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Found 712 with Last Name = 'miao' and Initial = 'h'
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human full-length recombinant PARP-1More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM97563(US8470825, 4i)
Affinity DataKi:  50nMAssay Description:Inhibition of PARP-1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50601510(CHEMBL5170838)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))TBA
LigandPNGBDBM207624(US10501467, Example 69 | US9260440, 69 | US9617273...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of PARP-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033373(CHEMBL3357641)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033374(CHEMBL3357637)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033376(CHEMBL3357634)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50601479(CHEMBL5182746)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033384(CHEMBL3357639)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033375(CHEMBL3357635)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033394(CHEMBL3357644)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033381(CHEMBL3357642)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50427934(CHEMBL2322618)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of human recombinant PARP1 after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033380(CHEMBL3357643)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50594972(CHEMBL5177755)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of human recombinant PARP-1 (662 to 1011 residues)More data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50601508(CHEMBL5206652)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033396(CHEMBL3357636)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM207624(US10501467, Example 69 | US9260440, 69 | US9617273...)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033395(CHEMBL3357638)
Affinity DataIC50:  0.890nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  0.970nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50601511(CHEMBL5181979)
Affinity DataIC50:  1nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033382(CHEMBL3357640)
Affinity DataIC50:  1nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of mouse recombinant PARP-2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50536939(CHEMBL4569417)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human PARP-2 using histone as substrate incubated for 16 hrs by ELISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50536939(CHEMBL4569417)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human PARP-1 using histone as substrate incubated for 16 hrs by ELISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033391(CHEMBL3352869)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033374(CHEMBL3357637)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of wild type HER2 (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033377(CHEMBL3357649)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50427933(CHEMBL2323218)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant PARP1 after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))TBA
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of PARP-2 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50427929(CHEMBL2323222)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant PARP1 after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50354414(CHEMBL1836842)
Affinity DataIC50:  2nMAssay Description:Inhibition of BRK pretreated for 30 mins by microplate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033377(CHEMBL3357649)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50592663(CHEMBL5176961)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human recombinant PARP1 in presence of NAD+ by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50601501(CHEMBL5173723)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50601494(CHEMBL5192493)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033393(CHEMBL3357646)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033386(CHEMBL3357654)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033379(CHEMBL3357645)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50354415(CHEMBL1836854)
Affinity DataIC50:  3nMAssay Description:Inhibition of BRK pretreated for 30 mins by microplate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50354416(CHEMBL1836863)
Affinity DataIC50:  3nMAssay Description:Inhibition of BRK pretreated for 30 mins by microplate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50592669(CHEMBL5179564)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant PARP1 in presence of NAD+ by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50354432(CHEMBL1836844)
Affinity DataIC50:  3nMAssay Description:Inhibition of BRK pretreated for 30 mins by microplate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50354412(CHEMBL1836806)
Affinity DataIC50:  3nMAssay Description:Inhibition of BRK pretreated for 30 mins by microplate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033388(CHEMBL3357652)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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