TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKi: 0.0300nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKi: 0.110nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
Affinity DataKi: 3.16nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
Affinity DataKi: 3.16nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
Affinity DataKi: 5.01nMAssay Description:Binding affinity to human EP3More data for this Ligand-Target Pair
Affinity DataKi: 6.31nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
Affinity DataKi: 7.94nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
Affinity DataKi: 12.6nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
Affinity DataKi: 19.9nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKi: 41nMAssay Description:The compound was tested for inhibition of Lipoprotein-associated phospholipase A2 (Lp-PLA2)More data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...More data for this Ligand-Target Pair
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research
Curated by ChEMBL
Smith Kline & French Research
Curated by ChEMBL
Affinity DataKi: 290nMAssay Description:Binding affinity of compound towards H+/K+ ATPase for activation was determinedMore data for this Ligand-Target Pair
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research
Curated by ChEMBL
Smith Kline & French Research
Curated by ChEMBL
Affinity DataKi: 290nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
Affinity DataKi: 316nMAssay Description:Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...More data for this Ligand-Target Pair
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research
Curated by ChEMBL
Smith Kline & French Research
Curated by ChEMBL
Affinity DataKi: 838nMAssay Description:Compound was evaluated for its ability to inhibit K+-stimulated ATPase activityMore data for this Ligand-Target Pair
Affinity DataKi: >5.01E+3nMAssay Description:Antagonist activity at EP1 receptor in human U2OS cells expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: >5.01E+4nMAssay Description:Antagonist activity at EP1 receptor in human U2OS cells expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs by FLIPR assayMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of the Phospholipase A2 (Lp-PLA2) enzyme in whole human plasmaMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.0600nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibition of lipoprotein associated phospholipase A2 in human plasmaMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.120nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.120nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.170nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2).More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2).More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2).More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.25nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.25nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2 by mechanistic studiesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of lipoprotein associated phospholipase A2 in human plasmaMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.350nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against human lipoprotein associated phospholipase A2 (Lp-PLA2)More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of lipoprotein associated phospholipase A2 in human plasmaMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of lipoprotein associated phospholipase A2 in human plasmaMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair