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Found 240 with Last Name = 'mares' and Initial = 'm'
TargetAmyloid-beta precursor protein(Homo sapiens (Human))TBA
LigandPNGBDBM50609391(CHEMBL5271649)
Affinity DataKi:  100nMAssay Description:Binding affinity to human brain homogenate amyloid beta by radioligand competition binding assayMore data for this Ligand-Target Pair
Ligand Info
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TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))TBA
LigandPNGBDBM50609382(CHEMBL5274547)
Affinity DataKi:  110nMAssay Description:Inhibition of recombinant human MAO-A using p-tyramine as substrate by Amplex-Red MAO assayMore data for this Ligand-Target Pair
Ligand Info
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TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))TBA
LigandPNGBDBM50609382(CHEMBL5274547)
Affinity DataKi:  200nMAssay Description:Inhibition of recombinant human MAO-B using p-tyramine as substrate by Amplex-Red MAO assayMore data for this Ligand-Target Pair
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))TBA
LigandPNGBDBM50390102(CHEMBL2069433)
Affinity DataKi:  240nMAssay Description:Binding affinity to human brain homogenate amyloid beta by radioligand competition binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosinase(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs

Curated by ChEMBL
LigandPNGBDBM50205807(CHEMBL3978212)
Affinity DataKi:  350nMAssay Description:Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))TBA
LigandPNGBDBM50439491(AUREUSIDIN)
Affinity DataKi:  800nMAssay Description:Inhibition of human HDAC4 in HeLa cells extract incubated for 5 mins followed by substrate addition and measured after 15 mins using Fluor-de-Lys as ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosinase(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs

Curated by ChEMBL
LigandPNGBDBM50205815(CHEMBL3907670)
Affinity DataKi:  1.02E+3nMAssay Description:Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs

Curated by ChEMBL
LigandPNGBDBM50205806(CHEMBL3969839)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50439491(AUREUSIDIN)
Affinity DataKi:  1.66E+3nMAssay Description:Inhibition of human HDAC8 in HeLa cells extract incubated for 5 mins followed by substrate addition and measured after 15 mins using Fluor-de-Lys as ...More data for this Ligand-Target Pair
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TargetHistone deacetylase 7(Homo sapiens (Human))TBA
LigandPNGBDBM50439491(AUREUSIDIN)
Affinity DataKi:  1.66E+3nMAssay Description:Inhibition of human HDAC7 in HeLa cells extract incubated for 5 mins followed by substrate addition and measured after 15 mins using Fluor-de-Lys as ...More data for this Ligand-Target Pair
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TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50439491(AUREUSIDIN)
Affinity DataKi:  1.66E+3nMAssay Description:Inhibition of human HDAC2 in HeLa cells extract incubated for 5 mins followed by substrate addition and measured after 15 mins using Fluor-de-Lys as ...More data for this Ligand-Target Pair
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TargetTyrosinase(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs

Curated by ChEMBL
LigandPNGBDBM50205814(CHEMBL3898657)
Affinity DataKi:  1.28E+5nMAssay Description:Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Univ. Grenoble-Alpes/Cnrs

Curated by ChEMBL
LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataKi:  3.50E+5nMAssay Description:Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))TBA
LigandPNGBDBM50609384(CHEMBL5278614)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of recombinant human MAO-B assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate incubated for 20 mins by f...More data for this Ligand-Target Pair
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TargetCasein kinase II subunit alpha 3(Homo sapiens)TBA
LigandPNGBDBM50609381(CHEMBL5276409)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of recombinant human CK2 using RRRDDDSDDD as substrate in presence of [gamma-33P-ATP] incubated for 20 mins by beta-counter analysisMore data for this Ligand-Target Pair
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TargetTubulin beta chain(Sus scrofa)TBA
LigandPNGBDBM50014846((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of porcine brain tubulin polymerization preincubated for 1 mins followed by GTP addition and measured for 60 mins at 1 min interval by flu...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))TBA
LigandPNGBDBM50009279(CHEMBL2220507)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human MAO-AMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))TBA
LigandPNGBDBM50609385(CHEMBL5283208)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human MAO-BMore data for this Ligand-Target Pair
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TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50609374(CHEMBL5274383)
Affinity DataIC50:  34nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 30 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
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TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))TBA
LigandPNGBDBM195569((2E)-2-[(5-Bromofuran-2-yl)methylidene]-5-methoxy-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human MAO-B assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate incubated for 20 mins by f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))TBA
LigandPNGBDBM50609386(CHEMBL5281190)
Affinity DataIC50:  52nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
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LigandPNGBDBM50609380(CHEMBL5269374)
Affinity DataIC50:  66nMAssay Description:Inhibition of AKT (unknown origin) by by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
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TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50609375(CHEMBL5316035)
Affinity DataIC50:  150nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate incubated for 30 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand Info
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TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))TBA
LigandPNGBDBM195569((2E)-2-[(5-Bromofuran-2-yl)methylidene]-5-methoxy-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant human MAO-A assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate incubated for 20 mins by f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50609379(CHEMBL5270720)
Affinity DataIC50:  207nMAssay Description:Inhibition of AKT (unknown origin)More data for this Ligand-Target Pair
Ligand Info
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TargetAcetylcholinesterase(Homo sapiens (Human))TBA
LigandPNGBDBM50609388(CHEMBL5266165)
Affinity DataIC50:  300nMAssay Description:Inhibition of human AchE by Ellman's methodMore data for this Ligand-Target Pair
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TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50609389(CHEMBL5271833)
Affinity DataIC50:  310nMAssay Description:Inhibition of recombinant GSK-3beta (unknown origin) using GS peptide as substrate in presence of ATP incubated for 1 hrs by ADP-Glo kinase assayMore data for this Ligand-Target Pair
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TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))TBA
LigandPNGBDBM50609383(CHEMBL5284279)
Affinity DataIC50:  350nMAssay Description:Inhibition of recombinant human MAO-B assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate incubated for 20 mins by f...More data for this Ligand-Target Pair
Ligand Info
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TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50609390(CHEMBL5273659)
Affinity DataIC50:  450nMAssay Description:Inhibition of recombinant GSK-3beta (unknown origin) using GS peptide as substrate in presence of ATP incubated for 1 hrs by ADP-Glo kinase assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50609393(CHEMBL5270306)
Affinity DataIC50:  620nMAssay Description:Binding affinity to PPARgamma (unknown origin) by competitive binding assayMore data for this Ligand-Target Pair
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TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50609374(CHEMBL5274383)
Affinity DataIC50:  1.39E+3nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate incubated for 30 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTubulin beta chain(Sus scrofa)TBA
LigandPNGBDBM50609372(CHEMBL2018039)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization preincubated for 1 mins followed by GTP addition and measured for 60 mins at 1 min interval by flu...More data for this Ligand-Target Pair
Ligand Info
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LigandPNGBDBM50609369(CHEMBL144647)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization preincubated for 30 mins followed by GTP addition and measured after 20 mins by spectrophotometric ...More data for this Ligand-Target Pair
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))TBA
LigandPNGBDBM50609385(CHEMBL5283208)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) self aggregation by ThT-based fluorometric assayMore data for this Ligand-Target Pair
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TargetTubulin beta chain(Sus scrofa)TBA
LigandPNGBDBM50609371(CHEMBL3818930)
Affinity DataIC50:  1.99E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization preincubated for 1 mins followed by GTP addition and measured for 60 mins at 1 min interval by flu...More data for this Ligand-Target Pair
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TargetProteasome subunit beta type-8(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50099663(CHEMBL3319482)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human MM.1R cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50099663(CHEMBL3319482)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit OPM2 in human OPM1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50099663(CHEMBL3319482)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human OPM1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50099663(CHEMBL3319482)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human KMS12PE cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50099663(CHEMBL3319482)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human MM.1S cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50099663(CHEMBL3319482)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human RPMI8226 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50099663(CHEMBL3319482)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human LR5 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50099663(CHEMBL3319482)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human DOX40 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-8(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50099663(CHEMBL3319482)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of immunoproteasome subunit LMP7 in human INA60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50609373(CHEMBL1814434)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of Agaricus bisporus tyrosinase using L-DOPA as substrate incubated for 10 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
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TargetRetinoic acid receptor alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50609378(CHEMBL5287875)
Affinity DataIC50:  4.42E+3nMAssay Description:Antagonist activity at Gal4-RARalpha transfected in HEK293 cells assessed as atRA-induced RARalpha transactivation and measured after 6 hrs by Dual-L...More data for this Ligand-Target Pair
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TargetTubulin beta chain(Sus scrofa)TBA
LigandPNGBDBM50609370(CHEMBL3740269)
Affinity DataIC50:  7.56E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization preincubated for 1 mins followed by GTP addition and measured for 60 mins at 1 min interval by flu...More data for this Ligand-Target Pair
Ligand Info
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))TBA
LigandPNGBDBM50609385(CHEMBL5283208)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of self-induced amyloid beta (1 to 42) (unknown origin) disaggregation by ThT-based fluorometric assayMore data for this Ligand-Target Pair
Ligand Info
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TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50021475(CHEMBL3289941)
Affinity DataIC50:  8.12E+3nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition and measured after 1 mins by spec...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))TBA
LigandPNGBDBM50609376(CHEMBL5290692)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of PIM1 (unknown origin) using poly-Glu-Tyr (4:1) as substrate in presence of [gamma-33P-ATP] incubated for 2 hrs by radiometric kinase as...More data for this Ligand-Target Pair
Ligand Info
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