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Found 114 with Last Name = 'lu' and Initial = 'jy'
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512539(CHEMBL4466170)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512543(CHEMBL4546564)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512535(CHEMBL4435424)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512536(CHEMBL4446784)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512537(CHEMBL4474736)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Homo sapiens)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512537(CHEMBL4474736)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512533(CHEMBL4575750)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512534(CHEMBL4578218)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512530(CHEMBL4546431)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512529(CHEMBL4436619)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512531(CHEMBL4577192)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512528(CHEMBL4590521)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512540(CHEMBL4444793)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512541(CHEMBL4571849)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512542(CHEMBL4445120)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512527(CHEMBL4529094)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512532(CHEMBL4444063)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPendrin(Mus musculus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50512538(CHEMBL4576357)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299669((R)-1-phenyl-N-((4-phenyl-1H-imidazol-2-yl)methyl)...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299670((R)-3-(2-chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl...)
Affinity DataEC50:  194nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299671((R)-N-((1-methyl-4-phenyl-1H-imidazol-2-yl)methyl)...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299672((R)-1-phenyl-N-((2-phenyl-1,3-thiazol-5-yl)methyl)...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299673((R)-1-phenyl-N-((4-phenyl-1,3-oxazol-2-yl)methyl)e...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299674((R)-1-phenyl-N-((4-phenyl-1,3-thiazol-2-yl)methyl)...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299675((1R)-1-phenyl-N-((1-phenyl-1H-pyrazol-3-yl)methyl)...)
Affinity DataEC50:  1.58E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299676((1R)-1-phenyl-N-((1R)-1-(1-(4-(trifluoromethyl)phe...)
Affinity DataEC50:  233nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299677((1R)-N-((1R)-1-phenylethyl)-1-(1-(4-(trifluorometh...)
Affinity DataEC50:  1.18E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299678((1R)-2-methyl-N-((1R)-1-phenylethyl)-1-(1-(4-(trif...)
Affinity DataEC50:  2.34E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299679((1R)-1-(3-fluorophenyl)-N-((1-(4-(trifluoromethyl)...)
Affinity DataEC50:  148nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299680((1R)-1-(3-chlorophenyl)-N-((1-(4-(trifluoromethyl)...)
Affinity DataEC50:  92nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299681((R)-N-((R)-1-(5-methoxy-1-(4-(trifluoromethyl)phen...)
Affinity DataEC50:  70nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299682((1R)-1-(3-chlorophenyl)-N-((1R)-1-(5-methoxy-1-(4-...)
Affinity DataEC50:  41nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299683(1(R)-1-(1-(4-bromophenyl)-5-methoxy-1H-pyrazol-3-y...)
Affinity DataEC50:  23nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299684((1R)-1-(3-chlorophenyl)-N-((1R)-1-(1-(3-chlorophen...)
Affinity DataEC50:  57nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299685(4-(3-((R)-1-((R)-1-(3-chlorophenyl)ethylamino)ethy...)
Affinity DataEC50:  1.92E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50299686((R)-1-(1-(4-(1H-tetrazol-5-yl)phenyl)-5-methoxy-1H...)
Affinity DataEC50: >5.00E+3nMAssay Description:Activity at human CaSR expressed in HEK293 cells assessed as calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325724((R)-1-phenyl-N-((6-(trifluoromethoxy)-4'-(trifluor...)
Affinity DataEC50: >5.00E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in absence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325725((R)-N-benzyl-1-(3-methoxyphenyl)ethanamine | CHEMB...)
Affinity DataEC50:  1.20E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325726((R)-N-(2-chlorobenzyl)-1-(3-methoxyphenyl)ethanami...)
Affinity DataEC50:  3.70E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325727((R)-N-((2'-chlorobiphenyl-3-yl)methyl)-1-(3-methox...)
Affinity DataEC50:  350nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325728((R)-N-(4-methoxybenzyl)-1-(3-methoxyphenyl)ethanam...)
Affinity DataEC50:  370nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325729((R)-N-((2'-fluorobiphenyl-3-yl)methyl)-1-(3-methox...)
Affinity DataEC50:  2.70E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325730((R)-1-(3-methoxyphenyl)-N-((2'-methylbiphenyl-3-yl...)
Affinity DataEC50:  2.20E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325731((R)-N-((2'-methoxybiphenyl-3-yl)methyl)-1-(3-metho...)
Affinity DataEC50:  1.40E+3nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325732((R)-N-((4'-methoxybiphenyl-3-yl)methyl)-1-(3-metho...)
Affinity DataEC50:  870nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325733((R)-1-(3-methoxyphenyl)-N-((4'-(trifluoromethyl)bi...)
Affinity DataEC50:  620nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325734((R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-y...)
Affinity DataEC50:  23nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325735((R)-N-((6-methoxy-4'-(trifluoromethyl)biphenyl-3-y...)
Affinity DataEC50:  27nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325736((R)-1-(3-fluorophenyl)-N-((6-methoxy-4'-(trifluoro...)
Affinity DataEC50:  37nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50325737(CHEMBL1224343 | N-((6-methoxy-4'-(trifluoromethyl)...)
Affinity DataEC50:  160nMAssay Description:Positive allosteric modulation of calcium sensing receptor by FLIPR assay in presence of extracellular calciumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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