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Found 379 with Last Name = 'matsubara' and Initial = 'k'
TargetProtein kinase C delta type(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50348877(CHEMBL1807163)
Affinity DataKi:  87nMAssay Description:Inhibition of [3H]PDBu binding to PKCdelta-C1B domain peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50348877(CHEMBL1807163)
Affinity DataKi:  360nMAssay Description:Inhibition of [3H]PDBu binding to PKCeta-C1B domain peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50348877(CHEMBL1807163)
Affinity DataKi:  480nMAssay Description:Inhibition of [3H]PDBu binding to PKCepsilon-C1B domain peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50348877(CHEMBL1807163)
Affinity DataKi:  600nMAssay Description:Inhibition of [3H]PDBu binding to PKCalpha-C1A domain peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C gamma type(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50348877(CHEMBL1807163)
Affinity DataKi:  660nMAssay Description:Inhibition of [3H]PDBu binding to PKCgamma-C1A domain peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Keio University

Curated by ChEMBL
LigandPNGBDBM50348877(CHEMBL1807163)
Affinity DataKi:  730nMAssay Description:Inhibition of [3H]PDBu binding to PKCbeta-C1A domain peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 2B1(Homo sapiens (Human))
Kanazawa University

Curated by ChEMBL
LigandPNGBDBM50248106(CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine)
Affinity DataKi:  8.48E+3nMAssay Description:Inhibition of OATP2B1-mediated [3H]estrone-3-sulfate uptake in human OATP2B1 expressing HEK293/PDZK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Kanazawa University

Curated by ChEMBL
LigandPNGBDBM50248106(CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine)
Affinity DataKi:  1.49E+4nMAssay Description:Inhibition of OATP1B1-mediated [3H]estrone-3-sulfate uptake in human OATP1B1 expressing HEK293/PDZK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
Kanazawa University

Curated by ChEMBL
LigandPNGBDBM50248106(CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine)
Affinity DataKi:  2.56E+4nMAssay Description:Inhibition of OATP1B3-mediated [3H]estradiol 17beta-glucuronide uptake in human OATP1B3 expressing HEK293/PDZK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
Kanazawa University

Curated by ChEMBL
LigandPNGBDBM50248106(CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine)
Affinity DataKi:  1.03E+5nMAssay Description:Inhibition of OCT1-mediated [14C]tetraethylammonium uptake in human OCT1 expressing HEK293/PDZK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510033(N-(2,4-dichloro-6-methyl- benzyl)-8-oxo-5,6,7,8- t...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510052(N-(2-chloro-3-(trifluoro methyl)benzyl)-8-oxo-5, 6...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510061(N-(2,4-dichloro-6-(hydroxy- methyl)benzyl)-8-oxo- ...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510097(N-(2,4-dichloro-6-methyl- benzyl)-8-hydroxy-5,6, 7...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510147(N-(2-chloro-3-(trifluoro methyl)benzyl)-8-hydroxy-...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510148(N-(2,3-dichlorobenzyl)- 8-hydroxy-5,6,7,8-tetra hy...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510149(N-(2,4-dichloro-6-(hydroxy- methyl)benzyl)-8-hydro...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510150(N-(2,4-dichloro-6-(methoxy- methyl)benzyl)-8-hydro...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510151(N-(2,4-dichloro-6-methyl- benzyl)-7-methylene- 6,7...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510152(N-(2,4-dichloro-6-methylbenzyl)-5- fluoro-8-oxo-5,...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510153(N-(2-chloro-3-(trifluoromethyl)benzyl)- 5-fluoro-8...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510154(N-(2,4-dichloro-6-(hydroxymethyl) benzyl)-5-fluoro...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510156(N-(2,4-dichloro-6-methylbenzyl)-7-oxo- 6,7-dihydro...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510158(N-(2,4-dichloro-6-methyl- benzyl)-5-fluoro-8-hydro...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510159(N-(2-chloro-3-(trifluoro- methyl)benzyl)-5-fluoro-...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510160(N-(2,4-dichloro-6-(hydroxy methyl)benzyl)-5-fluoro...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510161(N-(2,3-dichlorobenzyl)-5- fluoro-8-hydroxy-5,6,7,8...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510162(N-(2,4-dichlorobenzyl)-5- fluoro-8-hydroxy-5,6,7,8...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510163(N-(2,4-dichloro-6-(methoxy- methyl)benzyl)-5-fluor...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510164(N-(2,4-dichloro-6-methyl- benzyl)-5,8-dihydroxy-5,...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510166(N-(2,4-dichloro-6-methyl- benzyl)-7-hydroxy-6,7- d...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510167(N-(2-chloro-3-(trifluoro- methyl)benzyl)-7-hydroxy...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510169(N-(2,4-dichlorobenzyl)-5- fluoro-7-hydroxy-6,7-dih...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510170(2-(5-((2,4-dichloro-6-methyl- benzyl)carbamoyl)-5,...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510172((2-amino-2-oxoethyl)-N- (2-chloro-3-(trifluoro- me...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510173(N-(2,4-dichloro-6-methylbenzyl)-8-hy- droxy-8-(hyd...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510174(N-(2,4-dichloro-6-methylbenzyl)-5- fluoro-8-hydrox...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510175(N-(2-chloro-3-(trifluoromethyl)benzyl)- 5-fluoro-8...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510176(N-(2,3-dichlorobenzyl)-5-fluoro-8-hy- droxy-8-(hyd...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510177(N-(2,4-dichlorobenzyl)-5-fluoro-8-hy- droxy-8-(hyd...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM570506(N-(2,4-dichloro-6-meth- ylbenzyl)-5-fluoro-8-hy- d...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510180(N-(2-chloro-3-(tri- fluoromethyl)benzyl)- 5-fluoro...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510181((5S*,8S*)-N-(2,4- dichlorobenzyl)- 5-fluoro-8-hydr...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510182((5S*,8S*)-N-(2- chloro-4-fluoro- benzyl)-5-fluoro-...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510183(8-(aminomethyl)-N- (2,4-dichloro-6-meth- ylbenzyl)...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510184(N-(2,4-dichloro-6- methylbenzyl)-8- hydroxy-8-((me...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510185(8-(aminomethyl)- N-(2,4-dichloro-6- methylbenzyl)-...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510186(N-(2,4-dichloro-6- methylbenzyl)- 5-fluoro-8- hydr...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510187(N-(2,4-dichloro- 6-meth- ylbenzyl)-8-((dimeth- yla...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Raqualia Pharma

US Patent
LigandPNGBDBM510188(8-(aminomethyl)-N- (2-chloro-3-(trifluoro- methyl)...)
Affinity DataIC50: <50nMAssay Description:The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensitive fluorescent dy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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