Affinity DataKi: 0.0400nMAssay Description:Agonistic activity of the compound towards retinoic acid receptor-gammaMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Centre For Addiction And Mental Health
Curated by ChEMBL
Centre For Addiction And Mental Health
Curated by ChEMBL
Affinity DataKi: 0.270nMAssay Description:In vitro binding affinity on cloned Serotonin transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Centre For Addiction And Mental Health
Curated by ChEMBL
Centre For Addiction And Mental Health
Curated by ChEMBL
Affinity DataKi: 0.330nMAssay Description:In vitro binding affinity on cloned Serotonin transporterMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Displacement of [3H]AVP from human vasopressin V1b receptor expressed in CHO cells by whole cell binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [3H]AVP from rat vasopressin V1b receptor expressed in CHO cells by whole cell binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Agonistic activity of the compound towards retinoic acid receptor-gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha [200-419]/gamma [183-417](Homo sapiens (Human))
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
Affinity DataKi: 1nM ΔG°: -47.8kJ/molepH: 8.0 T: 2°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha [200-419]/gamma [183-417](Homo sapiens (Human))
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
Affinity DataKi: 1nM ΔG°: -47.8kJ/molepH: 8.0 T: 2°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Centre For Addiction And Mental Health
Curated by ChEMBL
Centre For Addiction And Mental Health
Curated by ChEMBL
Affinity DataKi: 1.10nMAssay Description:In vitro binding affinity on cloned Serotonin transporterMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma [183-417](Homo sapiens (Human))
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
Affinity DataKi: 1.5nM ΔG°: -46.8kJ/molepH: 8.0 T: 2°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Centre For Addiction And Mental Health
Curated by ChEMBL
Centre For Addiction And Mental Health
Curated by ChEMBL
Affinity DataKi: 1.89nMAssay Description:In vitro binding affinity on cloned Serotonin transporterMore data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha [200-419](Homo sapiens (Human))
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
Affinity DataKi: 2nM ΔG°: -46.2kJ/molepH: 8.0 T: 2°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha [200-419](Homo sapiens (Human))
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
Affinity DataKi: 2.5nM ΔG°: -45.6kJ/molepH: 8.0 T: 2°CAssay Description:Competitive assay were perform with 5nM tritiated all-trans retinoic acid (t-RA; 5nM) with or without 100-fold excess of non-radioactive t-RA (500nM)...More data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Agonistic activity of the compound towards retinoic acid receptor-alphaMore data for this Ligand-Target Pair
Affinity DataKi: 3.60nMAssay Description:Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3.62nMAssay Description:Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3.80nMAssay Description:Agonistic activity of the compound towards retinoid X receptor-betaMore data for this Ligand-Target Pair
Affinity DataKi: 4.10nMAssay Description:Agonistic activity of the compound towards retinoic acid receptor-betaMore data for this Ligand-Target Pair
Affinity DataKi: 4.20nMAssay Description:Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.48nMAssay Description:Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.60nMAssay Description:Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 5.5nMAssay Description:Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 5.90nMAssay Description:Selective activity of the compound towards retinoid X receptor-betaMore data for this Ligand-Target Pair
Affinity DataKi: 6.5nMAssay Description:Agonistic activity of the compound towards retinoic acid receptor-alphaMore data for this Ligand-Target Pair
Affinity DataKi: 8.30nMAssay Description:Selective activity of the compound towards retinoid X receptor-gammaMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Agonistic activity of the compound towards retinoid X receptor-gammaMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Agonistic activity of the compound towards retinoid X receptor-alphaMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Selective activity of the compound towards retinoid X receptor-alphaMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Displacement of [3H]oxytocin from human oxytocin receptorMore data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Displacement of [3H]AVP from human vasopressin V1a receptor at 5 uMMore data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Displacement of [3H]MSX2 from adenosine A2A receptor in rat brain striatal membranesMore data for this Ligand-Target Pair
Affinity DataKi: 26.7nMAssay Description:Displacement of [3H]MSX2 from adenosine A2A receptor in rat brain striatal membranesMore data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 27.1nMAssay Description:Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Agonistic activity of the compound towards retinoic acid receptor-betaMore data for this Ligand-Target Pair
Affinity DataKi: 31.4nMAssay Description:Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 32.6nMAssay Description:Displacement of [3H]MSX2 from human recombinant adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 42nMAssay Description:Displacement of [3H]MSX2 from adenosine A2A receptor in rat brain striatal membranesMore data for this Ligand-Target Pair
Affinity DataKi: 45nMAssay Description:Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 50nMAssay Description:Selective activity of the compound towards retinoic acid receptor-betaMore data for this Ligand-Target Pair
Affinity DataKi: 53.4nMAssay Description:Displacement of [3H]ZM241385 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 53.8nMAssay Description:Displacement of [3H]PSB298 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 54nMAssay Description:Agonistic activity of the compound towards retinoid X receptor-betaMore data for this Ligand-Target Pair
Affinity DataKi: 54.8nMAssay Description:Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 64nMAssay Description:Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 75nMAssay Description:Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 93.7nMAssay Description:Displacement of [3H]MSX2 from adenosine A2A receptor in rat brain striatal membranesMore data for this Ligand-Target Pair