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Found 198 with Last Name = 'maguire' and Initial = 'mp'
TargetMelanocortin receptor 4(Mus musculus)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142891(2-{2-[2-(5-Bromo-2-methoxy-phenyl)-ethyl]-phenyl}-...)
Affinity DataKi:  39nMAssay Description:Antagonistic activity of the compound was determined against mice melanocortin 4 receptor using [125I]-[NDP]-R-MSH as radioligand in a membranefiltra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142894(2-[2-(5-Bromo-2-methoxy-benzylsulfanyl)-phenyl]-1,...)
Affinity DataKi:  67nMAssay Description:Antagonistic activity of the compound was determined against mice melanocortin 4 receptor using [125I]-[NDP]-R-MSH as radioligand in a membranefiltra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142895(2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-...)
Affinity DataKi:  160nMAssay Description:Antagonistic activity of the compound was determined against mice melanocortin 4 receptor using [125I]-[NDP]-R-MSH as radioligand in a membranefiltra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142897(2-{2-[2-(5-Bromo-2-methoxy-phenyl)-ethyl]-phenyl}-...)
Affinity DataKi:  220nMAssay Description:Antagonistic activity of the compound was determined against mice melanocortin 4 receptor using [125I]-[NDP]-R-MSH as radioligand in a membranefiltra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142893(2-[2-(2,5-Dichloro-thiophen-3-ylmethylsulfanyl)-ph...)
Affinity DataKi:  2.20E+3nMAssay Description:Antagonistic activity of the compound was determined against mice melanocortin 4 receptor using [125I]-[NDP]-R-MSH as radioligand in a membranefiltra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142896(2-[2-(2-Chloro-6-fluoro-benzylsulfanyl)-phenyl]-1,...)
Affinity DataKi:  2.70E+3nMAssay Description:Antagonistic activity of the compound was determined against mice melanocortin 4 receptor using [125I]-[NDP]-R-MSH as radioligand in a membranefiltra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50142892(2-[2-(2,6-Difluoro-benzylsulfanyl)-phenyl]-1,4,5,6...)
Affinity DataKi:  1.58E+4nMAssay Description:Antagonistic activity of the compound was determined against mice melanocortin 4 receptor using [125I]-[NDP]-R-MSH as radioligand in a membranefiltra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132388((3-Chloro-phenyl)-(6,7-dimethoxy-quinoxalin-2-yl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039073(5,7-Dimethyl-3-thiophen-3-yl-quinoline | CHEMBL304...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.001-0.005More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039087(3-(3-Fluoro-4-methoxy-phenyl)-6,7-dimethoxy-quinol...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.003-0.005More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039041(6,7-Dimethoxy-3-((E)-styryl)-quinoline | CHEMBL701...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.001-0.005More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132386((6,7-Dimethoxy-quinoxalin-2-yl)-phenyl-amine | CHE...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039071(6,7-Dimethoxy-3-(4-methoxy-phenyl)-quinoline | CHE...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.001-0.015More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039082(6,7-Dimethoxy-3-thiophen-3-yl-quinoline | CHEMBL66...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.01-0.02More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132392((+/-)Bicyclo[2.2.1]hept-2-yl-(6,7-dimethoxy-quinox...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039047(5-Fluoro-3-thiophen-3-yl-quinoline | CHEMBL305056)
Affinity DataIC50:  20nMAssay Description:Inhibition of isolated human PDGF receptor phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50404045(CHEMBL2112463)
Affinity DataIC50:  25nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039069(7-Fluoro-3-thiophen-3-yl-quinoline | CHEMBL307093)
Affinity DataIC50:  25nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.004-0.025More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039084(3-(3-Fluoro-phenyl)-6,7-dimethoxy-quinoline | CHEM...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.015-0.025More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039072(3-(5-Chloro-thiophen-2-yl)-6,7-dimethoxy-quinoline...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.007-0.03More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039067(5-(6,7-Dimethoxy-quinolin-3-yl)-1H-pyridin-2-one |...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.015-0.03More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039037(4-(6,7-Dimethoxy-quinolin-3-yl)-phenol | CHEMBL303...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.02-0.03More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039042(5,7-Dimethoxy-3-thiophen-3-yl-quinoline | CHEMBL66...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.025-0.03More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039090(3-Cyclopent-1-enyl-6,7-dimethoxy-quinoline | CHEMB...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.02-0.04More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132395((6,7-Dimethoxy-quinoxalin-2-yl)-(3-methyl-cyclohex...)
Affinity DataIC50:  41nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132387((7-Methoxy-quinoxalin-2-yl)-phenyl-amine | CHEMBL1...)
Affinity DataIC50:  42nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039094(6,7-Dimethoxy-3-phenylethynyl-quinoline | CHEMBL67...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.02-0.05More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  50nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039057(7-Methoxy-3-thiophen-3-yl-quinoline | CHEMBL68185)
Affinity DataIC50:  60nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.002-0.06More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039044(3-(4-Fluoro-phenyl)-6,7-dimethoxy-quinoline | CHEM...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.035-0.06More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132384(2-Cyclohexyloxy-6,7-dimethoxy-quinoxaline | CHEMBL...)
Affinity DataIC50:  65nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039062(6,7-Dimethoxy-3-(6-methoxy-pyridin-3-yl)-quinoline...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.008-0.07More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039065(3-Benzyloxy-6,7-dimethoxy-quinoline | CHEMBL66932)
Affinity DataIC50:  70nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.04-0.07More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039075(6-Methoxy-3-thiophen-3-yl-quinoline | CHEMBL303184)
Affinity DataIC50:  70nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.05-0.07More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132391(4-((R)-6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohe...)
Affinity DataIC50:  76nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039056(Benzyl-(6,7-dimethoxy-quinolin-3-yl)-amine | CHEMB...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.02-0.08More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039079(6,7-Dimethoxy-3-thiophen-2-yl-quinoline | CHEMBL30...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.04-0.08More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132401(Benzyl-(6,7-dimethoxy-quinoxalin-2-yl)-amine | CHE...)
Affinity DataIC50:  92nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132385(CHEMBL104473 | Cyclohexyl-(6,7-dimethoxy-quinolin-...)
Affinity DataIC50:  96nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039052(6,7-Dimethoxy-3-[(E)-2-(4-methoxy-phenyl)-vinyl]-q...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.03-0.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291107((3-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-...)
Affinity DataIC50:  100nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132399(CHEMBL107402 | Cyclohexyl-(6,7-dimethoxy-quinoxali...)
Affinity DataIC50:  124nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132402(CHEMBL104616 | Cyclopentyl-(6,7-dimethoxy-quinoxal...)
Affinity DataIC50:  128nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039054(6,7-Dimethoxy-3-phenyl-quinoline | CHEMBL66063)
Affinity DataIC50:  150nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.07-0.15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039058(6,7-Dimethoxy-3-(4-nitro-phenyl)-quinoline | CHEMB...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.07-0.15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132394(2-Cyclopentyloxy-6,7-dimethoxy-quinoxaline | CHEMB...)
Affinity DataIC50:  159nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291110(CHEMBL136011 | Methyl-(1H-pyrazolo[3,4-d]pyrimidin...)
Affinity DataIC50:  180nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291111((6,7-Dimethoxy-quinazolin-4-yl)-methyl-m-tolyl-ami...)
Affinity DataIC50:  180nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039055(4-(6,7-Dimethoxy-quinolin-3-yl)-benzoic acid ethyl...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.1-0.2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50039086(3-(3,4-Difluoro-phenyl)-6,7-dimethoxy-quinoline | ...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human PDGF receptor phosphorylation; 0.09-0.2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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