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Found 347 with Last Name = 'laping' and Initial = 'n'
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50384444(CHEMBL2035510)
Affinity DataKi:  3.16nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50384444(CHEMBL2035510)
Affinity DataKi:  3.16nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50384443(CHEMBL1770317)
Affinity DataKi:  5.01nMAssay Description:Binding affinity to human EP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50384445(CHEMBL2035508)
Affinity DataKi:  6.31nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50384445(CHEMBL2035508)
Affinity DataKi:  7.94nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50384443(CHEMBL1770317)
Affinity DataKi:  10nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50384443(CHEMBL1770317)
Affinity DataKi:  10nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50384446(CHEMBL2035509)
Affinity DataKi:  12.6nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50384446(CHEMBL2035509)
Affinity DataKi:  19.9nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50384442(CHEMBL2035507)
Affinity DataKi:  200nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50384442(CHEMBL2035507)
Affinity DataKi:  316nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50384442(CHEMBL2035507)
Affinity DataKi: >5.01E+3nMAssay Description:Antagonist activity at EP1 receptor in human U2OS cells expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50384443(CHEMBL1770317)
Affinity DataKi: >5.01E+4nMAssay Description:Antagonist activity at EP1 receptor in human U2OS cells expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304973((S)-4-((2-bromobenzyl)(1-(methylsulfonyl)pyrrolidi...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50296010(2-isobutyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50294706(4-((2-chlorobenzyl)(3-methyl-1-(1-methyl-1H-tetraz...)
Affinity DataIC50:  5nMAssay Description:Binding affinity to progesterone receptor ligand binding domain by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304972((S)-2-chloro-4-((2-chlorobenzyl)(1-(methylsulfonyl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304987((S)-4-((2-bromobenzyl)(1-propionylpyrrolidin-3-yl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304978((S)-methyl 3-((3-chloro-4-cyanophenyl)(2-chloroben...)
Affinity DataIC50:  8nMAssay Description:Inhibition of PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50298032((S)-2-chloro-4-((2-chlorobenzyl)(1-(cyanomethyl)py...)
Affinity DataIC50:  8nMAssay Description:Binding affinity to PR by fluorescence polarization based competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50298033((S)-ethyl 2-(3-((3-chloro-4-cyanophenyl)(2-chlorob...)
Affinity DataIC50:  8nMAssay Description:Binding affinity to PR by fluorescence polarization based competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304977((S)-methyl 3-((3-chloro-4-cyanophenyl)(2-methylben...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304976((S)-methyl 3-((3-chloro-4-cyanophenyl)(2-fluoroben...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304975((S)-methyl 3-((3-chloro-4-cyanophenyl)(2-(trifluor...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184871(4-{2-[(4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-pyr...)
Affinity DataIC50:  12nMAssay Description:Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50294696(4-((2-chlorobenzyl)(1-(2-methylthiazol-4-yl)ethyl)...)
Affinity DataIC50:  13nMAssay Description:Binding affinity to progesterone receptor ligand binding domain by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50294702(4-((2-chlorobenzyl)(1-(1-methyl-1H-tetrazol-5-yl)e...)
Affinity DataIC50:  13nMAssay Description:Binding affinity to progesterone receptor ligand binding domain by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50294703(4-((2-chlorobenzyl)(1-(4-methyl-4H-1,2,4-triazol-3...)
Affinity DataIC50:  13nMAssay Description:Binding affinity to progesterone receptor ligand binding domain by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304964((S)-2-chloro-4-((1-(methylsulfonyl)pyrrolidin-3-yl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50296011(2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin...)
Affinity DataIC50:  13nMAssay Description:Inhibition of SGK1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50294705(4-((2-chlorobenzyl)(1-(1-methyl-1H-tetrazol-5-yl)p...)
Affinity DataIC50:  13nMAssay Description:Binding affinity to progesterone receptor ligand binding domain by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50298030((S)-2-chloro-4-((2-chlorobenzyl)(1-(3,3,3-trifluor...)
Affinity DataIC50:  13nMAssay Description:Binding affinity to PR by fluorescence polarization based competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50294715(4-((2-chlorobenzyl)(1-(4-methyl-4H-1,2,4-triazol-3...)
Affinity DataIC50:  13nMAssay Description:Binding affinity to progesterone receptor ligand binding domain by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184879(CHEMBL424676 | dimethyl-{2-[(4-{4-[3-(pyridin-2-yl...)
Affinity DataIC50:  15nMAssay Description:Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304957((S)-2-chloro-4-((2-methylbenzyl)(1-propionylpyrrol...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50298028((S)-2-chloro-4-((1-methylpyrrolidin-3-yl)(2-(trifl...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PRMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304974((S)-2-chloro-4-((2-methylbenzyl)(1-(methylsulfonyl...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PRMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50294707(4-((2-chlorobenzyl)(1-(1-ethyl-1H-tetrazol-5-yl)et...)
Affinity DataIC50:  16nMAssay Description:Binding affinity to progesterone receptor ligand binding domain by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50294710(2-chloro-4-(isobutyl(3-methyl-1-(1-methyl-1H-tetra...)
Affinity DataIC50:  16nMAssay Description:Binding affinity to progesterone receptor ligand binding domain by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50294712((S)-2-chloro-4-((cyclobutylmethyl)(3-methyl-1-(1-m...)
Affinity DataIC50:  16nMAssay Description:Binding affinity to progesterone receptor ligand binding domain by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50298028((S)-2-chloro-4-((1-methylpyrrolidin-3-yl)(2-(trifl...)
Affinity DataIC50:  16nMAssay Description:Binding affinity to PR by fluorescence polarization based competition binding assayMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50294714(4-((2-chlorobenzyl)(1-(4-methyl-4H-1,2,4-triazol-3...)
Affinity DataIC50:  16nMAssay Description:Binding affinity to progesterone receptor ligand binding domain by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184872(4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-y...)
Affinity DataIC50:  18nMAssay Description:Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184887(2-{4-[(2-chloroethyl)oxy]phenyl}-4-[3-(pyridin-2-y...)
Affinity DataIC50:  19nMAssay Description:Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184890(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-2-[4-(1-pyrro...)
Affinity DataIC50:  19nMAssay Description:Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50294699(4-((2-chlorobenzyl)(1-(3-methylisoxazol-5-yl)ethyl...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to progesterone receptor ligand binding domain by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50294700(4-((2-chlorobenzyl)(1-(1-methyl-1H-imidazol-2-yl)e...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to progesterone receptor ligand binding domain by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304980((S)-methyl 3-((3-chloro-4-cyanophenyl)(5-fluoro-2-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304979((S)-methyl 3-((3-chloro-4-cyanophenyl)(2,3-difluor...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50304971((S)-2-chloro-4-((2-fluorobenzyl)(1-(methylsulfonyl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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