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Found 44 with Last Name = 'mcintyre' and Initial = 'g'
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50036132(15-chloromethyl-8-ethyl-8-hydroxy-(8S)-2,3,8,9,12,...)
Affinity DataIC50:  11nMAssay Description:Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50036129(14-chloromethyl-7-ethyl-7-hydroxy-(7S)-7,8,11,13-t...)
Affinity DataIC50:  15nMAssay Description:Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034013((S)-9-Bromo-4-ethyl-4-hydroxy-11-methyl-1,12-dihyd...)
Affinity DataIC50:  28nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034009((S)-4,11-Diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-te...)
Affinity DataIC50:  33nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034018((S)-4,11-Diethyl-4,N-dihydroxy-3,13-dioxo-3,4,12,1...)
Affinity DataIC50:  71nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50036133(7-ethyl-7-hydroxy-(7S)-7,8,11,13-tetrahydro-10H-[1...)
Affinity DataIC50:  78nMAssay Description:Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50049295(7-ethyl-7-hydroxy-14-(3-hydroxymethyl-1-pyridinium...)
Affinity DataIC50:  100nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034019((S)-9-Bromo-4,11-diethyl-4-hydroxy-1,12-dihydro-4H...)
Affinity DataIC50:  122nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50049303(7-ethyl-7-hydroxy-14-pyrazin-1-ium-1-ylmethyl-(7S)...)
Affinity DataIC50:  140nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034014((S)-4-Ethyl-4-hydroxy-11-methyl-3,13-dioxo-3,4,12,...)
Affinity DataIC50:  143nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50049304(7-ethyl-7-hydroxy-14-(1H-1-imidazolylmethyl)-(7S)-...)
Affinity DataIC50:  160nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034015((S)-9-Aminomethyl-4,11-diethyl-4-hydroxy-1,12-dihy...)
Affinity DataIC50:  167nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50049292(8-ethyl-8-hydroxy-15-pyrazin-1-ium-1-ylmethyl-(8S)...)
Affinity DataIC50:  180nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-I isolated from calf thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50049294(8-ethyl-8-hydroxy-15-(1-pyridiniumylmethyl)-(8S)-2...)
Affinity DataIC50:  190nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-I isolated from calf thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50049296(7-ethyl-7-hydroxy-14-pyridazin-1-ium-1-ylmethyl-(7...)
Affinity DataIC50:  190nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034020((S)-9-Aminomethyl-4-ethyl-4-hydroxy-11-methyl-8-ox...)
Affinity DataIC50:  190nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50049298(7-ethyl-7-hydroxy-14-(1H-imidazol-3-ium-3-ylmethyl...)
Affinity DataIC50:  200nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-I isolated from calf thymusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50049297(7-ethyl-7-hydroxy-14-(1-pyridiniumylmethyl)-(7S)-7...)
Affinity DataIC50:  210nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034024(((S)-4-Ethyl-4-hydroxy-11-methyl-3,13-dioxo-8-oxy-...)
Affinity DataIC50:  217nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50049299(7-ethyl-7-hydroxy-14-(3-methyl-1H-imidazol-3-ium-1...)
Affinity DataIC50:  220nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034010((S)-9-Aminomethyl-4-ethyl-4-hydroxy-11-methyl-1,12...)
Affinity DataIC50:  232nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50049293(8-ethyl-8-hydroxy-15-pyridazin-1-ium-1-ylmethyl-(8...)
Affinity DataIC50:  250nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034016((S)-4,11-Diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-te...)
Affinity DataIC50:  268nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50036131(7-ethyl-7-hydroxy-14-(4-methylhexahydro-1-pyraziny...)
Affinity DataIC50:  300nMAssay Description:Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034011((S)-4,11-Diethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6...)
Affinity DataIC50:  336nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50049302(8-ethyl-8-hydroxy-15-(4-hydroxymethyl-1-pyridinium...)
Affinity DataIC50:  340nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034030((S)-4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,8,12...)
Affinity DataIC50:  383nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50036130(8-ethyl-8-hydroxy-15-(4-methylhexahydro-1-pyraziny...)
Affinity DataIC50:  416nMAssay Description:Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034012((S)-9-(3-Amino-prop-1-ynyl)-4-ethyl-4-hydroxy-11-m...)
Affinity DataIC50:  505nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50049300(8-ethyl-8-hydroxy-15-(3-methyl-1H-imidazol-3-ium-1...)
Affinity DataIC50:  520nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50049301(8-ethyl-8-hydroxy-15-(3-hydroxymethyl-1-pyridinium...)
Affinity DataIC50:  600nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50008923((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...)
Affinity DataIC50:  679nMAssay Description:Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus)More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50008923((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...)
Affinity DataIC50:  700nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034025((S)-4,11-Diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-te...)
Affinity DataIC50:  949nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus)More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034017((S)-9-(3-Amino-prop-1-ynyl)-4,11-diethyl-4-hydroxy...)
Affinity DataIC50:  1.08E+3nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  1.08E+3nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  1.10E+3nMAssay Description:Average concentration of compound to cause 50% inhibition of topoisomerase-I isolated from calf thymusMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034029((S)-4-Ethyl-4-hydroxy-11-methyl-9-(3-morpholin-4-y...)
Affinity DataIC50:  1.11E+3nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034021((S)-4-Ethyl-4-hydroxy-8-oxy-1,12-dihydro-4H-2-oxa-...)
Affinity DataIC50:  1.18E+3nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034027((S)-9-(3-Dimethylamino-prop-1-ynyl)-4,11-diethyl-4...)
Affinity DataIC50:  1.33E+3nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034022((S)-4,11-Diethyl-4-hydroxy-8-methyl-3,13-dioxo-3,4...)
Affinity DataIC50:  1.46E+3nMAssay Description:Minimum concentration that produced 50% fragmentation of DNA was measured in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034028((S)-9-(3-Dimethylamino-propyl)-4,11-diethyl-4-hydr...)
Affinity DataIC50:  1.49E+3nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50034023((S)-4,11-Diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-te...)
Affinity DataIC50:  9.33E+3nMAssay Description:In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed