Compile Data Set for Download or QSAR
maximum 50k data
Found 839 with Last Name = 'leuthner' and Initial = 'b'
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50524862(CHEMBL4475680)
Affinity DataKi:  0.160nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50524862(CHEMBL4475680)
Affinity DataKi:  0.160nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCathepsin D(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50080960(2-Bromo-N-[(1S,2S)-3-{[2-(2,4-dichloro-phenyl)-eth...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM401307(US10005756, Compound A78)
Affinity DataKi:  0.900nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM401307(US10005756, Compound A78)
Affinity DataKi:  0.900nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50531161(CHEMBL4448724)
Affinity DataKi:  3.40nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50531161(CHEMBL4448724)
Affinity DataKi:  3.40nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50531163(CHEMBL4464946)
Affinity DataKi:  4.30nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50531163(CHEMBL4464946)
Affinity DataKi:  4.30nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50505332(CHEMBL4567515)
Affinity DataKi:  6.80E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by whole cell patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50505331(CHEMBL4458129)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50593627(CHEMBL5199558)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50505332(CHEMBL4567515)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50409622(CHEMBL5272750)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50409634(CHEMBL5274873)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium bergheiMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50505331(CHEMBL4458129)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50409634(CHEMBL5274873)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50593627(CHEMBL5199558)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin D(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM232262(US9345742, 20)
Affinity DataIC50:  1nMpH: 5.5 T: 2°CAssay Description:In order to identify modulators of cathepsin D activity, a continuous enzymatic test was carried out with a synthetic peptide which carries a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50: <1nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50409619(CHEMBL5271127)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50409622(CHEMBL5272750)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50409619(CHEMBL5271127)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50505324(CHEMBL4588170)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50409626(CHEMBL5284314)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium bergheiMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50593627(CHEMBL5199558)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50505332(CHEMBL4567515)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50505324(CHEMBL4588170)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50593627(CHEMBL5199558)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium bergheiMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50505334(CHEMBL4551200)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50409618(CHEMBL5281076)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50409632(CHEMBL5279709)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50505335(CHEMBL4584689)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50505334(CHEMBL4551200)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50409623(CHEMBL5280682)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50409621(CHEMBL5269584)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50409620(CHEMBL5275576)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50505335(CHEMBL4584689)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50409621(CHEMBL5269584)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50409629(CHEMBL5269897)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50409632(CHEMBL5279709)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium bergheiMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50409624(CHEMBL5278616)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium bergheiMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50409623(CHEMBL5280682)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50505325(CHEMBL4450725)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50505325(CHEMBL4450725)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50409625(CHEMBL5280345)
Affinity DataIC50:  2.30nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium bergheiMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50409618(CHEMBL5281076)
Affinity DataIC50:  2.30nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium bergheiMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50409620(CHEMBL5275576)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50409630(CHEMBL5280167)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50409624(CHEMBL5278616)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails PubMed
Displayed 1 to 50 (of 839 total ) | Next | Last >>
Jump to: