIC50:  18nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50005004(CHEMBL2397309)
Affinity DataIC50:  22nMAssay Description:Inhibition of PI4K3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM84789((9b) BIRB796)
Affinity DataIC50:  22nMpH: 7.5 T: 2°CAssay Description:Binding of inhibitors to unactivated p38a that leads to decreasedphosphorylation of p38alpha by MKK6 was determined by measuringthe activated p38alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM84784((6a) BIRB796 | (8a) BIRB796)
Affinity DataIC50:  25nMpH: 7.5 T: 2°CAssay Description:Binding of inhibitors to unactivated p38a that leads to decreasedphosphorylation of p38alpha by MKK6 was determined by measuringthe activated p38alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM84783((5b) BIRB796)
Affinity DataIC50:  26nMpH: 7.5 T: 2°CAssay Description:Binding of inhibitors to unactivated p38a that leads to decreasedphosphorylation of p38alpha by MKK6 was determined by measuringthe activated p38alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323431(CHEMBL1209564 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  27.9nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323435((1R)-2-(3-(3-tert-butyl-5-(3-phenylureido)-1H-pyra...)
Affinity DataIC50:  30nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50175297(CHEMBL3810245)
Affinity DataIC50:  31nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323416(2-acetamido-N-(3-(3-tert-butyl-5-(3-phenylureido)-...)
Affinity DataIC50:  34nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333483(1-[5-tert-Butyl-3-(1,1-dioxo-1lambda*6*-thiomorpho...)
Affinity DataIC50:  34nMAssay Description:Inhibition of S6K1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50005008(CHEMBL2397312)
Affinity DataIC50:  35nMAssay Description:Inhibition of PI4K3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM84792((11b) BIRB796)
Affinity DataIC50:  35nMpH: 7.5 T: 2°CAssay Description:Binding of inhibitors to unactivated p38a that leads to decreasedphosphorylation of p38alpha by MKK6 was determined by measuringthe activated p38alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM84790((7b) BIRB796)
Affinity DataIC50:  36nMpH: 7.5 T: 2°CAssay Description:Binding of inhibitors to unactivated p38a that leads to decreasedphosphorylation of p38alpha by MKK6 was determined by measuringthe activated p38alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323433(4-(3-(3-tert-butyl-5-(3-phenylureido)-1H-pyrazol-1...)
Affinity DataIC50:  37nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323419(CHEMBL1209342 | N-(2-(3-(3-tert-butyl-5-(3-phenylu...)
Affinity DataIC50:  38nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323434(4-(3-(3-tert-butyl-5-(3-phenylureido)-1H-pyrazol-1...)
Affinity DataIC50:  39nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50005009(CHEMBL2397311)
Affinity DataIC50:  40nMAssay Description:Inhibition of PI4K3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50436476(CHEMBL2397316)
Affinity DataIC50:  48nMAssay Description:Inhibition of PI4K3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323430(CHEMBL1209563 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  48.8nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323418(CHEMBL1209276 | N-(2-(3-(3-tert-butyl-5-(3-phenylu...)
Affinity DataIC50:  51nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50436477(CHEMBL2397315)
Affinity DataIC50:  53nMAssay Description:Inhibition of PI4K3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50005007(CHEMBL2397310)
Affinity DataIC50:  53nMAssay Description:Inhibition of PI4K3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM84794((12a) BIRB796)
Affinity DataIC50:  53nMpH: 7.5 T: 2°CAssay Description:Binding of inhibitors to unactivated p38a that leads to decreasedphosphorylation of p38alpha by MKK6 was determined by measuringthe activated p38alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323436((1R)-2-(3-(3-tert-butyl-5-(3-phenylureido)-1H-pyra...)
Affinity DataIC50:  57nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50374929(CHEMBL402364)
Affinity DataIC50:  60nMAssay Description:Inhibition of human integrin alpha-4-beta-7-MAdCAM interaction in human RPMI 8866 cells by whole-cell adhesion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM84793((12b) BIRB796)
Affinity DataIC50:  62nMpH: 7.5 T: 2°CAssay Description:Binding of inhibitors to unactivated p38a that leads to decreasedphosphorylation of p38alpha by MKK6 was determined by measuringthe activated p38alph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323427(CHEMBL1209482 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  63nMAssay Description:Inhibition of active p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50005010(CHEMBL2397313)
Affinity DataIC50:  67nMAssay Description:Inhibition of PI4K3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50323415(CHEMBL1209273 | N-(3-(3-tert-butyl-5-(3-phenylurei...)
Affinity DataIC50:  68nMAssay Description:Inhibition of unactive p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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