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Found 166 with Last Name = 'kwan' and Initial = 'jc'
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.173nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.181nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055512(CHEMBL3317812)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055513(CHEMBL3317811)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055514(CHEMBL3317810)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302109(CHEMBL568553 | Grassystatin B)
Affinity DataIC50:  0.354nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055513(CHEMBL3317811)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055515(CHEMBL3317818)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055514(CHEMBL3317810)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  0.886nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055516(CHEMBL3317817)
Affinity DataIC50:  0.960nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055515(CHEMBL3317818)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055515(CHEMBL3317818)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055513(CHEMBL3317811)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055512(CHEMBL3317812)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055512(CHEMBL3317812)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055516(CHEMBL3317817)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055514(CHEMBL3317810)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055516(CHEMBL3317817)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055517(CHEMBL3317816)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055517(CHEMBL3317816)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055518(CHEMBL3317815)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055517(CHEMBL3317816)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  5nMAssay Description:Inhibition of cathepsin D in human MCF7 cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  5nMAssay Description:Inhibition of cathepsin E in human MCF7 cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055510(CHEMBL3317814)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055518(CHEMBL3317815)
Affinity DataIC50:  6nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055518(CHEMBL3317815)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055510(CHEMBL3317814)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50288847(Chymostatin)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of chymase (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  13nMAssay Description:Inhibition of TACE after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055510(CHEMBL3317814)
Affinity DataIC50:  21nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  27nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like elastase family member 1(Sus scrofa (Pig))
Smithsonian Marine Station At Ft. Pierce

Curated by ChEMBL
LigandPNGBDBM50312532(CHEMBL1077010 | molassamide)
Affinity DataIC50:  32nMAssay Description:Inhibition of pig pancreatic elastase preincubated for 15 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055511(CHEMBL3317813)
Affinity DataIC50:  39nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302108(CHEMBL569445 | Grassystatin C)
Affinity DataIC50:  43nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 9(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  56nMAssay Description:Inhibition of ADAM9 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 9(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  56nMAssay Description:Inhibition of ADAM9 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055511(CHEMBL3317813)
Affinity DataIC50:  100nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  102nMAssay Description:Inhibition of HDAC8 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055511(CHEMBL3317813)
Affinity DataIC50:  150nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Smithsonian Marine Station At Ft. Pierce

Curated by ChEMBL
LigandPNGBDBM50312532(CHEMBL1077010 | molassamide)
Affinity DataIC50:  234nMAssay Description:Inhibition of bovine pancreas alpha-chymotrypsin preincubated for 10 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  263nMAssay Description:Inhibition of ADAM10 after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 10(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50288844(CHEMBL4168948)
Affinity DataIC50:  440nMAssay Description:Antagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment pre-incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055515(CHEMBL3317818)
Affinity DataIC50:  540nMAssay Description:Inhibition of HDAC8 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50055516(CHEMBL3317817)
Affinity DataIC50:  790nMAssay Description:Inhibition of HDAC8 (unknown origin) incubated at 37 degC for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50302107(CHEMBL567893 | Grassystatin A)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of cathepsin D in human MCF7 cells by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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