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Found 250 with Last Name = 'macpherson' and Initial = 'dt'
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataKi: <1.00E+4nMAssay Description:Inhibition of MAO-A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50505255(BIIB-074 | BIIB074 | CNV-1014802 | CNV1014802 | GS...)
Affinity DataIC50:  4nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082218((2R,3S)-2-Benzo[b]thiophen-2-ylmethyl-N*1*-((S)-1-...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082225((2R,3S)-N*4*-((S)-1-Carbamoyl-2,2-dimethyl-propyl)...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082226((2R,3S)-N*4*-((S)-1-Carbamoyl-2,2-dimethyl-propyl)...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50403719(CHEMBL2111687)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50403718(CHEMBL2112477)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082221((2R,3S)-N*1*-((S)-1-Carbamoyl-2,2-dimethyl-propyl)...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082214((2R,3S)-2-Benzofuran-2-ylmethyl-3,N*4*-dihydroxy-N...)
Affinity DataIC50: <100nMAssay Description:Inhibitory activity against matrix metalloprotease (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082216((2R,3S)-N*1*-((S)-1-Carbamoyl-2-phenyl-ethyl)-2-(7...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082214((2R,3S)-2-Benzofuran-2-ylmethyl-3,N*4*-dihydroxy-N...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082218((2R,3S)-2-Benzo[b]thiophen-2-ylmethyl-N*1*-((S)-1-...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against matrix metalloproteinase(MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082225((2R,3S)-N*4*-((S)-1-Carbamoyl-2,2-dimethyl-propyl)...)
Affinity DataIC50:  190nMAssay Description:Inhibitory activity against matrix metalloproteinase(MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50344942(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli using diethoxyfluorescein substrate measured in 25 to 30 mins by time dependent inhibition a...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254851(3-Cyclohexyl-1-[4'-((3R,5S)-3,5-dimethyl-piperazin...)
Affinity DataIC50:  200nMAssay Description:Inhibition of CYP3A4 (unknown origin) using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082220((2R,3S)-N*1*-((S)-1-Carbamoyl-2-phenyl-ethyl)-2-(6...)
Affinity DataIC50:  220nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082229((2R,3S)-N*4*-((S)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataIC50:  230nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50403718(CHEMBL2112477)
Affinity DataIC50:  230nMAssay Description:Inhibition of matrix metalloproteinase(MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50403718(CHEMBL2112477)
Affinity DataIC50:  230nMAssay Description:Inhibitory activity against matrix metalloproteinase(MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082227((2R,3S)-2-Benzothiazol-2-ylmethyl-N*1*-((S)-1-carb...)
Affinity DataIC50:  320nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082217((2R,3S)-2,N*1*-Dihydroxy-N*4*-((S)-1-methylcarbamo...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254851(3-Cyclohexyl-1-[4'-((3R,5S)-3,5-dimethyl-piperazin...)
Affinity DataIC50:  400nMAssay Description:Inhibition of CYP3A4 (unknown origin) using phenylpiperazinylmethylbenzylresofurin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50403719(CHEMBL2111687)
Affinity DataIC50:  410nMAssay Description:Inhibitory activity against matrix metalloproteinase(MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254968(CHEMBL479418 | [4'-((3R,5S)-3,5-Dimethyl-piperazin...)
Affinity DataIC50:  500nMAssay Description:Inhibition of CYP3A4 (unknown origin) using phenylpiperazinylmethylbenzylresofurin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082227((2R,3S)-2-Benzothiazol-2-ylmethyl-N*1*-((S)-1-carb...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against matrix metalloproteinase(MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082215((2R,3S)-N*4*-((S)-1-Carbamoyl-2-phenyl-ethyl)-2,N*...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254968(CHEMBL479418 | [4'-((3R,5S)-3,5-Dimethyl-piperazin...)
Affinity DataIC50:  600nMAssay Description:Inhibition of CYP3A4 (unknown origin) using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082226((2R,3S)-N*4*-((S)-1-Carbamoyl-2,2-dimethyl-propyl)...)
Affinity DataIC50:  640nMAssay Description:Inhibitory activity against matrix metalloproteinase(MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082224((2R,3S)-N*4*-((S)-1-Carbamoyl-2-phenyl-ethyl)-2,N*...)
Affinity DataIC50:  760nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50403718(CHEMBL2112477)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against matrix metalloproteinase(MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082220((2R,3S)-N*1*-((S)-1-Carbamoyl-2-phenyl-ethyl)-2-(6...)
Affinity DataIC50:  850nMAssay Description:Inhibitory activity against matrix metalloproteinase(MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254931(4'-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-bip...)
Affinity DataIC50:  900nMAssay Description:Inhibition of CYP3A4 (unknown origin) using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069587((R)-N*1*-((S)-1-Benzylcarbamoyl-2-phenyl-ethyl)-N*...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082230((2R,3S)-N*1*-((S)-1-Carbamoyl-2,2-dimethyl-propyl)...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069587((R)-N*1*-((S)-1-Benzylcarbamoyl-2-phenyl-ethyl)-N*...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against matrix metalloproteinase(MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082217((2R,3S)-2,N*1*-Dihydroxy-N*4*-((S)-1-methylcarbamo...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against matrix metalloproteinase(MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082228((2R,3S)-N*4*-((S)-1-Carbamoyl-2,2-dimethyl-propyl)...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082231((2R,3S)-2-Benzo[b]thiophen-3-ylmethyl-3,N*4*-dihyd...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082229((2R,3S)-N*4*-((S)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against matrix metalloproteinase(MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254892(2-(3-Chloro-phenyl)-N-[4'-((3R,5S)-3,5-dimethyl-pi...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50247157((3-(4-(((3R,5S)-3,5-dimethylpiperazin-1-yl)methyl)...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli using diethoxyfluorescein substrate measured in 25 to 30 mins by time dependent inhibition a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254892(2-(3-Chloro-phenyl)-N-[4'-((3R,5S)-3,5-dimethyl-pi...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using phenylpiperazinylmethylbenzylresofurin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254931(4'-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-bip...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using phenylpiperazinylmethylbenzylresofurin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50403719(CHEMBL2111687)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory activity against matrix metalloproteinase(MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50344942(CHEMBL532 | E-MYCIN E | ERYTHROMYCIN | ERYTHROMYCI...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli using diethoxyfluorescein substrate measured in 0 to 5 mins by time dependent inhibition ass...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50254893(2-Benzenesulfonyl-N-[4'-((3R,5S)-3,5-dimethyl-pipe...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082220((2R,3S)-N*1*-((S)-1-Carbamoyl-2-phenyl-ethyl)-2-(6...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of matrix metalloproteinase(MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50082225((2R,3S)-N*4*-((S)-1-Carbamoyl-2,2-dimethyl-propyl)...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of matrix metalloproteinase(MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544671(CHEMBL4644347)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Convergence Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544669(CHEMBL4647249)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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