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Found 546 with Last Name = 'lopez' and Initial = 'l'
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50083197(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-az...)
Affinity DataKi:  0.290nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50000492((zacopride)4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  0.420nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataKi:  1.30nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50083192(1H-Benzoimidazole-4-carboxylic acid (1-aza-bicyclo...)
Affinity DataKi:  3.70nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50083178(6-Chloro-1H-benzoimidazole-4-carboxylic acid 9-met...)
Affinity DataKi:  4.90nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50083187(1H-Benzoimidazole-4-carboxylic acid (9-methyl-9-az...)
Affinity DataKi:  6.10nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50083185(6-Chloro-1H-benzoimidazole-4-carboxylic acid 1-aza...)
Affinity DataKi:  9.30nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50105630(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-me...)
Affinity DataKi:  30nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50105630(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-me...)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50108392((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50083175(1H-Benzoimidazole-4-carboxylic acid 9-methyl-9-aza...)
Affinity DataKi:  129nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50105651(1H-Benzoimidazole-4-carboxylic acid (1-methyl-pipe...)
Affinity DataKi:  145nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50083189(6-Chloro-1H-benzoimidazole-4-carboxylic acid (9-me...)
Affinity DataKi:  154nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50000492((zacopride)4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  158nMAssay Description:Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50083189(6-Chloro-1H-benzoimidazole-4-carboxylic acid (9-me...)
Affinity DataKi:  167nMAssay Description:Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50083197(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-az...)
Affinity DataKi:  168nMAssay Description:Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50083179(1H-Benzoimidazole-4-carboxylic acid 1-aza-bicyclo[...)
Affinity DataKi:  185nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50083185(6-Chloro-1H-benzoimidazole-4-carboxylic acid 1-aza...)
Affinity DataKi:  440nMAssay Description:Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50105651(1H-Benzoimidazole-4-carboxylic acid (1-methyl-pipe...)
Affinity DataKi:  719nMAssay Description:Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50083178(6-Chloro-1H-benzoimidazole-4-carboxylic acid 9-met...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50083192(1H-Benzoimidazole-4-carboxylic acid (1-aza-bicyclo...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50083187(1H-Benzoimidazole-4-carboxylic acid (9-methyl-9-az...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50105632(1H-Benzoimidazole-4-carboxylic acid 1-methyl-piper...)
Affinity DataKi: >1.00E+3nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50083179(1H-Benzoimidazole-4-carboxylic acid 1-aza-bicyclo[...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50105632(1H-Benzoimidazole-4-carboxylic acid 1-methyl-piper...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50083175(1H-Benzoimidazole-4-carboxylic acid 9-methyl-9-aza...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]GR-113808 from rat striatum 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataKi:  1.10E+7nMAssay Description:Displacement of [3H]DPCPX from adenosine A1 receptor in rat membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063895(CHEMBL3403631)
Affinity DataIC50:  0.230nMAssay Description:Agonist activity at human S1P1 receptor assessed as change in cAMP level by homogeneous time resolved fluorescence cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50063895(CHEMBL3403631)
Affinity DataIC50:  0.230nMAssay Description:Agonist activity at human S1P1 receptor assessed as change in cAMP level by homogeneous time resolved fluorescence cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of wild type EGFR (unknown origin) by bioluminescent ADP-glo kinase assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041691(CHEMBL3358920 | US11149292, Compound (R)-2-(7-(4-c...)
Affinity DataIC50:  1.90nMAssay Description:Induction of internalization of HA-tagged human S1P1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50517548(CHEMBL4460381)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of wild type EGFR (unknown origin) by bioluminescent ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137185((1H-Indol-5-yl)-(6-phenyl-thieno[3,2-d]pyrimidin-4...)
Affinity DataIC50:  3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50517546(CHEMBL4473768)
Affinity DataIC50:  10nMAssay Description:Inhibition of wild type EGFR (unknown origin) by bioluminescent ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50589184(CHEMBL5177673)
Affinity DataIC50:  12nMAssay Description:Inhibition of AXL (unknown origin) using peptide substrate in presence of ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM332700(US10196378, Compound C03)
Affinity DataIC50:  16nMAssay Description:Inhibition of NanoLuc-tagged ABL1 wild type (unknown origin) expressed in HEK293 cells by NanoBRET TE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50517547(CHEMBL4541014)
Affinity DataIC50:  23nMAssay Description:Inhibition of wild type EGFR (unknown origin) by bioluminescent ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50517542(CHEMBL4569885)
Affinity DataIC50:  30nMAssay Description:Inhibition of wild type EGFR (unknown origin) by bioluminescent ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM332702(US10196378, Compound C05)
Affinity DataIC50:  38nMAssay Description:Inhibition of NanoLuc-tagged ABL1 wild type (unknown origin) expressed in HEK293 cells by NanoBRET TE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50517545(CHEMBL4546122)
Affinity DataIC50:  52nMAssay Description:Inhibition of wild type EGFR (unknown origin) by bioluminescent ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM332705(US10196378, Compound C08)
Affinity DataIC50:  65nMAssay Description:Inhibition of NanoLuc-tagged ABL1 wild type (unknown origin) expressed in HEK293 cells by NanoBRET TE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137185((1H-Indol-5-yl)-(6-phenyl-thieno[3,2-d]pyrimidin-4...)
Affinity DataIC50:  80nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137204((2-Methyl-1H-indol-5-yl)-(6-phenyl-thieno[3,2-d]py...)
Affinity DataIC50:  100nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137204((2-Methyl-1H-indol-5-yl)-(6-phenyl-thieno[3,2-d]py...)
Affinity DataIC50:  140nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  140nMAssay Description:Inhibition of wild type EGFR (unknown origin) by bioluminescent ADP-glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyketide synthase Pks13(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50582194(CHEMBL5085116)
Affinity DataIC50:  150nMAssay Description:Inhibition of Mycobacterium tuberculosis Pks13-TE domain using 4-methylumbelliferyl heptanoate as a fluorogenic substrate measured for 110 mins at 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyketide synthase Pks13(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50582205(CHEMBL5094563)
Affinity DataIC50:  150nMAssay Description:Inhibition of Mycobacterium tuberculosis Pks13-TE domain using 4-methylumbelliferyl heptanoate as a fluorogenic substrate measured for 110 mins at 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyketide synthase Pks13(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50582183(CHEMBL5080207)
Affinity DataIC50:  170nMAssay Description:Inhibition of Mycobacterium tuberculosis Pks13-TE domain using 4-methylumbelliferyl heptanoate as a fluorogenic substrate measured for 110 mins at 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyketide synthase Pks13(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50582170(CHEMBL5074531)
Affinity DataIC50:  180nMAssay Description:Inhibition of Mycobacterium tuberculosis Pks13-TE domain using 4-methylumbelliferyl heptanoate as a fluorogenic substrate measured for 110 mins at 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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