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Found 169 with Last Name = 'mcbride' and Initial = 'hj'
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314782(CHEMBL1089866 | N-Cyclopropyl-3-(1-(2,4-difluoroph...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314785(CHEMBL1091929 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314778(3-(1-(2-Chlorophenyl)-7-methyl-6-oxo-6,7-dihydro-1...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314788(3-(1-(2,6-Difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314784(4-Chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314786(3-(1-(2,6-Difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314787(3-(1-(2,6-Difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314777(CHEMBL1089122 | N-Cyclopropyl-4-methyl-3-(7-methyl...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314781(CHEMBL1089534 | N-Cyclopropyl-3-(1-(2,5-difluoroph...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314792(1-(2,6-Difluorophenyl)-7-methyl-5-(6-methyl-3-(met...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314779(CHEMBL1089457 | N-Cyclopropyl-4-methyl-3-(7-methyl...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314780(CHEMBL1091199 | N-Cyclopropyl-3-(1-(2,4-difluoroph...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396616(CHEMBL2171930 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi:  3nMAssay Description:Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396610(CHEMBL2171929 | US8765940, 4-(3,3-dimethyl-6-(4-mo...)
Affinity DataKi:  7nMAssay Description:Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314783(CHEMBL1091927 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKi:  8nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396611(CHEMBL2171927 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi:  10nMAssay Description:Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396614(CHEMBL2171931 | US8765940, 1'-(7-fluoro-3-meth...)
Affinity DataKi:  11nMAssay Description:Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396616(CHEMBL2171930 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi:  18nMAssay Description:Inhibition of PI3Kbeta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396616(CHEMBL2171930 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi:  28nMAssay Description:Inhibition of PI3Kgamma by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396610(CHEMBL2171929 | US8765940, 4-(3,3-dimethyl-6-(4-mo...)
Affinity DataKi:  30nMAssay Description:Inhibition of PI3Kbeta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396614(CHEMBL2171931 | US8765940, 1'-(7-fluoro-3-meth...)
Affinity DataKi:  44nMAssay Description:Inhibition of PI3Kbeta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396611(CHEMBL2171927 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi:  54nMAssay Description:Inhibition of PI3Kbeta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396613(CHEMBL2171924 | US8765940, 1-(7-fluoro-3-methyl-2-...)
Affinity DataKi:  80nMAssay Description:Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396611(CHEMBL2171927 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi:  90nMAssay Description:Inhibition of PI3Kgamma by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396610(CHEMBL2171929 | US8765940, 4-(3,3-dimethyl-6-(4-mo...)
Affinity DataKi:  92nMAssay Description:Inhibition of PI3Kgamma by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396617(CHEMBL2171925 | US8765940, (1-(7-fluoro-3-methyl-2...)
Affinity DataKi:  154nMAssay Description:Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396617(CHEMBL2171925 | US8765940, (1-(7-fluoro-3-methyl-2...)
Affinity DataKi:  269nMAssay Description:Inhibition of PI3Kbeta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396615(CHEMBL2171928 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi:  364nMAssay Description:Inhibition of PI3Kgamma by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396613(CHEMBL2171924 | US8765940, 1-(7-fluoro-3-methyl-2-...)
Affinity DataKi:  395nMAssay Description:Inhibition of PI3Kbeta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396615(CHEMBL2171928 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi:  449nMAssay Description:Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314791(3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihyd...)
Affinity DataKi:  458nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396614(CHEMBL2171931 | US8765940, 1'-(7-fluoro-3-meth...)
Affinity DataKi:  509nMAssay Description:Inhibition of PI3Kgamma by ATP bioluminescence assayMore data for this Ligand-Target Pair
LigandPNGBDBM50396616(CHEMBL2171930 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi:  510nMAssay Description:Inhibition of PI3Kalpha by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396610(CHEMBL2171929 | US8765940, 4-(3,3-dimethyl-6-(4-mo...)
Affinity DataKi:  1.72E+3nMAssay Description:Inhibition of PI3Kalpha by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of p38deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396614(CHEMBL2171931 | US8765940, 1'-(7-fluoro-3-meth...)
Affinity DataKi:  3.25E+3nMAssay Description:Inhibition of PI3Kalpha by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of p38gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396611(CHEMBL2171927 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi:  3.54E+3nMAssay Description:Inhibition of PI3Kalpha by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396613(CHEMBL2171924 | US8765940, 1-(7-fluoro-3-methyl-2-...)
Affinity DataKi:  7.34E+3nMAssay Description:Inhibition of PI3Kgamma by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396613(CHEMBL2171924 | US8765940, 1-(7-fluoro-3-methyl-2-...)
Affinity DataKi: >1.25E+4nMAssay Description:Inhibition of PI3Kalpha by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396617(CHEMBL2171925 | US8765940, (1-(7-fluoro-3-methyl-2...)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of PI3Kgamma by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396615(CHEMBL2171928 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi: >1.25E+5nMAssay Description:Inhibition of PI3Kalpha by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396617(CHEMBL2171925 | US8765940, (1-(7-fluoro-3-methyl-2...)
Affinity DataKi: >1.25E+5nMAssay Description:Inhibition of PI3Kalpha by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396615(CHEMBL2171928 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi: >1.25E+5nMAssay Description:Inhibition of PI3Kbeta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326904(8-(2,4-Difluorophenyl)-3-(2,4-difluorophenylamino)...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of p38alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50296637(4-chloro-N-cyclopropyl-3-(1-(2,4-difluorophenyl)-7...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50326917(CHEMBL1254901 | N-Cyclopropyl-3-(8-(2,4-difluoroph...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of p38alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
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