Affinity DataKi: 4nMAssay Description:Binding affinity to P2Y1 receptor in human plateletsMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.00800nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount scintillation counting metho...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.00800nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by radioligand competitive binding analy...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Displacement of 33-P-S1P from from human S1P receptor expressed in CHO cell membranes after 50 mins by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by radioligand competitive binding analy...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount scintillation counting metho...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.0140nMAssay Description:Displacement of 33-P-S1P from from human S1P receptor expressed in CHO cell membranes after 50 mins by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.0140nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by radioligand competitive binding analy...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.0160nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description:Antagonist activity at P2Y1 receptor in human platelets by FLIPR assay in presence of 2-methylthio-ADPMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.0400nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0400nMAssay Description:Antagonist activity at P2Y1 receptor in human platelets by FLIPR assay in presence of 2-methylthio-ADPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0400nMAssay Description:Antagonist activity at P2Y1 receptor in human platelets by FLIPR assay in presence of 2-methylthio-ADPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0600nMAssay Description:Antagonist activity at P2Y1 receptor in human platelets by FLIPR assay in presence of 2-methylthio-ADPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Antagonist activity at P2Y1 receptor in human platelets by FLIPR assay in presence of 2-methylthio-ADPMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: <0.100nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.110nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.110nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.120nMAssay Description:Antagonist activity at P2Y1 receptor in human platelets by FLIPR assay in presence of 2-methylthio-ADPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.130nMAssay Description:Antagonist activity at P2Y1 receptor in human platelets by FLIPR assay in presence of 2-methylthio-ADPMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:Antagonist activity at P2Y1 receptor in human platelets by FLIPR assay in presence of 2-methylthio-ADPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:Antagonist activity at P2Y1 receptor in human platelets by FLIPR assay in presence of 2-methylthio-ADPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.170nMAssay Description:Antagonist activity at P2Y1 receptor in human platelets by FLIPR assay in presence of 2-methylthio-ADPMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.210nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.210nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.230nMAssay Description:Antagonist activity at P2Y1 receptor in human platelets by FLIPR assay in presence of 2-methylthio-ADPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.370nMAssay Description:Antagonist activity at P2Y1 receptor in human platelets by FLIPR assay in presence of 2-methylthio-ADPMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.470nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.470nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.510nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.510nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.690nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.690nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Displacement of [33P]S1P from human S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount methodMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair