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Found 21 with Last Name = 'lapointe' and Initial = 'j'
TargetGlutamate--tRNA ligase(Escherichia coli)
Crefsip

LigandPNGBDBM18122((4S)-4-amino-5-[({[(2R,3S,4R,5R)-5-(6-amino-9H-pur...)
Affinity DataKi:  2.80nM ΔG°:  -50.8kJ/molepH: 7.2 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAspartate--tRNA ligase(Escherichia coli)
Crefsip

LigandPNGBDBM18127(3-amino-4-[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-...)
Affinity DataKi:  15nM ΔG°:  -46.5kJ/molepH: 7.5 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable glutamate--tRNA ligase, mitochondrial(Mus musculus (mouse))
Crefsip

LigandPNGBDBM18122((4S)-4-amino-5-[({[(2R,3S,4R,5R)-5-(6-amino-9H-pur...)
Affinity DataKi:  70nM ΔG°:  -41.5kJ/molepH: 8.0 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAspartate--tRNA ligase(Escherichia coli)
Crefsip

LigandPNGBDBM18126(3-amino-5-({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-y...)
Affinity DataKi:  123nM ΔG°:  -41.0kJ/molepH: 7.5 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine--tRNA ligase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50366674(CHEMBL609187)
Affinity DataKi:  280nMAssay Description:The compound was evaluated for inhibition of Glutaminyl-tRNA synthetase with respect to glutamine.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine--tRNA ligase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50366674(CHEMBL609187)
Affinity DataKi:  860nMAssay Description:The compound was evaluated for inhibition of Glutaminyl-tRNA synthetase for Escherichia coli with respect to ATP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine--tRNA ligase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50366675(CHEMBL609496)
Affinity DataKi:  1.30E+3nMAssay Description:The compound was evaluated for binding affinity to Glutaminyl-tRNA synthetase with respect to glutamine.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine--tRNA ligase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50366673(CHEMBL608302)
Affinity DataKi:  3.00E+3nMAssay Description:The compound was evaluated for inhibition of Glutaminyl-tRNA synthetase with respect to glutamine.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate--tRNA ligase(Escherichia coli)
Crefsip

LigandPNGBDBM18123((5S)-5-{[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl...)
Affinity DataKi:  1.50E+4nM ΔG°:  -28.6kJ/molepH: 7.2 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate--tRNA ligase(Escherichia coli)
Crefsip

LigandPNGBDBM18118((4S)-4-amino-6-({[(2R,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataKi:  1.80E+4nM ΔG°:  -28.2kJ/molepH: 7.2 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine--tRNA ligase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50290175(4-ammonio-5-{[(2R,4S,6S)-4-hydroxy-6-(hydroxymethy...)
Affinity DataKi:  2.00E+4nMAssay Description:Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM20461((6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methy...)
Affinity DataKi:  4.20E+4nMAssay Description:Compound was tested for the inhibition of aminoacyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAspartate--tRNA ligase(Escherichia coli)
Crefsip

LigandPNGBDBM18124((3S)-3-amino-4-[({[(2R,3S,4R,5R)-5-(6-amino-9H-pur...)
Affinity DataKi:  4.50E+4nM ΔG°:  -25.8kJ/molepH: 7.5 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine--tRNA ligase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50290174(4-ammonio-5-{[(2R,6S)-6-(hydroxymethyl)piperidin-2...)
Affinity DataKi:  2.30E+5nMAssay Description:Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlutamine--tRNA ligase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50403640(CHEMBL2115178)
Affinity DataKi:  3.80E+5nMAssay Description:Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlutamine--tRNA ligase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50366478(CHEMBL609498)
Affinity DataKi:  5.00E+5nMAssay Description:Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlutamine--tRNA ligase(Escherichia coli)
Crefsip

LigandPNGBDBM18120(Gln-KPA | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)...)
Affinity DataKi:  6.50E+5nM ΔG°:  -18.9kJ/molepH: 7.2 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine--tRNA ligase(Bos taurus (bovine))
Crefsip

LigandPNGBDBM18118((4S)-4-amino-6-({[(2R,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataKi:  2.60E+6nM ΔG°:  -15.3kJ/molepH: 7.2 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine--tRNA ligase(Escherichia coli)
Crefsip

LigandPNGBDBM18118((4S)-4-amino-6-({[(2R,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataKi:  2.80E+6nM ΔG°:  -15.2kJ/molepH: 7.2 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate--tRNA ligase(Escherichia coli)
Crefsip

LigandPNGBDBM18120(Gln-KPA | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)...)
Affinity DataKi:  2.90E+6nM ΔG°:  -15.1kJ/molepH: 7.2 T: 2°CAssay Description:The Km and Kappm for the amino acid substrate were first calculated from Lineweaver-Burk plots. The Ki values were calculated from the Kappm vs [I] p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine--tRNA ligase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50403639(CHEMBL2114154)
Affinity DataKi:  1.14E+7nMAssay Description:Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article