BindingDB PrimarySearch_ki

Found 1487 with Last Name = 'mcgowan' and Initial = 'ma'

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50604026(CHEMBL5192384)

Ki: 0.110nMAssay Description:Displacement of [3H] labeled-N-(4-Fluorophenyl)-3-(4-(4-(2-hydroxypropan-2-yl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide from huma...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase PC cid PC sid

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50604023(CHEMBL5192977)

Ki: 0.150nMAssay Description:Displacement of [3H] labeled-N-(4-Fluorophenyl)-3-(4-(4-(2-hydroxypropan-2-yl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide from huma...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase PC cid PC sid PDB

Details PubMed PDB

3D Structure (crystal)

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50604021(CHEMBL5207194)

IC50: 0.0800nMAssay Description:Inhibition of IDO1 in IFNgamma/LPS stimulated human whole blood assessed as unbound concentration using kynurenine/tryptophan as substrate preincubat...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50538503(CHEMBL4645108)

IC50: 0.0900nMAssay Description:Inhibition of IDO1 in IFNgamma/LPS stimulated human whole blood assessed as unbound concentration using kynurenine/tryptophan as substrate preincubat...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50575884(CHEMBL4849371)

IC50: 0.200nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50604026(CHEMBL5192384)

IC50: 0.290nMAssay Description:Inhibition of IDO1 in IFNgamma/LPS stimulated human whole blood assessed as unbound concentration using kynurenine/tryptophan as substrate preincubat...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase PC cid PC sid

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50521218(CHEMBL4434674)

IC50: 0.330nMAssay Description:Inhibition of PI3KD (unknown origin) by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50568395(CHEMBL4848098)

IC50: 0.340nMAssay Description:Inhibition of human IDO1 assessed as unbound compound concentration by human whole blood assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50575901(CHEMBL4878995)

IC50: 0.400nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50568383(CHEMBL4872023)

IC50: 0.450nMAssay Description:Inhibition of human IDO1 assessed as unbound compound concentration by human whole blood assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50512300(CHEMBL4575012)

IC50: 0.5nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50570784(CHEMBL4873442)

IC50: 0.510nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50570790(CHEMBL4847971)

IC50: 0.540nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50543295(CHEMBL4642946)

IC50: 0.600nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells using L-tryptophan as substrate incubated for 48 hrs by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50568397(CHEMBL4869600)

IC50: 0.630nMAssay Description:Inhibition of human IDO1 assessed as unbound compound concentration by human whole blood assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50575891(CHEMBL4852541)

IC50: 0.700nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50570788(CHEMBL4877330)

IC50: 0.700nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50522155(CHEMBL4452905)

IC50: 0.700nMAssay Description:Inhibition of N-terminal His6 tagged recombinant full-length human PI3Kdelta/human recombinant full-length p85alpha expressed in baculovirus infected...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50575907(CHEMBL4878004)

IC50: 0.700nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50570783(CHEMBL4878320)

IC50: 0.740nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50575903(CHEMBL4858121)

IC50: 0.800nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50604025(CHEMBL5173861)

IC50: 0.800nMAssay Description:Inhibition of IDO1 in IFNgamma/LPS stimulated human whole blood assessed as unbound concentration using kynurenine/tryptophan as substrate preincubat...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50568391(CHEMBL4855740)

IC50: 0.840nMAssay Description:Inhibition of human IDO1 assessed as unbound compound concentration by human whole blood assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50548016(CHEMBL4787672)

IC50: 0.900nMAssay Description:Inhibition of N-terminal His6 tagged recombinant full-length human PI3Kdelta/human recombinant full-length p85alpha expressed in baculovirus infected...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50512313(CHEMBL4435694)

IC50: 0.900nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50570789(CHEMBL4852562)

IC50: 0.940nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50548015(CHEMBL4757468)

IC50: 0.980nMAssay Description:Inhibition of N-terminal His6 tagged recombinant full-length human PI3Kdelta/human recombinant full-length p85alpha expressed in baculovirus infected...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50522155(CHEMBL4452905)

IC50: 1nMAssay Description:Inhibition of PI3KD (unknown origin) by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50575902(CHEMBL4873843)

IC50: 1.20nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50604024(CHEMBL5193283)

IC50: 1.20nMAssay Description:Inhibition of IDO1 in IFNgamma/LPS stimulated human whole blood assessed as unbound concentration using kynurenine/tryptophan as substrate preincubat...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM334177((S)-(3-((9-ethyl-8-(6- (trifluoromethyl)pyridin-3-...)

IC50: 1.30nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50575900(CHEMBL4853960)

IC50: 1.30nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50575886(CHEMBL4853400)

IC50: 1.30nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50547993(CHEMBL4795757)

IC50: 1.30nMAssay Description:Inhibition of N-terminal His6 tagged recombinant full-length human PI3Kdelta/human recombinant full-length p85alpha expressed in baculovirus infected...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50570799(CHEMBL4863978)

IC50: 1.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50568383(CHEMBL4872023)

IC50: 1.40nMAssay Description:Inhibition of human IDO1 in human Hela cellsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50604025(CHEMBL5173861)

IC50: 1.5nMAssay Description:Inhibition of IDO1 in IFN gamma-stimulated human HeLa cells measured after 48 hrs by fluorescence based microplate reader assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50568387(CHEMBL4875994)

IC50: 1.60nMAssay Description:Inhibition of human IDO1 in human Hela cellsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50512302(CHEMBL4441262)

IC50: 1.60nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50575912(CHEMBL4859422)

IC50: 1.60nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50575908(CHEMBL4865449)

IC50: 1.60nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50512302(CHEMBL4441262)

IC50: 1.60nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50575911(CHEMBL4847079)

IC50: 1.70nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50538499(CHEMBL4638223)

IC50: 1.70nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells using L-tryptophan as substrate incubated for 48 hrs by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50538499(CHEMBL4638223)

IC50: 1.70nMAssay Description:Inhibition of heme binding to IDO1 in interferon-gamma-induced human HeLa cells assessed as reduction in N-formylkynurenine production using L-trypto...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50548006(CHEMBL4743715)

IC50: 1.70nMAssay Description:Inhibition of N-terminal His6 tagged recombinant full-length human PI3Kdelta/human recombinant full-length p85alpha expressed in baculovirus infected...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50570785(CHEMBL4852413)

IC50: 1.80nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Indoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Pharmaron Beijing

Curated by ChEMBL

PNG

BDBM50543291(CHEMBL4644751)

IC50: 1.90nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells using L-tryptophan as substrate incubated for 48 hrs by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase PC cid PC sid

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50547999(CHEMBL4744546)

IC50: 1.90nMAssay Description:Inhibition of N-terminal His6 tagged recombinant full-length human PI3Kdelta/human recombinant full-length p85alpha expressed in baculovirus infected...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck

Curated by ChEMBL

PNG

BDBM50575893(CHEMBL4866823)

IC50: 1.90nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Displayed 1 to 50 (of 1487 total ) | Next | Last >>

Filter my 1487 hits

Targets 266▿
- Indoleamine 2,3-dioxygenase 1 440
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 376
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 117
- Tryptophan 2,3-dioxygenase 52
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604] 39
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 31
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 31
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 30
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 23
- Potassium voltage-gated channel subfamily H member 2 14
- Cytochrome P450 2C9 8
- Tyrosine-protein kinase ABL1 5
- Epidermal growth factor receptor 5
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D 4
- Tyrosine-protein kinase JAK2 4
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B 4
- Voltage-dependent L-type calcium channel subunit alpha-1C 4
- cGMP-dependent 3',5'-cyclic phosphodiesterase 4
- Cytochrome P450 2D6 4
- Platelet-derived growth factor receptor alpha 4
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 4
- Sodium channel protein type 5 subunit alpha 4
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C 4
- Cytochrome P450 3A4 4
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 3
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 3
- cGMP-specific 3',5'-cyclic phosphodiesterase 3
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 3
- Proto-oncogene tyrosine-protein kinase receptor Ret 3
- Nuclear receptor subfamily 1 group I member 2 3
- O43924/P16499/P18545/P35913/P51160/Q13956 3
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B 3
- Cytochrome P450 2C8 3
- Receptor-type tyrosine-protein kinase FLT3 2
- Cytochrome P450 4B1 2
- Mast/stem cell growth factor receptor Kit 2
- Leucine-rich repeat serine/threonine-protein kinase 2 2
- Hepatocyte growth factor receptor 2
- Protein kinase C beta type 2
- Mitogen-activated protein kinase 10 2
- Mitogen-activated protein kinase 14 2
- Tyrosine-protein kinase Lyn 2
- Serine/threonine-protein kinase B-raf 2
- Cyclin-dependent kinase 5 activator 1 2
- Fibroblast growth factor receptor 3 2
- Serine/threonine-protein kinase haspin 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1 1
- Tyrosine-protein kinase JAK1 1
- Non-receptor tyrosine-protein kinase TYK2 1
- Glycogen synthase kinase-3 beta 1
- Calcium/calmodulin-dependent protein kinase type 1 1
- Protein kinase C iota type 1
- NUAK family SNF1-like kinase 1 1
- Calcium/calmodulin-dependent protein kinase type II subunit beta 1
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1
- Sphingosine kinase 1 1
- Serine/threonine-protein kinase PAK 1 1
- Protein kinase C theta type 1
- Serine/threonine-protein kinase PAK 2 1
- Serine/threonine-protein kinase PAK 3 1
- Dual specificity mitogen-activated protein kinase kinase 2 1
- Serine/threonine-protein kinase PAK 4 1
- Serine/threonine-protein kinase PAK 5 1
- Tyrosine-protein kinase JAK3 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Dual specificity mitogen-activated protein kinase kinase 6 1
- Sphingosine kinase 2 1
- Tyrosine-protein kinase ZAP-70 1
- Serine/threonine-protein kinase Sgk2 1
- Serine/threonine-protein kinase Sgk1 1
- Casein kinase I isoform gamma-3 1
- Casein kinase I isoform gamma-2 1
- Serine/threonine-protein kinase Sgk3 1
- Casein kinase I isoform epsilon 1
- Casein kinase I isoform gamma-1 1
- Ephrin type-A receptor 1 1
- Ephrin type-A receptor 3 1
- Ephrin type-A receptor 2 1
- Ephrin type-A receptor 5 1
- Tyrosine-protein kinase BTK 1
- Ephrin type-A receptor 4 1
- Tyrosine-protein kinase receptor UFO 1
- DNA-dependent protein kinase catalytic subunit 1
- Insulin-like growth factor 1 receptor 1
- Cyclin-A2/Cyclin-dependent kinase 2 1
- Myosin light chain kinase 2, skeletal/cardiac muscle 1
- Cytochrome P450 1A2 1
- Tyrosine-protein kinase Srms 1
- Phosphatidylinositol 3-kinase catalytic subunit type 3 1
- Focal adhesion kinase 1 1
- Tyrosine-protein kinase TXK 1
- Rhodopsin kinase GRK7 1
- Ephrin type-A receptor 8 1
- Phosphatidylinositol 4-kinase beta 1
- Death-associated protein kinase 1 1
- Serine/threonine-protein kinase D2 1
- Serine/threonine-protein kinase D3 1
- Serine/threonine-protein kinase D1 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1
- Death-associated protein kinase 3 1
- Serine/threonine-protein kinase pim-1 1
- Serine/threonine-protein kinase pim-2 1
- Testis-specific serine/threonine-protein kinase 1 1
- Protein kinase C epsilon type 1
- Testis-specific serine/threonine-protein kinase 2 1
- Protein-tyrosine kinase 6 1
- Casein kinase II subunit alpha 1
- Leukocyte tyrosine kinase receptor 1
- Cytoplasmic tyrosine-protein kinase BMX 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1
- Tyrosine-protein kinase ABL2 1
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 1
- cGMP-dependent protein kinase 2 1
- Rho-associated protein kinase 2 1
- cGMP-dependent protein kinase 1 1
- Rho-associated protein kinase 1 1
- Serine/threonine-protein kinase SIK2 1
- Tyrosine-protein kinase Fes/Fps 1
- 3-phosphoinositide-dependent protein kinase 1 1
- Mitogen-activated protein kinase 1 1
- Serine/threonine-protein kinase 3 1
- Mitogen-activated protein kinase 3 1
- Serine/threonine-protein kinase 4 1
- SRSF protein kinase 3 1
- Mitogen-activated protein kinase 9 1
- SRSF protein kinase 2 1
- Calcium/calmodulin-dependent protein kinase type IV 1
- Mitogen-activated protein kinase 8 1
- Tyrosine-protein kinase SYK 1
- Serine/threonine-protein kinase TBK1 1
- SRC kinase signaling inhibitor 1 1
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 1
- Vascular endothelial growth factor receptor 2 1
- Insulin receptor 1
- Tyrosine-protein kinase HCK 1
- Vascular endothelial growth factor receptor 3 1
- Vascular endothelial growth factor receptor 1 1
- Serine/threonine-protein kinase PLK1 1
- Serine/threonine-protein kinase PLK2 1
- Insulin receptor-related protein 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Serine/threonine-protein kinase PLK3 1
- Tyrosine-protein kinase receptor TYRO3 1
- Serine/threonine-protein kinase BRSK1 1
- Protein kinase C gamma type 1
- cAMP-dependent protein kinase catalytic subunit alpha 1
- Protein kinase C zeta type 1
- Eukaryotic elongation factor 2 kinase 1
- Serine/threonine-protein kinase Chk2 1
- Phosphatidylinositol 4-kinase alpha 1
- Serine/threonine-protein kinase Chk1 1
- cAMP-dependent protein kinase catalytic subunit PRKX 1
- SRSF protein kinase 1 1
- Tyrosine-protein kinase Yes 1
- Serine/threonine-protein kinase MRCK beta 1
- Cytochrome P450 2C19 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 4 1
- Casein kinase II subunit alpha' 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 3 1
- Receptor tyrosine-protein kinase erbB-4 1
- Receptor tyrosine-protein kinase erbB-2 1
- Tyrosine-protein kinase FRK 1
- Serine/threonine-protein kinase Nek9 1
- Serine/threonine-protein kinase Nek7 1
- Glycogen synthase kinase-3 alpha 1
- Serine/threonine-protein kinase Nek6 1
- Serine/threonine-protein kinase Nek4 1
- Serine/threonine-protein kinase Nek2 1
- Serine/threonine-protein kinase Nek1 1
- Macrophage-stimulating protein receptor 1
- MAP/microtubule affinity-regulating kinase 3 1
- Homeodomain-interacting protein kinase 4 1
- Homeodomain-interacting protein kinase 3 1
- MAP kinase-interacting serine/threonine-protein kinase 1 1
- MAP/microtubule affinity-regulating kinase 4 1
- Serine/threonine-protein kinase mTOR 1
- Tyrosine-protein kinase ITK/TSK 1
- Protein kinase C eta type 1
- Tyrosine-protein kinase Blk 1
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1
- Homeodomain-interacting protein kinase 2 1
- Homeodomain-interacting protein kinase 1 1
- Ribosomal protein S6 kinase beta-1 1
- Casein kinase I isoform delta 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Serine/threonine-protein kinase 26 1
- Serine/threonine-protein kinase 24 1
- Serine/threonine-protein kinase 25 1
- Ephrin type-B receptor 3 1
- Ephrin type-B receptor 4 1
- Ephrin type-B receptor 1 1
- Ephrin type-B receptor 2 1
- MAP kinase-activated protein kinase 3 1
- Platelet-derived growth factor receptor beta 1
- MAP kinase-activated protein kinase 5 1
- Muscle, skeletal receptor tyrosine-protein kinase 1
- Tyrosine-protein kinase Fer 1
- Calcium/calmodulin-dependent protein kinase type II subunit delta 1
- PAS domain-containing serine/threonine-protein kinase 1
- Proto-oncogene tyrosine-protein kinase ROS 1
- Beta-adrenergic receptor kinase 2 1
- Beta-adrenergic receptor kinase 1 1
- Serine/threonine-protein kinase DCLK2 1
- Serine/threonine-protein kinase TAO2 1
- Angiopoietin-1 receptor 1
- Mitogen-activated protein kinase kinase kinase kinase 2 1
- Serine/threonine-protein kinase MRCK alpha 1
- Mitogen-activated protein kinase kinase kinase kinase 4 1
- Mitogen-activated protein kinase kinase kinase kinase 5 1
- Activin receptor type-1B 1
- Interleukin-1 receptor-associated kinase 4 1
- Mitogen-activated protein kinase kinase kinase 9 1
- RAC-gamma serine/threonine-protein kinase 1
- Interleukin-1 receptor-associated kinase 1 1
- Mitogen-activated protein kinase kinase kinase 8 1
- RAC-alpha serine/threonine-protein kinase 1
- Megakaryocyte-associated tyrosine-protein kinase 1
- Proto-oncogene tyrosine-protein kinase Src 1
- BDNF/NT-3 growth factors receptor 1
- Cytochrome P450 2B6 1
- Tyrosine-protein kinase Lck 1
- Dual specificity protein kinase CLK1 1
- CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 1
- Protein kinase C delta type 1
- NT-3 growth factor receptor 1
- G protein-coupled receptor kinase 5 1
- G protein-coupled receptor kinase 4 1
- Dual specificity protein kinase CLK3 1
- Dual specificity protein kinase CLK2 1
- High affinity nerve growth factor receptor 1
- G protein-coupled receptor kinase 6 1
- Protein-tyrosine kinase 2-beta 1
- Tyrosine-protein kinase Mer 1
- Serine/threonine-protein kinase N1 1
- Ribosomal protein S6 kinase alpha-2 1
- Ribosomal protein S6 kinase alpha-3 1
- Ribosomal protein S6 kinase alpha-1 1
- Cyclin-T1/Cyclin-dependent kinase 9 1
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1
- Calcium/calmodulin-dependent protein kinase type 1D 1
- Fibroblast growth factor receptor 4 1
- Tyrosine-protein kinase Fgr 1
- Aurora kinase B 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1
- Aurora kinase A 1
- Fibroblast growth factor receptor 1 1
- Fibroblast growth factor receptor 2 1
- Aurora kinase C 1
- Mitogen-activated protein kinase 13 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 1
- Mitogen-activated protein kinase 12 1
- Mitogen-activated protein kinase 11 1
- RAC-beta serine/threonine-protein kinase 1
- Casein kinase I isoform alpha 1
- Misshapen-like kinase 1 1
- Tyrosine-protein kinase Fyn 1
- Tyrosine-protein kinase CSK 1
- Macrophage colony-stimulating factor 1 receptor 1
- Ribosomal protein S6 kinase alpha-6 1
- Protein kinase C alpha type 1
- Ribosomal protein S6 kinase alpha-4 1
- Maternal embryonic leucine zipper kinase 1
- Ribosomal protein S6 kinase alpha-5 1
- Serine/threonine-protein kinase MARK1 1
- Serine/threonine-protein kinase MARK2 1
- ...
Publications 17▿
- Bioorg Med Chem Lett 30: (2020) 314
- US Patent US10538497 (2020) 213
- Bioorg Med Chem Lett 42: (2021) 124
- J Med Chem 62: 4370-4382 (2019) 112
- J Med Chem 64: 5137-5156 (2021) 103
- US Patent US11230547 (2022) 99
- US Patent US10221178 (2019) 83
- US Patent US10501458 (2019) 72
- ACS Med Chem Lett 11: 2461-2469 (2020) 72
- ACS Med Chem Lett 10: 1530-1536 (2019) 52
- Bioorg Med Chem Lett 47: (2021) 51
- J Med Chem 65: 6001-6016 (2022) 41
- US Patent US11179389 (2021) 39
- US Patent US11096930 (2021) 36
- ACS Med Chem Lett 11: 1548-1554 (2020) 33
- Bioorg Med Chem Lett 29: 2575-2580 (2019) 31
- ACS Med Chem Lett 11: 550-557 (2020) 12
Institutions 5▿
- Merck 792
- Merck Sharp & Dohme 470
- TBA 112
- Iomet Pharma 72
- Pharmaron Beijing 41
Affinity: 0.080 to 6.0E+7 nM▿
- Ki 2
- IC50 1481
- Kd 1
- EC50 3
- Affinity ≤ nM
Xtal structures: 17
Docked structures: 0
Catalog Cmpds: 11