Compile Data Set for Download or QSAR
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Found 83 with Last Name = 'lai' and Initial = 'jy'
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191056((S)-2-amino-3-(4-hydroxy-phenyl)-N-((R)-1-{[((S)-1...)
Affinity DataIC50:  0.970nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191056((S)-2-amino-3-(4-hydroxy-phenyl)-N-((R)-1-{[((S)-1...)
Affinity DataIC50:  0.990nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132450(3-[1-(5-Methoxy-1-methyl-1H-indol-3-yl)-meth-(Z)-y...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132447(5-[5-Methoxy-3-(2-oxo-5-sulfamoyl-1,2-dihydro-indo...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132443(4-{5-Methoxy-3-[2-oxo-5-sulfamoyl-1,2-dihydro-indo...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132436(3-((1-methyl-1H-indol-3-yl)methylene)-2-oxoindolin...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132434(4-{5-Methoxy-3-[2-oxo-5-sulfamoyl-1,2-dihydro-indo...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132433(3-[1-(5-Methoxy-1-methyl-1H-indol-3-yl)-meth-(Z)-y...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132457(3-{5-Methoxy-3-[2-oxo-5-sulfamoyl-1,2-dihydro-indo...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132445(3-[1-(5-Methoxy-1H-indol-3-yl)-meth-(Z)-ylidene]-2...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191053(1-ethyl-3-(3-oxo-3-((1-phenethylpiperidin-4-yl)(ph...)
Affinity DataIC50:  30nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132437(3-((1-(3-hydroxypropyl)-5-methoxy-1H-indol-3-yl)me...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191056((S)-2-amino-3-(4-hydroxy-phenyl)-N-((R)-1-{[((S)-1...)
Affinity DataIC50:  35nMAssay Description:Activity at delta opioid receptor by MVD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191056((S)-2-amino-3-(4-hydroxy-phenyl)-N-((R)-1-{[((S)-1...)
Affinity DataIC50:  42nMAssay Description:Activity at mu opioid receptor by GPI/LMMP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132441(3-(3-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)...)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132448(2-[3-(5-Methoxy-1-methyl-1H-indol-3-ylmethylene)-2...)
Affinity DataIC50:  98nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132456(3-[1-(5-Methoxy-1-methyl-1H-indol-3-yl)-meth-(Z)-y...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132453(3-[1-(1H-Indol-3-yl)-meth-(Z)-ylidene]-2-oxo-2,3-d...)
Affinity DataIC50:  128nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132449(3-((1-(4-morpholino-4-oxobutyl)-1H-indol-3-yl)meth...)
Affinity DataIC50:  133nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132451(3-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)-N-...)
Affinity DataIC50:  145nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191057(CHEMBL214657 | N-(1-phenethylpiperidin-4-yl)-N-phe...)
Affinity DataIC50:  146nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132452(4-{5-Methoxy-3-[2-oxo-5-sulfamoyl-1,2-dihydro-indo...)
Affinity DataIC50:  204nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191055(3-(1,3-dioxoisoindolin-2-yl)-N-(1-phenethylpiperid...)
Affinity DataIC50:  217nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132435(3-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)-2-...)
Affinity DataIC50:  273nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191058(CHEMBL214285 | N-(1-phenethyl-piperidin-4-yl)-N-ph...)
Affinity DataIC50:  450nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191058(CHEMBL214285 | N-(1-phenethyl-piperidin-4-yl)-N-ph...)
Affinity DataIC50:  451nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132454(6-{5-Methoxy-3-[2-oxo-5-sulfamoyl-1,2-dihydro-indo...)
Affinity DataIC50:  465nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132438(2-Oxo-3-[1-[1-(4-oxo-4-piperidin-1-yl-butyl)-1H-in...)
Affinity DataIC50:  616nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132432(2-(3-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)...)
Affinity DataIC50:  658nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132444(5-{5-Methoxy-3-[2-oxo-5-sulfamoyl-1,2-dihydro-indo...)
Affinity DataIC50:  678nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132440(2-(5-methoxy-3-((2-oxo-5-sulfamoylindolin-3-yliden...)
Affinity DataIC50:  850nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132439(3-[1-(5-Methoxy-1-methyl-1H-indol-3-yl)-meth-(Z)-y...)
Affinity DataIC50:  937nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132446(CHEMBL104583 | tert-butyl 2-(5-methoxy-3-((2-oxo-5...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191060(3-acetamido-N-(1-phenethylpiperidin-4-yl)-N-phenyl...)
Affinity DataIC50:  1.03E+3nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191054(3-amino-N-(1-phenethylpiperidin-4-yl)-N-phenylprop...)
Affinity DataIC50:  2.08E+3nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191059(2-acetylamino-N-{2-[(1-phenethyl-piperidin-4-yl)-p...)
Affinity DataIC50:  2.68E+3nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM21114(3-{phenyl[1-(2-phenylethyl)piperidin-4-yl]carbamoy...)
Affinity DataIC50:  5.40E+3nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191053(1-ethyl-3-(3-oxo-3-((1-phenethylpiperidin-4-yl)(ph...)
Affinity DataIC50:  6.65E+3nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191059(2-acetylamino-N-{2-[(1-phenethyl-piperidin-4-yl)-p...)
Affinity DataIC50:  7.60E+3nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132442(3-(5-Methoxy-1-methyl-1H-indol-3-ylmethyl)-2-oxo-2...)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50191060(3-acetamido-N-(1-phenethylpiperidin-4-yl)-N-phenyl...)
Affinity DataIC50:  8.40E+3nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM21114(3-{phenyl[1-(2-phenylethyl)piperidin-4-yl]carbamoy...)
Affinity DataIC50:  9.40E+3nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PI3K beta (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR2 (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDGFR-beta (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IGF-1R (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of B-Raf (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-Raf (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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