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Found 354 with Last Name = 'lindemann' and Initial = 'l'
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM511435((-)-(1R,5S)-2-[5-(2,5-Difluoro-phenylethynyl)-pyri...)
Affinity DataKi:  3nMAssay Description:For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM511433((-)-(1R,5S)-2-[5-(4-Fluoro-phenylethynyl)-pyridin-...)
Affinity DataKi:  4nMAssay Description:For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM511432((-)-(1R,5S)-2-[5-(3-Fluoro-phenylethynyl)-pyridin-...)
Affinity DataKi:  5nMAssay Description:For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM222815(US11059766, WO2011128279 Ex. 106 | US9315498, 106)
Affinity DataKi:  8nMAssay Description:For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM511431((-)-(1 S,5R)-2-methyl-4-(5-(phenylethynyl)pyridin-...)
Affinity DataKi:  9nMAssay Description:For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM224627(US9328070, 2)
Affinity DataKi:  15nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM143695(US9682959, 3 | US9751856, 3)
Affinity DataKi:  16nMAssay Description:The pharmacological activity of the compounds was tested using the following method: cDNA encoding rat mGlu 5a receptor was transiently transfected i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM143695(US9682959, 3 | US9751856, 3)
Affinity DataKi:  16nMAssay Description:cDNA encoding rat mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by E.-J. Schlaeger and K. Christensen (Cyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071369(CHEMBL3410220)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071328(CHEMBL3410213)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM143693(US9682959, 1 | US9751856, 1)
Affinity DataKi:  18nMAssay Description:cDNA encoding rat mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by E.-J. Schlaeger and K. Christensen (Cyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM143693(US9682959, 1 | US9751856, 1)
Affinity DataKi:  18nMAssay Description:The pharmacological activity of the compounds was tested using the following method: cDNA encoding rat mGlu 5a receptor was transiently transfected i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM199988(US9227959, 2)
Affinity DataKi:  19nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071375(CHEMBL3410223 | US10618900, No. CTEP)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071372(CHEMBL1946770)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM199989(US9227959, 3)
Affinity DataKi:  23nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM234211(US9359301, 2)
Affinity DataKi:  24nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071333(CHEMBL3410215)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM224626(US9328070, 1)
Affinity DataKi:  28nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM224623(US9328070, Reference compound 1 | US9359301, Refer...)
Affinity DataKi:  29nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071332(CHEMBL3410214)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM224623(US9328070, Reference compound 1 | US9359301, Refer...)
Affinity DataKi:  29nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071371(CHEMBL3410221)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071376(CHEMBL3410224)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071374(Basimglurant | RG-7090 | RO-4917523)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US11059766, WO2011128279 Ex. 109 | US9315498, 109)
Affinity DataKi:  37nMAssay Description:For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM143694(US9682959, 2 | US9751856, 2)
Affinity DataKi:  38nMAssay Description:cDNA encoding rat mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by E.-J. Schlaeger and K. Christensen (Cyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM143694(US9682959, 2 | US9751856, 2)
Affinity DataKi:  38nMAssay Description:The pharmacological activity of the compounds was tested using the following method: cDNA encoding rat mGlu 5a receptor was transiently transfected i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM224624(US9328070, Reference compound 2)
Affinity DataKi:  42nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM234210(US9359301, 1)
Affinity DataKi:  42nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM234213(US9359301, 4)
Affinity DataKi:  46nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM234209(US9359301, Reference compound 2)
Affinity DataKi:  51nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM224625(US9328070, Reference compound 3)
Affinity DataKi:  58nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM199990(US9227959, 4)
Affinity DataKi:  67nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071324(CHEMBL3410207)
Affinity DataKi:  69nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM199987(US9227959, 1)
Affinity DataKi:  72nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071322(CHEMBL3410209)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM143697(US9682959, 4 | US9751856, 4)
Affinity DataKi:  80nMAssay Description:cDNA encoding rat mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by E.-J. Schlaeger and K. Christensen (Cyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM143697(US9682959, 4 | US9751856, 4)
Affinity DataKi:  80nMAssay Description:The pharmacological activity of the compounds was tested using the following method: cDNA encoding rat mGlu 5a receptor was transiently transfected i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071335(CHEMBL3410217)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071334(CHEMBL3410216)
Affinity DataKi:  90nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM234212(US9359301, 3)
Affinity DataKi:  94nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM199985(US9227959, Reference Compound 1, Ex. 35)
Affinity DataKi:  201nMpH: 7.4Assay Description:For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071326(CHEMBL3410211)
Affinity DataKi:  213nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071367(CHEMBL3410218)
Affinity DataKi:  252nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM50071327(CHEMBL3410212)
Affinity DataKi:  255nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM143699(US9682959, 6 | US9751856, 6)
Affinity DataKi:  280nMAssay Description:The pharmacological activity of the compounds was tested using the following method: cDNA encoding rat mGlu 5a receptor was transiently transfected i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM143699(US9682959, 6 | US9751856, 6)
Affinity DataKi:  280nMAssay Description:cDNA encoding rat mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by E.-J. Schlaeger and K. Christensen (Cyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM143698(US9682959, 5 | US9751856, 5)
Affinity DataKi:  281nMAssay Description:The pharmacological activity of the compounds was tested using the following method: cDNA encoding rat mGlu 5a receptor was transiently transfected i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM143698(US9682959, 5 | US9751856, 5)
Affinity DataKi:  281nMAssay Description:cDNA encoding rat mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by E.-J. Schlaeger and K. Christensen (Cyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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