Affinity DataKi: 0.160nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Affinity DataKi: 0.160nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Affinity DataKi: 4.30nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Affinity DataKi: 4.30nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataKi: 6.80E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by whole cell patch clamp methodMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium bergheiMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 5.5 T: 2°CAssay Description:In order to identify modulators of cathepsin D activity, a continuous enzymatic test was carried out with a synthetic peptide which carries a fluores...More data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium bergheiMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium bergheiMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium bergheiMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium bergheiMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Merck Healthcare
Curated by ChEMBL
Merck Healthcare
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium bergheiMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium bergheiMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoeaMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair