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Found 497 with Last Name = 'lesuisse' and Initial = 'd'
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50005878(4-Chloromethylsulfanyl-10,13-dimethyl-1,6,7,8,10,1...)
Affinity DataKi:  27nMAssay Description:Inhibition constant for human placental cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)
Affinity DataKi:  27nMAssay Description:Inhibition constant for human placental cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50005876(4-Chloromethylsulfanyl-10,13-dimethyl-1,6,7,8,9,10...)
Affinity DataKi:  30nMAssay Description:Inhibition constant for human placental cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50005874(4-Fluoromethylsulfanyl-10,13-dimethyl-1,6,7,8,9,10...)
Affinity DataKi:  30nMAssay Description:Inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50005875(4-Mercapto-10,13-dimethyl-1,6,7,8,10,12,13,14,15,1...)
Affinity DataKi:  72nMAssay Description:Inhibition constant for human placental cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM50406730(CHEMBL2113619)
Affinity DataKi:  169nMAssay Description:Inhibition constant for human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM14691(4-[(2S)-2-acetamido-2-{[(3S)-2-oxo-1-[(4-phenylphe...)
Affinity DataIC50:  0.25nMAssay Description:Inhibitory concentration against SH2 domain of human p60 Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM14691(4-[(2S)-2-acetamido-2-{[(3S)-2-oxo-1-[(4-phenylphe...)
Affinity DataIC50:  0.25nMAssay Description:Binding affinity for Src SH2 domain in scintillation proximity binding assay (SPA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src [145-252](Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM14691(4-[(2S)-2-acetamido-2-{[(3S)-2-oxo-1-[(4-phenylphe...)
Affinity DataIC50:  0.25nMAssay Description:SPA uses 125I as energy donor and scintillant-coated beads as energy acceptor. The labeled ligand is captured by the biotinylated Src-SH2 protein imm...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50080177((S)-4-{(S)-2-[(S)-2-Acetylamino-3-(4-phosphonooxy-...)
Affinity DataIC50:  1nMAssay Description:Binding affinity for Src protein tryrosine kinase SH2 domain using surface plasmon resonance (SPR) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50080177((S)-4-{(S)-2-[(S)-2-Acetylamino-3-(4-phosphonooxy-...)
Affinity DataIC50:  1nMAssay Description:Binding affinity for Src protein tryrosine kinase SH2 domain using surface plasmon resonance (SPR) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Aventis

Curated by ChEMBL
LigandPNGBDBM50366682(CHEMBL1627395)
Affinity DataIC50:  2.10nMAssay Description:Compound was tested for the inhibition of type 2 5-alpha-reductase of human prostatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50112427(CHEMBL281775 | Phosphoric acid mono-(4-{2-acetylam...)
Affinity DataIC50:  3nMAssay Description:Binding affinity towards p60 Src tyrosine kinase using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src [145-252](Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM14690(2-{2-carboxy-4-[(2S)-2-acetamido-2-{[(3S)-2-oxo-1-...)
Affinity DataIC50:  3nMAssay Description:SPA uses 125I as energy donor and scintillant-coated beads as energy acceptor. The labeled ligand is captured by the biotinylated Src-SH2 protein imm...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM14690(2-{2-carboxy-4-[(2S)-2-acetamido-2-{[(3S)-2-oxo-1-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against SH2 domain of human p60 Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src [145-252](Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM14693(({4-[(2S)-2-acetamido-2-{[(3S)-2-oxo-1-[(4-phenylp...)
Affinity DataIC50:  4nMAssay Description:SPA uses 125I as energy donor and scintillant-coated beads as energy acceptor. The labeled ligand is captured by the biotinylated Src-SH2 protein imm...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM14690(2-{2-carboxy-4-[(2S)-2-acetamido-2-{[(3S)-2-oxo-1-...)
Affinity DataIC50:  5nMAssay Description:Binding affinity towards Src protein tryrosine kinase SH2 domain using scintillation proximity binding assay (SPA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313678(CHEMBL1093747 | N-(5-bromo-6-(4-hydroxyphenyl)-1H-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM14693(({4-[(2S)-2-acetamido-2-{[(3S)-2-oxo-1-[(4-phenylp...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against SH2 domain of human p60 Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313696(CHEMBL1086427 | N-(6-chloro-7-fluoro-5-phenyl-1H-i...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)
Affinity DataIC50:  7nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 60 mins by tim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50113760(2-{4-[2-Acetylamino-2-(1-biphenyl-4-ylmethyl-2-oxo...)
Affinity DataIC50:  7nMAssay Description:Binding affinity towards Src protein tryrosine kinase SH2 domain using surface plasmon resonance (SPR) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313661(CHEMBL1095040 | N-(6-chloro-5-phenyl-1H-indazol-3-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)
Affinity DataIC50:  7nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells preincubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)
Affinity DataIC50:  7nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313662(CHEMBL1095041 | N-(5-(4-aminophenyl)-6-chloro-1H-i...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50074242((2S,3S)-2-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-ph...)
Affinity DataIC50:  9nMAssay Description:Binding affinity for Src SH2 domain in scintillation proximity binding assay (SPA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM14689(4-[(2S)-2-acetamido-2-{[(3S)-2-oxo-1-[(4-phenylphe...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against SH2 domain of human p60 Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM14689(4-[(2S)-2-acetamido-2-{[(3S)-2-oxo-1-[(4-phenylphe...)
Affinity DataIC50:  9nMAssay Description:Binding affinity towards p60 Src tyrosine kinase using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src [145-252](Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM14689(4-[(2S)-2-acetamido-2-{[(3S)-2-oxo-1-[(4-phenylphe...)
Affinity DataIC50:  9nMAssay Description:SPA uses 125I as energy donor and scintillant-coated beads as energy acceptor. The labeled ligand is captured by the biotinylated Src-SH2 protein imm...More data for this Ligand-Target Pair
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Aventis

Curated by ChEMBL
LigandPNGBDBM50101143(4'-[(Diisopropylcarbamoyl)-methoxy]-5'-fluoro-3'-n...)
Affinity DataIC50:  9.80nMAssay Description:Compound was tested for the inhibition of type 2 5-alpha-reductase of human prostatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src [145-252](Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM14692(2-{4-[(2S)-2-acetamido-2-{[(3S)-2-oxo-1-[(4-phenyl...)
Affinity DataIC50:  10nMAssay Description:SPA uses 125I as energy donor and scintillant-coated beads as energy acceptor. The labeled ligand is captured by the biotinylated Src-SH2 protein imm...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313663(CHEMBL1095366 | N-(6-chloro-5-(4-hydroxyphenyl)-1H...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313664(CHEMBL1077218 | N-(6-chloro-5-(furan-3-yl)-1H-inda...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313665(CHEMBL1077213 | N-(6-chloro-5-(4-ethylphenyl)-1H-i...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313697(CHEMBL1097003 | N-(6,7-dichloro-5-phenyl-1H-indazo...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10045((2R,15S)-15-methyl-2-[2-(methylsulfanyl)ethyl]tetr...)
Affinity DataIC50:  12nMpH: 7.2 T: 2°CAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313670(CHEMBL1089723 | N-(5-(furan-2-yl)-6-(4-hydroxyphen...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313666(CHEMBL1097694 | N-(6-chloro-5-p-tolyl-1H-indazol-3...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313667(CHEMBL1091081 | N-(6-chloro-5-(4-nitrophenyl)-1H-i...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Centre De Recherches Roussel-Uclaf

Curated by ChEMBL
LigandPNGBDBM10046((2S,15S)-15-methyl-2-[2-(methylsulfanyl)ethyl]tetr...)
Affinity DataIC50:  22nMpH: 7.2 T: 2°CAssay Description:The enzyme activity was assayed by measuring the formation of tritiated water from [1beta, 2beta-3H ]androstenedione in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313668(CHEMBL1091082 | N-(6-chloro-5-(4-fluorophenyl)-1H-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313669(CHEMBL1091083 | N-(5-(4-(benzyloxy)phenyl)-6-chlor...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50112418(CHEMBL433046 | Phosphoric acid mono-(4-{2-acetylam...)
Affinity DataIC50:  26nMAssay Description:Binding affinity towards p60 Src tyrosine kinase using scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313703(CHEMBL1082236 | N-(6-(3,4-dihydroxyphenyl)-1H-inda...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant GSK3-beta using gamma[33P]-ATP after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340502(CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...)
Affinity DataIC50:  28nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 30 mins by tim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50313664(CHEMBL1077218 | N-(6-chloro-5-(furan-3-yl)-1H-inda...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant GSK3beta by kinetic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50:  33nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 30 mins by tim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340513(2-(5,6-dimethoxy-1-methyl-1H-indol-3-yl)-1H-pyrrol...)
Affinity DataIC50:  34nMAssay Description:Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 10 mins by tim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM50340503(1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...)
Affinity DataIC50:  34nMAssay Description:Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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