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Found 1802 with Last Name = 'liang' and Initial = 'c'
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50096906(CHEMBL154745 | US10227373, Compound D-3-Deazaisone...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of SAH hydrolase (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM155254(US10098888, Compound 2 | US9006242, 2)
Affinity DataKi: <3nMAssay Description:Inhibition of EZH2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))TBA
LigandPNGBDBM50611954(CHEMBL5266282)
Affinity DataKi:  145nMAssay Description:Displacement of [3H]HU243 from rat brain membrane CB1 receptor assessed as inhibition constant incubated for 90 minsMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50049391(3,5,7-Trihydroxyflavone | 3,5,7-triOH-flavone | 3,...)
Affinity DataKi:  5.90E+3nMAssay Description:Binding affinity to recombinant His-tagged full length human PDI-b' x domain substrate binding pocket expressed in Escherichia coli BL21 (DE3) cells ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))TBA
LigandPNGBDBM50318484(2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]CP55940 from rat brain membrane CB1 receptor assessed as inhibition constant incubated for 90 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50042944((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...)
Affinity DataKi:  3.61E+4nMAssay Description:Binding affinity to recombinant His-tagged full length human PDI-b' x domain substrate binding pocket expressed in Escherichia coli BL21 (DE3) cells ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50116067((Linezolid)N-[3-(3-Fluoro-4-morpholin-4-yl-phenyl)...)
Affinity DataKi:  5.30E+4nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226485((R)-3-(3-fluoro-4-(tetrahydro-2H-pyran-4-yl)phenyl...)
Affinity DataKi:  5.80E+4nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226479((R)-3-(3,5-difluoro-4-morpholinophenyl)-2-oxooxazo...)
Affinity DataKi:  6.30E+4nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226484((5R)-3-[4-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl...)
Affinity DataKi:  1.05E+5nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226480((R)-3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidi...)
Affinity DataKi:  1.46E+5nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226481((5R)-3-[4-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl...)
Affinity DataKi:  2.93E+5nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein disulfide-isomerase(Homo sapiens (Human))
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50600404(CHEMBL5201508)
Affinity DataKi:  3.09E+5nMAssay Description:Binding affinity to recombinant His-tagged full length human PDI-b' x domain substrate binding pocket expressed in Escherichia coli BL21 (DE3) cells ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226482((5R)-3-[3,5-difluoro-4-(1-oxidotetrahydro-2H-thiop...)
Affinity DataKi:  3.55E+5nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594146(CHEMBL5206842)
Affinity DataIC50:  0.00970nMAssay Description:Inhibition of wild-type EZH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594109(CHEMBL5188827)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594115(CHEMBL5172110)
Affinity DataIC50:  0.0280nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM542469(US11274095, Example 4)
Affinity DataIC50:  0.0380nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM542475(7-chloro-N-((4-chloro-6-methyl-2-oxo-1,2-dihydropy...)
Affinity DataIC50:  0.0390nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Chinese Academy Of Medical Science And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50550778(CHEMBL4741886)
Affinity DataIC50:  0.0530nMAssay Description:Inhibition of recombinant HIV1 protease measured assessed as hydrolysis of fluorogenic substrate by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Chinese Academy Of Medical Science And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  0.0910nMAssay Description:Inhibition of HIV-1BH10 reverse transcriptase expressed in Escherichia coli assessed as polymerization by real time FRET assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
The People'S Hospital Of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50593904(CHEMBL5198209)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141329(2-Benzenesulfonylamino-3-{4-[3-(1,4,5,6-tetrahydro...)
Affinity DataIC50:  0.110nMAssay Description:Binding affinity towards alpha V/beta3 receptor by solid-phase receptor binding assays (SPRA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141329(2-Benzenesulfonylamino-3-{4-[3-(1,4,5,6-tetrahydro...)
Affinity DataIC50:  0.120nMAssay Description:Binding affinity towards alpha V-beta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Chinese Academy Of Medical Science And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50550780(CHEMBL4744103)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of recombinant HIV1 protease measured assessed as hydrolysis of fluorogenic substrate by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Chinese Academy Of Medical Science And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50550777(CHEMBL4760803)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of recombinant HIV1 protease measured assessed as hydrolysis of fluorogenic substrate by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50110371(CHEMBL3605441)
Affinity DataIC50:  0.153nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141324(2-Isopropoxycarbonylamino-3-{2-methoxy-4-[3-(1,4,5...)
Affinity DataIC50:  0.160nMAssay Description:Binding affinity towards alpha V/beta3 receptor by solid-phase receptor binding assays (SPRA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Chinese Academy Of Medical Science And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50550782(CHEMBL4784196)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of recombinant HIV1 protease measured assessed as hydrolysis of fluorogenic substrate by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141309(2-Benzenesulfonylamino-3-[4-(3-guanidino-benzoylam...)
Affinity DataIC50:  0.200nMAssay Description:Binding affinity towards alpha V/beta3 receptor by solid-phase receptor binding assays (SPRA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594135(CHEMBL5188577)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of EZH2 Y641N mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141325(2-Benzenesulfonylamino-3-{4-[3-(4,5-dihydro-1H-imi...)
Affinity DataIC50:  0.270nMAssay Description:Binding affinity towards alpha V/beta3 receptor by solid-phase receptor binding assays (SPRA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141356(3-{3-Chloro-4-[3-(4,5-dihydro-1H-imidazol-2-ylamin...)
Affinity DataIC50:  0.310nMAssay Description:Binding affinity towards alpha V-beta1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141355(3-[4-(3-Guanidino-benzoylamino)-2-methoxy-phenyl]-...)
Affinity DataIC50:  0.320nMAssay Description:Binding affinity towards alpha V/beta3 receptor by solid-phase receptor binding assays (SPRA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594116(CHEMBL5185991)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141324(2-Isopropoxycarbonylamino-3-{2-methoxy-4-[3-(1,4,5...)
Affinity DataIC50:  0.350nMAssay Description:Binding affinity towards alpha V-beta1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141355(3-[4-(3-Guanidino-benzoylamino)-2-methoxy-phenyl]-...)
Affinity DataIC50:  0.380nMAssay Description:Binding affinity towards alpha V-beta1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Chinese Academy Of Medical Science And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50550807(CHEMBL4785296)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of recombinant HIV1 protease measured assessed as hydrolysis of fluorogenic substrate by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594114(CHEMBL5191375)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141324(2-Isopropoxycarbonylamino-3-{2-methoxy-4-[3-(1,4,5...)
Affinity DataIC50:  0.410nMAssay Description:Binding affinity towards alpha V-beta5 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141354(CHEMBL285192 | {2-Methoxy-4-[3-(1,4,5,6-tetrahydro...)
Affinity DataIC50:  0.430nMAssay Description:Binding affinity towards alpha V/beta3 receptor by solid-phase receptor binding assays (SPRA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of EZH1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sugen

LigandPNGBDBM5140(5-{[(5Z)-4-[(3-chloro-4-fluorophenyl)amino]-6-oxo-...)
Affinity DataIC50:  0.450nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141319(2-(2-Carboxy-vinyl)-5-[3-(1,4,5,6-tetrahydro-pyrim...)
Affinity DataIC50:  0.450nMAssay Description:Binding affinity towards alpha V-beta5 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
The People'S Hospital Of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of CDK7/Cyclin H (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141327(3-{3-Methyl-4-[3-(1,4,5,6-tetrahydro-pyrimidin-2-y...)
Affinity DataIC50:  0.460nMAssay Description:Binding affinity towards alpha V-beta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594132(CHEMBL5197386)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of EZH1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141334(3-[4-(3-Guanidino-benzoylamino)-phenyl]-2-isopropo...)
Affinity DataIC50:  0.470nMAssay Description:Binding affinity towards alpha V-beta5 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50594135(CHEMBL5188577)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141343(3-{3-Chloro-4-[3-(1,4,5,6-tetrahydro-pyrimidin-2-y...)
Affinity DataIC50:  0.480nMAssay Description:Binding affinity towards alpha V-beta1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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