Compile Data Set for Download or QSAR
maximum 50k data
Found 44 with Last Name = 'mckee' and Initial = 'tc'
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50295171(AILANTHINONE | CHEMBL487194)
Affinity DataIC50:  32nMAssay Description:Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50349194(GLAUCARUBINONE | NSC-14975)
Affinity DataIC50:  40nMAssay Description:Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50295170(6R-senecionylchaparrin | CHEMBL564009)
Affinity DataIC50:  71nMAssay Description:Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50190657(CHEMBL1194747)
Affinity DataIC50:  730nMAssay Description:Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50190661(CHEMBL3901938)
Affinity DataIC50:  1.90E+3nMAssay Description:Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50190659(CHEMBL3912024)
Affinity DataIC50:  2.20E+3nMAssay Description:Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50190656(CHEMBL3910426)
Affinity DataIC50:  2.40E+3nMAssay Description:Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50269764((+)-Discorhabdin B | CHEMBL459120 | Discorhabdin A...)
Affinity DataIC50:  3.70E+3nMAssay Description:Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50352478(CHEMBL1823866)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of AP1 expressed in HEK293T cells coexpressing beta-lactamase pre-incubated 1 hr before TPA addition measured 18 hrs post TPA challenge by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Nci-Frederick

Curated by ChEMBL
LigandPNGBDBM50321556(8-hydroxy-5,10-dimethoxy-2-propyl-4H-benzo[h]chrom...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50352479(CHEMBL1823867)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of AP1 expressed in HEK293T cells coexpressing beta-lactamase pre-incubated 1 hr before TPA addition measured 18 hrs post TPA challenge by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50478416(CHEBI:65536 | CHEMBL444821)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50312636((-)-Makaluvamine F | CHEMBL509890 | Makaluvamine F)
Affinity DataIC50:  8.30E+3nMAssay Description:Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Nci-Frederick

Curated by ChEMBL
LigandPNGBDBM50221718(CHEMBL400538 | comaparvin)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Nci-Frederick

Curated by ChEMBL
LigandPNGBDBM50321557(5,8-dihydroxy-6,10-dimethoxy-2-methyl-4H-benzo[h]c...)
Affinity DataIC50:  1.19E+4nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50478415(Buchapine | CHEBI:65535)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Nci-Frederick

Curated by ChEMBL
LigandPNGBDBM50242177(5,8-dihydroxy-10-methoxy-2-methyl-4H-benzo[h]chrom...)
Affinity DataIC50:  1.28E+4nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Nci-Frederick

Curated by ChEMBL
LigandPNGBDBM50321555(6-methoxycomaparvin 5-methyl ether | CHEMBL256967)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Nci-Frederick

Curated by ChEMBL
LigandPNGBDBM50321558(6-methoxycomaparvin | CHEMBL401565)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50190660(CHEMBL3920971)
Affinity DataIC50:  3.52E+4nMAssay Description:Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50273917(CHEMBL462089 | Isolissoclinotoxin B)
Affinity DataIC50:  5.86E+4nMAssay Description:Inhibition of GST fused human Hdm2 assessed as polyubiquitylation by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50273972(CHEMBL461462 | Lissoclinidine B)
Affinity DataIC50:  5.86E+4nMAssay Description:Inhibition of GST fused human Hdm2 assessed as polyubiquitylation by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50190658(CHEMBL3938903)
Affinity DataIC50: >1.00E+5nMAssay Description:Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50273919(CHEMBL513108 | Diplamine B)
Affinity DataIC50:  1.01E+5nMAssay Description:Inhibition of GST fused human Hdm2 assessed as polyubiquitylation by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50273918(CHEMBL462090 | N,N-dimethyl-5-methylvaracin)
Affinity DataIC50:  1.21E+5nMAssay Description:Inhibition of GST fused human Hdm2 assessed as polyubiquitylation by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50240848(2-(3,4-Dimethoxy-5,6,7,8,9-pentathia-benzocyclohep...)
Affinity DataIC50: >2.95E+5nMAssay Description:Inhibition of GST fused human Hdm2 assessed as polyubiquitylation by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50240865((4aS,6aS,12aR,12bS)-10-Hydroxy-4,4,6a,12b-tetramet...)
Affinity DataEC50:  3.30E+3nMAssay Description:Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50398328(CHEMBL2177348)
Affinity DataEC50:  2.70E+3nMAssay Description:Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50398329(CHEMBL2177347)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50398330(XESTOQUINONE)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50398331(MIMOSAMYCIN)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter ge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50398327(VARIOLIN B)
Affinity DataEC50:  700nMAssay Description:Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50398326(CHEMBL2177349)
Affinity DataEC50:  1.48E+4nMAssay Description:Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50398325(CHEMBL2177350)
Affinity DataEC50:  8.70E+3nMAssay Description:Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50398324(CHEMBL510804)
Affinity DataEC50:  4.20E+3nMAssay Description:Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50398323(CHEMBL508487)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50398322(HETERONEMIN)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter ge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50356012(AAPTAMINE)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50340946((1R,3S,14S)-6,10,14-trimethyl-3-(prop-1-en-2-yl)-1...)
Affinity DataEC50:  1.08E+5nMAssay Description:Inhibition of HIF-2alpha activity in human 786-O cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50340947((6R,8S,18R)-3,8,12,16-Tetramethyl-7,18-dioxa-tricy...)
Affinity DataEC50:  1.83E+5nMAssay Description:Inhibition of HIF-2alpha activity in human 786-O cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50340951((1R,2S)-1-((1R,4aS,8S,11aR)-1-acetoxy-8-hydroperox...)
Affinity DataEC50:  1.18E+4nMAssay Description:Inhibition of HIF-2alpha activity in human 786-O cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50340948((1E,3E,7R*,8R*,11E)-1-(2-methoxypropan-2-yl)-4,8,1...)
Affinity DataEC50:  1.49E+5nMAssay Description:Inhibition of HIF-2alpha activity in human 786-O cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50340949((1R,2S)-1-((1R,4aS,11aR)-1-acetoxy-7-methyl-11-met...)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of HIF-2alpha activity in human 786-O cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50340950((1R,2S)-1-((1R,4aS,9R,11aR)-1-acetoxy-9-hydroxy-7-...)
Affinity DataEC50:  6.20E+3nMAssay Description:Inhibition of HIF-2alpha activity in human 786-O cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed