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Found 641 with Last Name = 'mazzola' and Initial = 'r'
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM26524((1R,2S)-1-({3-fluoro-4-[(2-phenylquinolin-4-yl)met...)
Affinity DataKi:  0.140nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50292694((1R,2S)-1-(3-fluoro-4-((2-(pyridin-3-yl)quinolin-4...)
Affinity DataKi:  0.140nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50292693((1R,2S)-1-(3-fluoro-4-((2-(1-methyl-1H-pyrazol-3-y...)
Affinity DataKi:  0.150nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50292691((1R,2S)-1-(3-fluoro-4-((2-(pyrrolidin-1-yl)quinoli...)
Affinity DataKi:  0.150nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM26525((1S,2R)-1-N-hydroxy-2-({4-[(2-phenylquinolin-4-yl)...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50343977((2R,3R)-2,3-dihydroxy-4-(isoindolin-2-yl)-4-oxo-N-...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306314((R)-N-(4-(7-chloro-8-hydroxy-3-methyl-2,3,4,5-tetr...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50292690((1R,2S)-1-(3-fluoro-4-((2-morpholinoquinolin-4-yl)...)
Affinity DataKi:  0.210nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50292688((1S,2R)-N-hydroxy-2-((S)-3-hydroxypyrrolidine-1-ca...)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50292689((1R,2S)-N2-hydroxy-N1,N1-dimethyl-1-(4-((2-phenylq...)
Affinity DataKi:  0.280nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50292681((1S,2R)-N-hydroxy-2-((S)-2-(hydroxymethyl)pyrrolid...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50292682((1R,2S)-1-(3-fluoro-4-((2-phenylquinolin-4-yl)meth...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50292687((1S,2R)-2-((R)-3-(dimethylamino)pyrrolidine-1-carb...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306316((R)-N-(4-(7-chloro-8-hydroxy-3-methyl-2,3,4,5-tetr...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50343976((2R,3R)-2,3-dihydroxy-4-(isoindolin-2-yl)-N-((5-((...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306322(CHEMBL597909 | N-((6aS,13bR)-11-chloro-12-hydroxy-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306315((R)-N-(4-(7-chloro-8-hydroxy-3-methyl-2,3,4,5-tetr...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50292686((1S,2R)-2-((S)-3-(dimethylamino)pyrrolidine-1-carb...)
Affinity DataKi:  0.540nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065428(CHEMBL3401350)
Affinity DataKi:  0.600nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306317((R)-N-(4-(7-chloro-8-hydroxy-3-methyl-2,3,4,5-tetr...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50292685((1R,2S)-N2-hydroxy-1-(4-((2-phenylquinolin-4-yl)me...)
Affinity DataKi:  0.630nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306323(CHEMBL600986 | N-((6aS,13bR)-11-chloro-12-hydroxy-...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306325(1-((6aS,13bR)-11-chloro-12-hydroxy-7-methyl-6,6a,7...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50468037(CHEMBL4293298)
Affinity DataKi:  0.700nMAssay Description:Inhibition of recombinant human BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50468040(CHEMBL4289763)
Affinity DataKi:  0.700nMAssay Description:Inhibition of recombinant human BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306319((R)-5-(4-((benzyl(2,4-difluorophenyl)amino)methyl)...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50292692((1R,2S)-1-(3-fluoro-4-((2-(methylamino)quinolin-4-...)
Affinity DataKi:  0.760nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50342963((2R,3R)-N-((R)-1-(4-(1H-pyrazol-1-yl)phenyl)ethyl)...)
Affinity DataKi:  0.860nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306313((R)-8-chloro-5-(4-((cyclobutylamino)methyl)phenyl)...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50468048(CHEMBL4280271)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50398688(CHEMBL2178715)
Affinity DataKi:  1nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50398683(CHEMBL2178147)
Affinity DataKi:  1nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM23489((1R,2S)-2-N-hydroxy-1-N,1-N-dimethyl-1-({4-[(2-met...)
Affinity DataKi:  1nMAssay Description:Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50292695((1R,2S)-1-(4-((2-ethylquinolin-4-yl)methoxy)benzyl...)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50468039(CHEMBL4278329)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50468038(CHEMBL4294236)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50468047(CHEMBL4278011)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50468046(CHEMBL4278154)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50468043(CHEMBL4288838)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50468044(CHEMBL4279084)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50164512(CHEMBL3800286)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50449263(CHEMBL3125333)
Affinity DataKi:  1.10nMAssay Description:Antagonist activity at human CRTH2 receptor expressed in CHO-1 cells assessed as inhibition of PGD2-induced Ca2+ flux preincubated for 30 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306317((R)-N-(4-(7-chloro-8-hydroxy-3-methyl-2,3,4,5-tetr...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to dopamine D5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004823((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306334((6aS,13bR)-11-chloro-7-methyl-2-((4-(pyridin-2-yl)...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to dopamine D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM82247(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306326(CHEMBL603485 | ethyl(6aS,13bR)-11-chloro-12-hydrox...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50164512(CHEMBL3800286)
Affinity DataKi:  1.40nMAssay Description:Inhibition of recombinant human BACE1 preincubated for 30 mins followed QSY7EISEVNLDAEFC-Eu-amide substrate addition measured after 90 mins by FRET a...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306324(1-((6aS,13bR)-11-chloro-12-hydroxy-7-methyl-6,6a,7...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50449259(CHEMBL3125329)
Affinity DataKi:  1.60nMAssay Description:Antagonist activity at human CRTH2 receptor expressed in CHO-1 cells assessed as inhibition of PGD2-induced Ca2+ flux preincubated for 30 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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