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Found 2163 with Last Name = 'moradei' and Initial = 'om'
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM13934(Atazanavir | BMS 232632 | CGP 73547 | CHEMBL1163 |...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190623(CHEMBL3828743)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186595(US9168248, 22)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186602(US9168248, 75)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186593(US9168248, 17)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186592(US9168248, 16)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186594(US9168248, 18)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186597(US9168248, 42)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186596(US9168248, 28)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186603(US9168248, 76)
Affinity DataIC50:  1nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190638(CHEMBL3828119)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190625(CHEMBL3828552)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190624(CHEMBL3828417)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186600(US9168248, 68)
Affinity DataIC50:  3nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186577(US9168248, 1 | US9168248, 72)
Affinity DataIC50:  3nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190631(CHEMBL3828166)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190639(CHEMBL3827524)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190636(CHEMBL3828275)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190629(CHEMBL3828678)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190641(CHEMBL3827205)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190640(CHEMBL3828355)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190642(CHEMBL3827353)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190627(CHEMBL3827958)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)
Affinity DataIC50:  7nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)
Affinity DataIC50:  8nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190626(CHEMBL3827319)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)
Affinity DataIC50:  9nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190637(CHEMBL3827348)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190628(CHEMBL3827975)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186578(US9168248, 2)
Affinity DataIC50:  11nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190632(CHEMBL3827450)
Affinity DataIC50:  12nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186590(US9168248, 14)
Affinity DataIC50:  12nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186577(US9168248, 1 | US9168248, 72)
Affinity DataIC50:  12nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186587(US9168248, 11)
Affinity DataIC50:  13nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186579(US9168248, 3)
Affinity DataIC50:  13nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190630(CHEMBL3827960)
Affinity DataIC50:  14nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186591(US9168248, 15)
Affinity DataIC50:  17nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190633(CHEMBL3827407)
Affinity DataIC50:  20nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19412(CHEMBL235674 | benzamide-type inhibitor, 4 | pyrid...)
Affinity DataIC50:  20nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186598(US9168248, 46)
Affinity DataIC50:  21nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186589(US9168248, 13)
Affinity DataIC50:  24nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190634(CHEMBL3828494)
Affinity DataIC50:  27nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50190635(CHEMBL3827668)
Affinity DataIC50:  37nMAssay Description:Inhibition of wild-type HIV1 protease expressed in Escherichia coli assessed as reduction in product formation preincubated for 30 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataIC50:  40nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19421(4-{[(3,4-dimethoxyphenyl)amino]methyl}-N-[2-hydrox...)
Affinity DataIC50:  40nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186580(US9168248, 4)
Affinity DataIC50:  41nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Canada

US Patent
LigandPNGBDBM186581(US9168248, 5)
Affinity DataIC50:  49nMpH: 7.5Assay Description:The potency of compounds of formula I against the stearoyl-CoA desaturase was determined by measuring the conversion of radiolabeled stearoyl-CoA to ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19427(N-[2-amino-5-(thiophen-2-yl)phenyl]-4-methoxybenza...)
Affinity DataIC50:  50nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19414(N-[2-amino-5-(thiophen-2-yl)phenyl]-4-{[(3,4-dimet...)
Affinity DataIC50:  50nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19416(N-[2-amino-5-(thiophen-3-yl)phenyl]-4-{[(3,4-dimet...)
Affinity DataIC50:  50nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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