Affinity DataKi: 0.0260nMAssay Description:Compound was tested for inhibition of hog kidney reninMore data for this Ligand-Target Pair
Affinity DataKi: 0.0400nMAssay Description:Inhibition of purified human kidney renin, radioimmunoassay using a synthetic tetradecapeptide renin substrate at 10e-9 M concentrationMore data for this Ligand-Target Pair
Affinity DataKi: 0.0525nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0525nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0640nMAssay Description:Compound was tested for inhibition of human kidney reninMore data for this Ligand-Target Pair
Affinity DataKi: 0.0640nMAssay Description:Inhibition of purified human kidney renin, fluorometric assay using a synthetic tetradecapeptide renin substrate at 10e-9 M concentrationMore data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Inhibition of hog kidney renin at 10e-9 M concentrationMore data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.123nMAssay Description:Displacement of 2-((1E,3E,5E)-5-(1-Ethyl-3,3-dimethyl-5-sulfoindolin-2-ylidene)-penta-1,3-dien-1-yl)-1-(6-((6-((6S,7R,7aR,12bS)-9-hydroxy-7-methoxy-3...More data for this Ligand-Target Pair
Affinity DataKi: 0.155nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.155nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.158nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.158nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Homo sapiens (Human))
University Of Nottingham Biodiscovery Institute
Curated by ChEMBL
University Of Nottingham Biodiscovery Institute
Curated by ChEMBL
Affinity DataKi: 0.178nMAssay Description:Displacement of [3H]mepyramine from human H1R expressed in HEK293T cell homogenates incubated for 1 hr by radioligand binding assay based liquid scin...More data for this Ligand-Target Pair
Affinity DataKi: 0.190nMAssay Description:The compound was tested for inhibition of rhesus monkey plasma renin.More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in HEK293 cells preincubated for 1 hr followed by radioligand addition measured after 1 hr by liqu...More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in HEK293 cells preincubated for 1 hr followed by radioligand addition measured after 1 hr by liqu...More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Inhibition of purified human kidney renin, radioimmunoassay using the natural substrate partially pure angiotensinogen at 10e-9 M concentrationMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Binding affinity at recombinant Hsp90alpha incubated for 16 hrs by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Inhibition of purified human kidney renin, radioimmunoassay using a synthetic tetradecapeptide renin substrate at 10e-9 M concentrationMore data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Inhibition of human PC2 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hrMore data for this Ligand-Target Pair
Affinity DataKi: 0.275nMAssay Description:Displacement of 2-((1E,3E,5E)-5-(1-Ethyl-3,3-dimethyl-5-sulfoindolin-2-ylidene)-penta-1,3-dien-1-yl)-1-(6-((6-((6S,7R,7aR,12bS)-9-hydroxy-7-methoxy-3...More data for this Ligand-Target Pair
Affinity DataKi: 0.288nMAssay Description:Displacement of [3H]DPCPX from human A1 adenosine receptor expressed in Flp-In-CHO cells by radioligand competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.324nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.324nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 0.340nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 0.400nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 0.447nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.447nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.468nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.468nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.540nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
Affinity DataKi: 0.708nMAssay Description:Binding affinity to NanoLuc human A1 adenosine receptor expressed in HEK293-A cells in prescence of SLV320 by NanoBRET competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.724nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.724nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.880nMAssay Description:Inhibition of human kidney reninMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [3H]DPCPX from human A1 adenosine receptor expressed in CHO-K1 cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of 2-((1E,3E,5E)-5-(1-Ethyl-3,3-dimethyl-5-sulfoindolin-2-ylidene)-penta-1,3-dien-1-yl)-1-(6-((6-((6S,7R,7aR,12bS)-9-hydroxy-7-methoxy-3...More data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 1.10nMpH: 6.5Assay Description:Competitive inhibition of human recombinant PACE4 expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamst...More data for this Ligand-Target Pair