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Found 284 with Last Name = 'kurihara' and Initial = 'h'
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataKi:  38nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50096004(7-Hydroxy-3-[4-(2-oxo-2H-chromen-3-yl)-thiazol-2-y...)
Affinity DataKi:  280nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50096003(7-Hydroxy-3-phenyl-chromen-2-one | 7-hydroxy-3-phe...)
Affinity DataKi:  470nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50096001(7-Hydroxy-3-pyrazolo[1,5-a]pyridin-2-yl-chromen-2-...)
Affinity DataKi:  500nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50095993(7-Hydroxy-2-oxo-2H-chromene-3-carbothioic acid ami...)
Affinity DataKi:  550nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50096002(3-(4-Benzo[1,3]dioxol-5-yl-thiazol-2-yl)-7-hydroxy...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50096007(2-Oxo-2H-chromene-3-carboxylic acid 2-oxo-2-phenyl...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50096006(7-Hydroxy-3-(2-methyl-thiazol-4-yl)-chromen-2-one ...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50096000(3-(2-Fluoro-4-hydroxy-phenyl)-acrylic acid anion)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366376(CHEMBL1159523)
Affinity DataKi:  2.90E+3nMAssay Description:Tested for inhibitory constant against yeast alpha-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50095994(3-Cyano-7-hydroxycoumarin (2) | 7-Hydroxy-2-oxo-2H...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50096005(7-Hydroxy-3-(4-methyl-thiazol-2-yl)-chromen-2-one ...)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50096008(3-Acetyl-7-hydroxy-chromen-2-one | 3-acetyl-7-hydr...)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50095996(3-(7-Hydroxy-2-oxo-2H-chromen-3-yl)-3-oxo-propioni...)
Affinity DataKi:  5.80E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50096009(3-(4-Dimethylamino-benzylidene)-chroman-2,4-dione ...)
Affinity DataKi:  6.20E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yamanouchi Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50095995(7-HYDROXY-2-OXO-CHROMENE-3-CARBOXYLIC ACID ETHYL E...)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50186373(CHEMBL424696 | N-(5-(2-(cyclohexyloxy)pyrimidin-4-...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM1434(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Affinity DataIC50:  2.60nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  4nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  4nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50186373(CHEMBL424696 | N-(5-(2-(cyclohexyloxy)pyrimidin-4-...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5052(5-bromo-N-[(2Z)-4-chloro-3-methyl-5-(propan-2-yl)-...)
Affinity DataIC50:  4.30nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50297965((R)-3-(1-(2-chloro-4-(hydroxymethyl)phenyl)ethoxy)...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  6.90nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  6.90nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50297962((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(imidazo[1,2-a]...)
Affinity DataIC50:  7nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50297966((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(6-(hydroxymeth...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50186375(CHEMBL210540 | N-(5-(2-(cyclohexyloxy)-6-methylpyr...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of CDK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5054(5-Chloro-N-(4-chloro-5-isopropyl-3-methyl-1,3-thia...)
Affinity DataIC50:  9nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50186375(CHEMBL210540 | N-(5-(2-(cyclohexyloxy)-6-methylpyr...)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5051(5-Chloro-N-(4-chloro-5-isopropyl-3-methyl-13-thiaz...)
Affinity DataIC50:  9.40nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5055(N-(4-Chloro-5-isopropyl-3-methyl-1,3-thiazol-2(3H)...)
Affinity DataIC50:  9.5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50297985((R)-3-(1-(4-((tert-butylamino)methyl)-2-(difluorom...)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5041(N-(5-tert-Butyl-3,4-dimethyl-1,3-thiazol-2(3H)-yli...)
Affinity DataIC50:  11nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5048(5-Chloro-2-cyano-N-(5-isopropyl-3,4-dimethyl-1,3-t...)
Affinity DataIC50:  11nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5053(2,5-dicyano-N-[(2Z)-3,4-dimethyl-5-(propan-2-yl)-2...)
Affinity DataIC50:  12nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50297971((R)-3-(1-(2-chloro-4-((cyclopropylamino)methyl)phe...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305863(3-(3-methoxyphenyl)-5-methyl-6-phenylisoxazolo[4,5...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50297981((R)-3-(1-(2-chloro-4-((3-oxopiperazin-1-yl)methyl)...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5052(5-bromo-N-[(2Z)-4-chloro-3-methyl-5-(propan-2-yl)-...)
Affinity DataIC50:  13nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50186374(CHEMBL212049 | N-(5-(2-(cyclohexyloxy)-5-methylpyr...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50297977((R)-3-(1-(2-chloro-4-((4-fluoropiperidin-1-yl)meth...)
Affinity DataIC50:  13nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50186373(CHEMBL424696 | N-(5-(2-(cyclohexyloxy)pyrimidin-4-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50297982(3-{(R)-1-[2-Chloro-4-(1,1-dioxo-1lambda*6*-thiomor...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50297967((R)-3-(1-(2-chloro-4-((methylamino)methyl)phenyl)e...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50297978((R)-3-(1-(2-chloro-4-((4-methylpiperazin-1-yl)meth...)
Affinity DataIC50:  17nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Yamanouchi Pharmaceutical

LigandPNGBDBM5050(5-Bromo-2-cyano-N-(5-isopropyl-3,4-dimethyl-1,3-th...)
Affinity DataIC50:  18nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50297975((R)-3-(1-(2-chloro-4-((3-hydroxypropylamino)methyl...)
Affinity DataIC50:  19nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50186373(CHEMBL424696 | N-(5-(2-(cyclohexyloxy)pyrimidin-4-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50297980(3-((1R)-1-(2-chloro-4-((3-hydroxypyrrolidin-1-yl)m...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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