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Found 159 with Last Name = 'lillini' and Initial = 's'
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309241((R)-6-(4-fluoro-3-(4-(2-methylpyrrolidine-2-carbon...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309249(6-(3-(4-(2-allylpyrrolidine-2-carbonyl)piperazine-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309229(6-(3-(4-(2-(dimethylamino)-2-methylpropanoyl)piper...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309222(6,7-dichloro-4-(4-fluoro-3-(4-(2-methyl-2-(methyla...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309234(6-(3-(4-(1-(cyclopropylmethylamino)cyclopentanecar...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309221(6,7-dichloro-4-(4-fluoro-3-(1,8-diazaspiro[4.5]dec...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309253((R)-6-(4-fluoro-3-(4-(2-(4-fluorobenzyl)pyrrolidin...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309223(6-(4-fluoro-3-(1,8-diazaspiro[4.5]decane-8-carbony...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309232(6-(4-fluoro-3-(4-(1-(methylamino)cyclopentanecarbo...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309235(6-(4-fluoro-3-(4-(1-(pyrrolidin-1-yl)cyclopentanec...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309243((R)-6-(4-fluoro-3-(4-(pyrrolidine-2-carbonyl)piper...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309239(6-(4-fluoro-3-(4-(2-methylpyrrolidine-2-carbonyl)p...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309244(6-(4-fluoro-3-(4-(2-methyltetrahydrofuran-2-carbon...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309233(6-(3-(4-(1-(ethylamino)cyclopentanecarbonyl)pipera...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309247((R)-6-(4-fluoro-3-(4-(2-methylazetidine-2-carbonyl...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309242((S)-6-(4-fluoro-3-(4-(pyrrolidine-2-carbonyl)piper...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309238(6-(3-(4-(1-(cyclopropylmethylamino)cyclobutanecarb...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309250(6-(3-(4-(2-benzylpyrrolidine-2-carbonyl)piperazine...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309237(6-(3-(4-(1-(cyclopropylmethylamino)cyclohexanecarb...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309251(6-(4-fluoro-3-(4-(2-(4-fluorobenzyl)pyrrolidine-2-...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309230(6-(4-fluoro-3-(4-(1-(methylamino)cyclopropanecarbo...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309228(6-(4-fluoro-3-(4-(2-methyl-2-(methylamino)propanoy...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309248(6-(3-(4-(2-ethylpyrrolidine-2-carbonyl)piperazine-...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309240((S)-6-(4-fluoro-3-(4-(2-methylpyrrolidine-2-carbon...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309245(6-(4-fluoro-3-(4-(pyrrolidine-3-carbonyl)piperazin...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309236(6-(4-fluoro-3-(4-(1-(phenylamino)cyclopentanecarbo...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309252((S)-6-(4-fluoro-3-(4-(2-(4-fluorobenzyl)pyrrolidin...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50615875(CHEMBL5286892)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in icilin induced Ca2+ efflux preincubated for 5 mins followed by icilin ad...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309224(6-(4-fluoro-3-(1-methyl-1,8-diazaspiro[4.5]decane-...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309227(6-(4-fluoro-3-(1,7-diazaspiro[3.5]nonane-7-carbony...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309226(6-(4-fluoro-3-(2,8-diazaspiro[4.5]decane-8-carbony...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50615875(CHEMBL5286892)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in cold stimulated Ca2+ efflux preincubated for 5 mins followed by cold sti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309231(6-(3-(4-(1-(dimethylamino)cyclopropanecarbonyl)pip...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM506987(4-hydroxy-2-(2-hydroxyphenyl)-N- methoxy-N-methyl-...)
Affinity DataIC50:  6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM506977(1-[2-(3-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in cold stimulated Ca2+ efflux preincubated for 5 mins followed by cold sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309225(6-(3-(1-ethyl-1,8-diazaspiro[4.5]decane-8-carbonyl...)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50615875(CHEMBL5286892)
Affinity DataIC50:  11nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615868(CHEMBL5285661)
Affinity DataIC50:  12nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in cold stimulated Ca2+ efflux preincubated for 5 mins followed by cold sti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309246(6-(4-fluoro-3-(4-(2-methylpiperidine-2-carbonyl)pi...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50615856(CHEMBL5290716)
Affinity DataIC50:  14nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in cold stimulated Ca2+ efflux preincubated for 5 mins followed by cold sti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615868(CHEMBL5285661)
Affinity DataIC50:  16nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50615868(CHEMBL5285661)
Affinity DataIC50:  17nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in icilin induced Ca2+ efflux preincubated for 5 mins followed by icilin ad...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613642(CHEMBL5270507)
Affinity DataIC50:  18nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM506978(2-(3-fluorophenyl)-4-hydroxy-N- methoxy-N-methyl-1...)
Affinity DataIC50:  18nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50613642(CHEMBL5270507)
Affinity DataIC50:  21nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in cold stimulated Ca2+ efflux preincubated for 5 mins followed by cold sti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM507003(1-[4-hydroxy-2-(3-hydroxyphenyl)- 1,3-thiazol-5-yl...)
Affinity DataIC50:  23nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50615856(CHEMBL5290716)
Affinity DataIC50:  24nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613642(CHEMBL5270507)
Affinity DataIC50:  24nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in icilin induced Ca2+ efflux preincubated for 5 mins followed by icilin ad...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM506976(Sodium 2-(3-fluorophenyl)-5- propanoyl-1,3-thiazol...)
Affinity DataIC50:  28nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM506977(1-[2-(3-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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