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Found 259 with Last Name = 'mcdonald' and Initial = 'ia'
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50246766(CHEMBL489079 | Mofegiline | US9302986, Mofegiline)
Affinity DataKi:  28nMAssay Description:Inhibition of human recombinant MAOB expressed in Pichia pastoris by kinetic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetp-hydroxybenzoate hydroxylase(Pseudomonas fluorescens)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50038194(2-Benzyloxy-4-hydroxy-benzoic acid | CHEMBL130259)
Affinity DataKi:  59nMAssay Description:Binding affinity of the compound against p-hydroxybenzoate hydroxylase (PHBH) from Pseudomonas fluorescence competing with p-hydroxy benzoic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetp-hydroxybenzoate hydroxylase(Pseudomonas fluorescens)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50038194(2-Benzyloxy-4-hydroxy-benzoic acid | CHEMBL130259)
Affinity DataKi:  69nMAssay Description:Binding affinity of the compound against p-hydroxybenzoate hydroxylase (PHBH) from Pseudomonas fluorescence competing with NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50246766(CHEMBL489079 | Mofegiline | US9302986, Mofegiline)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of human recombinant MAOA expressed in Pichia pastoris by kinetic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis

Curated by ChEMBL
LigandPNGBDBM50246766(CHEMBL489079 | Mofegiline | US9302986, Mofegiline)
Affinity DataKi:  1.61E+3nMAssay Description:Inhibition of human SSAO/VAP1 measuring H2O2 production by Kitz and Wilson plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis

Curated by ChEMBL
LigandPNGBDBM50384084(CHEMBL2029546)
Affinity DataKi:  1.64E+3nMAssay Description:Inhibition of human SSAO/VAP1 measuring H2O2 production by Kitz and Wilson plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50113840(4-Phenyl-butylamine | 4-phenylbutylamine | CHEMBL7...)
Affinity DataKi:  3.10E+4nMAssay Description:Inhibition of human MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004897((APV)2-Amino-5-phosphono-pentanoic acid | (R)-2-Am...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity towards AMPA receptor using [3H]AMPA as radioligand; InactiveMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50010893((R)-2-Amino-4-oxo-5-phosphono-pentanoic acid | 2-A...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity towards AMPA receptor using [3H]AMPA as radioligand; InactiveMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 3(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004897((APV)2-Amino-5-phosphono-pentanoic acid | (R)-2-Am...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity towards Ionotropic glutamate receptor kainate using [3H]-kainic acid as radioligand; InactiveMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 3(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50010893((R)-2-Amino-4-oxo-5-phosphono-pentanoic acid | 2-A...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity towards Ionotropic glutamate receptor kainate using [3H]-kainic acid as radioligand; InactiveMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 3(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50002363((APH)2-Amino-7-phosphono-heptanoic acid | 2-Amino-...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity towards Ionotropic glutamate receptor kainate using [3H]-kainic acid as radioligand; InactiveMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004927(4-Phosphonomethyl-piperidine-2-carboxylic acid | 4...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity towards AMPA receptor using [3H]AMPA as radioligand; InactiveMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 3(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50004927(4-Phosphonomethyl-piperidine-2-carboxylic acid | 4...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity towards Ionotropic glutamate receptor kainate using [3H]-kainic acid as radioligand; InactiveMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50002363((APH)2-Amino-7-phosphono-heptanoic acid | 2-Amino-...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity towards AMPA receptor using [3H]AMPA as radioligand; InactiveMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50002360((CPP)4-(3-Phosphono-propyl)-piperazine-2-carboxyli...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity towards AMPA receptor using [3H]AMPA as radioligand; InactiveMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 3(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50002360((CPP)4-(3-Phosphono-propyl)-piperazine-2-carboxyli...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity towards Ionotropic glutamate receptor kainate using [3H]-kainic acid as radioligand; InactiveMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-9(RAT)
Sibia Neurosciences

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataIC50:  2.40nMAssay Description:Binding affinity towards Nicotinic acetylcholine receptor by the displacement of [3H]-nicotine from rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50246766(CHEMBL489079 | Mofegiline | US9302986, Mofegiline)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of rat membrane MAOBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A/B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225462(CHEMBL554775)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against rat brain mitochondrial Monoamine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50246766(CHEMBL489079 | Mofegiline | US9302986, Mofegiline)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:Recombinant human MAO-B (0.06 mg/mL; Sigma Aldrich) was used as source of MAO-B enzyme activities. The assay was performed in a similar way as for hu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A/B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225466(CHEMBL544509)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against rat brain mitochondrial Monoamine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50213061(CHEMBL2298601)
Affinity DataIC50:  8.60nMAssay Description:Inhibitory activity of the compound against human prostatic Steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50246766(CHEMBL489079 | Mofegiline | US9302986, Mofegiline)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant MAO-B assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50384098(CHEMBL2029537)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant MAO-B assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A/B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225455(CHEMBL555332)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against rat brain mitochondrial Monoamine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis

Curated by ChEMBL
LigandPNGBDBM50384084(CHEMBL2029546)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant SSAO/VAP1 assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Mus musculus)
Pharmaxis

Curated by ChEMBL
LigandPNGBDBM50246766(CHEMBL489079 | Mofegiline | US9302986, Mofegiline)
Affinity DataIC50:  10nMAssay Description:Inhibition of SSAO/VAP1 in mouse adipocytes measuring H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A/B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225456(CHEMBL545207)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against rat brain mitochondrial Monoamine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis

Curated by ChEMBL
LigandPNGBDBM50384095(CHEMBL2029534)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant SSAO/VAP1 assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A/B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225453(CHEMBL541803)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against rat brain mitochondrial Monoamine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis

Curated by ChEMBL
LigandPNGBDBM50384083(CHEMBL2029545)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant SSAO/VAP1 assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis

Curated by ChEMBL
LigandPNGBDBM50246766(CHEMBL489079 | Mofegiline | US9302986, Mofegiline)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant SSAO/VAP1 assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A/B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM15579(CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against rat brain mitochondrial Monoamine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis

Curated by ChEMBL
LigandPNGBDBM50384087(CHEMBL2029549)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant SSAO/VAP1 assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50384094(CHEMBL2029533)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant MAO-B assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50384101(CHEMBL2029540)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant MAO-B assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis

Curated by ChEMBL
LigandPNGBDBM50384100(CHEMBL2029539)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant SSAO/VAP1 assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis

Curated by ChEMBL
LigandPNGBDBM50384088(CHEMBL2029550)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant SSAO/VAP1 assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis

Curated by ChEMBL
LigandPNGBDBM50384086(CHEMBL2029548)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant SSAO/VAP1 assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A/B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225463(CHEMBL538992)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against rat brain mitochondrial Monoamine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A/B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225449(CHEMBL543328)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity against rat brain mitochondrial Monoamine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50384097(CHEMBL2029536)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant MAO-B assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis

Curated by ChEMBL
LigandPNGBDBM50384098(CHEMBL2029537)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant SSAO/VAP1 assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane primary amine oxidase(Homo sapiens (Human))
Pharmaxis

Curated by ChEMBL
LigandPNGBDBM50384085(CHEMBL2029547)
Affinity DataIC50:  80nMAssay Description:Inhibition of human recombinant SSAO/VAP1 assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50384099(CHEMBL2029538)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant MAO-B assessed as H2O2 production by Resorufin/Amplex Red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM220884(US9302986, 18)
Affinity DataIC50: >100nMpH: 7.4 T: 2°CAssay Description:Recombinant human MAO-B (0.06 mg/mL; Sigma Aldrich) was used as source of MAO-B enzyme activities. The assay was performed in a similar way as for hu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM220869(US9302986, 2)
Affinity DataIC50: <100nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM220884(US9302986, 18)
Affinity DataIC50: <100nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM220861(US9302986, 4)
Affinity DataIC50: >100nMpH: 7.4 T: 2°CAssay Description:Recombinant human MAO-B (0.06 mg/mL; Sigma Aldrich) was used as source of MAO-B enzyme activities. The assay was performed in a similar way as for hu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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