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Found 135 with Last Name = 'mccoy' and Initial = 'ma'
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145828(2-(4-{3-[(S)-1-Carboxy-2-(4-hydroxy-3,5-diiodo-phe...)
Affinity DataKi:  800nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145844(2-(4-{3-[(S)-1-tert-Butoxycarbonyl-2-(4-hydroxy-3,...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB-cell CLL/lymphoma 9 protein(Homo sapiens)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity to N-terminal FLAG tagged beta catenin (134 to 671 residues)/FLAG tagged BCL9 domain 2 (343 to 396 residues) (unknown origin) protei...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCatenin beta-1(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50014132(CHEMBL2323032)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity to beta catenin ARD (142 to 686 residues) (unknown origin) assessed as inhibition constant by fluorescence polarisation assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145820(3-(4-Hydroxy-3,5-diiodo-phenyl)-propionic acid | C...)
Affinity DataKi:  8.00E+4nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145823(3-(4-Hydroxy-3,5-diiodo-phenyl)-3-phenyl-propionic...)
Affinity DataKi:  1.00E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145804(3-(4-Hydroxy-3,5-diiodo-phenyl)-2-phenyl-propionic...)
Affinity DataKi:  1.40E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145815(4-(4-Hydroxy-3,5-diiodo-phenyl)-butyric acid | CHE...)
Affinity DataKi:  1.80E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145808((R)-2-Acetylamino-3-(4-hydroxy-3,5-diiodo-phenyl)-...)
Affinity DataKi:  2.10E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145825((R)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-3,5-di...)
Affinity DataKi:  2.60E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145833((S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-3,5-di...)
Affinity DataKi:  3.10E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145835(4-Hydroxy-3,5-diiodo-benzoic acid | CHEMBL83650)
Affinity DataKi:  6.00E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50145827(CHEMBL311209 | N-[(4-methylbenzene)sulfonamido]ben...)
Affinity DataKi:  6.50E+5nMAssay Description:Inhibition constant for HCV NS3 protease substrate binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380310(CHEMBL2017619)
Affinity DataIC50:  90nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380309(CHEMBL2017463)
Affinity DataIC50:  100nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50362106(CHEMBL1938681)
Affinity DataIC50:  110nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380305(CHEMBL2017459)
Affinity DataIC50:  130nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380308(CHEMBL2017462)
Affinity DataIC50:  440nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380304(CHEMBL2017458)
Affinity DataIC50:  600nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380306(CHEMBL2017460)
Affinity DataIC50:  650nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380307(CHEMBL2017461)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor 4(Homo sapiens)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50556644(CHEMBL1214274 | NSC-45382)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of beta catenin/Tcf4 (8 to 30 reisdues) (unknown origin) incubated for 3 hrs by fluorescence polarisation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCatenin beta-1(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50589223(CHEMBL5185515)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant GST tagged beta catenin ARD by Alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380298(CHEMBL2017452)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor 4(Homo sapiens)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50589224(CHEMBL5173483)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of beta catenin/Tcf4 (unknown origin) protein protein interaction measured after 24 hrs by TOP-flash luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50362169(CHEMBL1938680)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 2 uM ATP by DELFIA a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50362169(CHEMBL1938680)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380291(CHEMBL2017445)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM51932(5-(4-chlorophenyl)-N-[4-(4-methyl-1-piperazinyl)ph...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380295(CHEMBL2017449)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380294(CHEMBL2017448)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50362169(CHEMBL1938680)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of human IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380302(CHEMBL2017456)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380290(CHEMBL2017444)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380288(CHEMBL2017442)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380300(CHEMBL2017454)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380301(CHEMBL2017455)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor 4(Homo sapiens)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50589221(CHEMBL5192638)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of beta catenin/recombinant GST tagged Tcf4 protein protein interaction in human HCT-116 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranscription factor 4(Homo sapiens)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50589220(CHEMBL3890384)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of beta catenin/recombinant GST tagged Tcf4 protein protein interaction in human HCT-116 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTranscription factor 4(Homo sapiens)
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50094484(CHEBI:3556 | CHEMBL2323033 | US9284299, CGP049090 ...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of beta catenin/recombinant GST tagged Tcf4 protein protein interaction in human HCT-116 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380303(CHEMBL2017457)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380299(CHEMBL2017453)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50362106(CHEMBL1938681)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes co-incubated with tolbutamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50362106(CHEMBL1938681)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes co-incubated with dextromethorphanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50362106(CHEMBL1938681)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes co-incubated with testosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380289(CHEMBL2017443)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50362106(CHEMBL1938681)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate incubated for 30 mins prior to substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50362106(CHEMBL1938681)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 30 mins prior to substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50362106(CHEMBL1938681)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes co-incubated with testosteroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380296(CHEMBL2017450)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of MK2 using Acam peptide as substrate incubated for 30 mins prior to substrate addition measured after 10 mins using 100 uM ATP by DELFIA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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