Affinity DataKi: 0.0530nMAssay Description:Displacement of [3H]PF-06883365 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0920nMAssay Description:Displacement of [125I]GLP-1 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:Inhibition of human Matrix metalloproteinase-9More data for this Ligand-Target Pair
Affinity DataKi: 0.570nMAssay Description:Displacement of [125I]-17 from human GLP-1R expressed in CHO cell membranes incubated for 120 mins by scintillation counting based radioligand bindin...More data for this Ligand-Target Pair
Affinity DataKi: 0.660nMAssay Description:Displacement of [125I]-17 from human GLP-1R expressed in CHO cell membranes incubated for 120 mins by scintillation counting based radioligand bindin...More data for this Ligand-Target Pair
Affinity DataKi: 0.690nMAssay Description:Inhibition of human Matrix metalloproteinase-9More data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Inhibition of human neutrophil collagenase, matrix metalloproteinase-8More data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of human Matrix metalloproteinase-9More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition of human Matrix metalloproteinase-9More data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Inhibition of human Matrix metalloproteinase-9More data for this Ligand-Target Pair
Affinity DataKi: <2nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
Affinity DataKi: <2nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
Affinity DataKi: <2nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
Affinity DataKi: <2nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
Affinity DataKi: 2nM ΔG°: -49.7kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of human neutrophil collagenase, matrix metalloproteinase-8More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibitory concentration of compound against human fibroblast stromelysin (HFS) was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of human neutrophil collagenase(HNC), MMP-8More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of human neutrophil collagenase(HNC), MMP-8More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of human neutrophil collagenase(HNC), MMP-8More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Inhibitory potency against human stromelysin, MMP-3More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of human neutrophil collagenase(HNC), MMP-8More data for this Ligand-Target Pair
Affinity DataKi: <2nMAssay Description:Inhibition of human neutrophil collagenase, matrix metalloproteinase-8More data for this Ligand-Target Pair
Affinity DataKi: <2nMAssay Description:Inhibition of human neutrophil collagenase, matrix metalloproteinase-8More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Inhibitory potency against human stromelysin, MMP-3More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibitory potency against human fibroblast collagenase, MMP-1More data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Inhibition of human Matrix metalloproteinase-9More data for this Ligand-Target Pair
Affinity DataKi: 3.60nM ΔG°: -48.2kJ/molepH: 7.4 T: 2°CAssay Description:Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...More data for this Ligand-Target Pair
Affinity DataKi: 3.80nMAssay Description:Inhibition of human Matrix metalloproteinase-9More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibition of human neutrophil collagenase, matrix metalloproteinase-8More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibition of human neutrophil collagenase(HNC), MMP-8More data for this Ligand-Target Pair
Affinity DataKi: 4.40nMAssay Description:Displacement of [125I]GLP-1 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.70nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Inhibitory potency against human stromelysin, MMP-3More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Inhibitory potency against human stromelysin, MMP-3More data for this Ligand-Target Pair
Affinity DataKi: 5.01nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Displacement of [125I]-17 from human GLP-1R expressed in CHO cell membranes incubated for 120 mins by scintillation counting based radioligand bindin...More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Inhibitory potency against human stromelysin, MMP-3More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Inhibitory potency against human stromelysin, MMP-3More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Inhibitory potency against human stromelysin, MMP-3More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Sterling Winthrop Pharmaceuticals Research Division
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloproteinase-3More data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:Displacement of [3H]PF-06883365 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibitory potency against human fibroblast collagenase, MMP-1More data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibition of human neutrophil collagenase, matrix metalloproteinase-8More data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibition of human neutrophil collagenase(HNC), MMP-8More data for this Ligand-Target Pair