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Found 2211 with Last Name = 'linz' and Initial = 'k'
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50100983(CHEMBL3326224)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM239934(US9403767, 117)
Affinity DataKi:  0.130nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50101099(CHEMBL3326228)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50101306(CHEMBL3326229)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50100983(CHEMBL3326224)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOpioid growth factor receptor-like protein 1(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM177911(US9120797, 10 | US9120797, 9)
Affinity DataKi:  0.260nM ΔG°:  -54.7kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM469350(US10807988, Example SC_3001 | cis-5-[1-(Cyclobutyl...)
Affinity DataKi:  0.300nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOpioid growth factor receptor-like protein 1(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM177903(US9120797, 1 | US9120797, 2 | US9120797, 3)
Affinity DataKi:  0.300nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50101088(CHEMBL3326220)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]Naloxone from human mu opioid receptor receptor expressed in CHO-K1 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50100983(CHEMBL3326224)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM239934(US9403767, 117)
Affinity DataKi:  0.350nM ΔG°:  -54.0kJ/moleT: 2°CAssay Description:The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50101152(CHEMBL3326232)
Affinity DataKi:  0.360nMAssay Description:Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM177911(US9120797, 10 | US9120797, 9)
Affinity DataKi:  0.360nM ΔG°:  -53.9kJ/moleT: 2°CAssay Description:The receptor affinity for the human mu-opiate receptor was determined in a homogeneous batch in microtitre plates. For this, dilution series of the p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50101099(CHEMBL3326228)
Affinity DataKi:  0.390nMAssay Description:Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM469352(US10807988, Example SC_3003 | cis-5-[1-(Cyclobutyl...)
Affinity DataKi:  0.400nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM239911(US9403767, 76 | US9403767, 77)
Affinity DataKi:  0.400nM ΔG°:  -53.6kJ/moleT: 2°CAssay Description:The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50101096(CHEMBL3325961)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM469875(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Affinity DataKi:  0.400nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM464662(CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-8-pheny...)
Affinity DataKi:  0.400nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50101091(CHEMBL3326223)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM469376(US10807988, Example SC_3022 | cis-1-(Cyclobutyl-me...)
Affinity DataKi:  0.400nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM472033(US10829480, Example SC_2061)
Affinity DataKi:  0.5nMAssay Description:Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOpioid growth factor receptor-like protein 1(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM177935(US9120797, 33)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM177935(US9120797, 33)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/moleT: 2°CAssay Description:The receptor affinity for the human mu-opiate receptor was determined in a homogeneous batch in microtitre plates. For this, dilution series of the p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM469999(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Affinity DataKi:  0.5nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPrepronociceptin(Human)
GrÜNenthal

US Patent
LigandPNGBDBM464503(US10793528, Example SC_5078)
Affinity DataKi:  0.5nMAssay Description:NOP:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50100991(CHEMBL3325879)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50101088(CHEMBL3326220)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM239921(US9403767, 99)
Affinity DataKi:  0.540nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50101306(CHEMBL3326229)
Affinity DataKi:  0.550nMAssay Description:Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50100983(CHEMBL3326224)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]Naloxone from human mu opioid receptor receptor expressed in CHO-K1 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM177955(US9120797, 53)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/moleT: 2°CAssay Description:The receptor affinity for the human mu-opiate receptor was determined in a homogeneous batch in microtitre plates. For this, dilution series of the p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM177903(US9120797, 1 | US9120797, 2 | US9120797, 3)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/moleT: 2°CAssay Description:The receptor affinity for the human mu-opiate receptor was determined in a homogeneous batch in microtitre plates. For this, dilution series of the p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOpioid growth factor receptor-like protein 1(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM177903(US9120797, 1 | US9120797, 2 | US9120797, 3)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/molepH: 7.4 T: 2°CAssay Description:The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM469437(US10807988, Example SC_3078 | cis-5-[1-(Cyclobutyl...)
Affinity DataKi:  0.600nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM469435(US10807988, Example SC_3076 | cis-1-(Cyclobutyl-me...)
Affinity DataKi:  0.600nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM469382(US10807988, Example SC_3028 | cis-4-[1-(Cyclobutyl...)
Affinity DataKi:  0.600nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM469357(US10807988, Example SC_3008 | cis-2-[1-(Cyclobutyl...)
Affinity DataKi:  0.600nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM239925(US9403767, 104 | US9403767, 105)
Affinity DataKi:  0.650nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM469354(US10807988, Example SC_3005 | cis-5-[1-(Cyclobutyl...)
Affinity DataKi:  0.700nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM177936(US9120797, 34)
Affinity DataKi:  0.700nM ΔG°:  -52.3kJ/moleT: 2°CAssay Description:The receptor affinity for the human mu-opiate receptor was determined in a homogeneous batch in microtitre plates. For this, dilution series of the p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM469419(US10807988, Example SC_3063 | cis-5-[1-[(1-Cyano-c...)
Affinity DataKi:  0.700nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50100993(CHEMBL3325881)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]Naloxone from human mu opioid receptor receptor expressed in CHO-K1 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM50101095(CHEMBL3325957)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM239911(US9403767, 76 | US9403767, 77)
Affinity DataKi:  0.710nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM472098(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[(3-me...)
Affinity DataKi:  0.800nMAssay Description:Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM469822(CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo...)
Affinity DataKi:  0.800nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM469365(US10807988, Example SC_3014 | cis-2-[1-(Cyclobutyl...)
Affinity DataKi:  0.800nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM469848(CIS-6-[[2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2...)
Affinity DataKi:  0.800nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Pharmacokinetics

Curated by ChEMBL
LigandPNGBDBM472009(CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl...)
Affinity DataKi:  0.800nMAssay Description:Mu-Opioid Peptide (hMOP): The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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