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Found 443 with Last Name = 'mousa' and Initial = 's'
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138318((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50:  0.180nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855((S)-2-Butoxycarbonylamino-3-{2-[(R)-3-(4-carbamimi...)
Affinity DataIC50:  0.25nMAssay Description:Inhbition of platelet aggregation in heparin treated human platelet rich plasma (PRP)More data for this Ligand-Target Pair
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855((S)-2-Butoxycarbonylamino-3-{2-[(R)-3-(4-carbamimi...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of [125I]fibrinogen binding to purified platelet Fibrinogen ReceptorMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50568278(CHEMBL4864932)
Affinity DataIC50:  0.300nMAssay Description:Binding affinity to integrin alphavbeta3 receptor (unknown origin) in presence of fibrinogen incubated for 2 hrs by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138313((5S,8S)-8-[(1H-Benzoimidazol-2-ylamino)-methyl]-3-...)
Affinity DataIC50:  0.390nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50568279(CHEMBL4869033)
Affinity DataIC50:  0.5nMAssay Description:Binding affinity to integrin alphavbeta3 receptor (unknown origin) in presence of fibrinogen incubated for 2 hrs by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073814(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  0.550nMAssay Description:Inhbition of platelet aggregation in heparin treated human platelet rich plasma (PRP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076575(3-{5-[4-amino(imino)methylaminobutyl]-4,5-dihydro-...)
Affinity DataIC50:  0.700nMAssay Description:Antagonistic activity against vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073819(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  0.860nMAssay Description:Inhibition of platelet aggregation in citrated human platelet rich plasma (PRP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50568280(CHEMBL4868199)
Affinity DataIC50:  1.10nMAssay Description:Binding affinity to integrin alphavbeta3 receptor (unknown origin) in presence of fibrinogen incubated for 2 hrs by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of fibrinogen (Fg) interaction with GPIIb/IIIa in gel filtered plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Fibrinogen Receptor integrin alphaIIb-beta3 in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073820(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  1.20nMAssay Description:Affinity for purified human platelet glycoprotein alpha IIb beta3 integrin receptor in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138321((5S,8S)-8-[(1H-Benzoimidazol-2-ylamino)-methyl]-3-...)
Affinity DataIC50:  1.40nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073818(2-(Bis-allyloxy-phosphorylamino)-3-{2-[3-(4-carbam...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of fibrinogen (Fg) interaction with GPIIb/IIIa in gel filtered plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073817(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of fibrinogen (Fg) interaction with GPIIb/IIIa in gel filtered plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217532(CHEMBL3559597)
Affinity DataIC50:  2nMAssay Description:Antagonistic activity against vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086630((1-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isox...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Platelet glycoprotein IIb/Platelet glycoprotein IIIa binding in unactivated human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086630((1-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isox...)
Affinity DataIC50:  2nMAssay Description:Inhibition of platelet aggregation in human platelet rich plasma (hPRP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083811(3-({1-[3-(1H-Imidazol-2-ylamino)-propyl]-1H-indazo...)
Affinity DataIC50:  2.30nMAssay Description:Inhbitory activity against beta3-transfected 293 cells using alpha-V beta-3 antagonism assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073815(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of fibrinogen (Fg) interaction with GPIIb/IIIa in gel filtered plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083839(2-Benzyloxycarbonylamino-3-({1-[3-(4,5-dihydro-1H-...)
Affinity DataIC50:  3.80nMAssay Description:Inhbition of Vitronectin receptor (alpha V beta 3) bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285198(CHEMBL67131 | [(5S,11S,14S)-21-Fluoro-11-(3-guanid...)
Affinity DataIC50:  4nMAssay Description:Inhibition of platelet aggregation using human platelet rich plasma (hPRP) assay (200microL, 2-3 x 10e 8 platelets/mL, n=1)More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  4nMAssay Description:Inhibition of platelet aggregation in human platelet rich plasma (hPRP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076582(3-{5-[4-amino(imino)methylaminobutyl]-4,5-dihydro-...)
Affinity DataIC50:  4nMAssay Description:Antagonistic activity against vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083766(2-(3,5-Dichloro-biphenyl-4-sulfonylamino)-3-({5-[4...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of vitronectin receptor (alpha V beta 3), expressed on human 293 cells, binding to immobilized fibrinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083823(3-({1-[3-(1H-Imidazol-2-ylamino)-propyl]-1H-indazo...)
Affinity DataIC50:  4.70nMAssay Description:Inhbitory activity against beta3-transfected 293 cells using alpha-V beta-3 antagonism assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083797(2-(3,5-Dimethyl-biphenyl-4-sulfonylamino)-3-({1-[3...)
Affinity DataIC50:  4.90nMAssay Description:Inhbitory activity against beta3-transfected 293 cells using alpha-V beta-3 antagonism assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285199(CHEMBL65617 | DMP-757 | [(5S,11S,14S)-11-(3-Guanid...)
Affinity DataIC50:  6nMAssay Description:Inhibition of platelet aggregation using human platelet rich plasma (hPRP) assay (200microL, 2-3 x 10e 8 platelets/mL, n=1)More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217533(CHEMBL3559598)
Affinity DataIC50:  7nMAssay Description:Antagonistic activity against fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083788(2-(2-Chloro-6-methyl-benzenesulfonylamino)-3-({5-[...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of vitronectin receptor (alpha V beta 3), expressed on human 293 cells, binding to immobilized fibrinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083803(2-Benzyloxycarbonylamino-3-({1-[3-(4,5-dihydro-1H-...)
Affinity DataIC50:  7.30nMAssay Description:Inhbition of Vitronectin receptor (alpha V beta 3) bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076576(3-{5-[4-amino(imino)methylaminobutyl]-4,5-dihydro-...)
Affinity DataIC50:  8nMAssay Description:Antagonistic activity against vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083836(2-(2,6-Dichloro-benzenesulfonylamino)-3-({1-[3-(1H...)
Affinity DataIC50:  8.5nMAssay Description:Inhbitory activity against beta3-transfected 293 cells using alpha-V beta-3 antagonism assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083789(2-(3,5-Dimethyl-biphenyl-4-sulfonylamino)-3-({5-[4...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of vitronectin receptor (alpha V beta 3), expressed on human 293 cells, binding to immobilized fibrinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50540953(CHEMBL4638793)
Affinity DataIC50:  10nMAssay Description:Binding affinity to purified integrin alphaVbeta3 receptor (unknown origin) incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50568277(CHEMBL4869261)
Affinity DataIC50:  10nMAssay Description:Binding affinity to integrin alphavbeta3 receptor (unknown origin) in presence of fibrinogen incubated for 2 hrs by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083837(2-(4-Chloro-benzenesulfonylamino)-3-({1-[3-(1H-imi...)
Affinity DataIC50:  10nMAssay Description:Inhbitory activity against beta3-transfected 293 cells using alpha-V beta-3 antagonism assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50237601(CHEMBL411941 | CycloRGDfV | [(2S,5R,8S,11S)-5-Benz...)
Affinity DataIC50:  10nMAssay Description:Inhibition of alphaV-beta3 interaction with vitronectinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083807(2-(3,4-Dichloro-benzenesulfonylamino)-3-({1-[3-(1H...)
Affinity DataIC50:  10nMAssay Description:Inhbitory activity against beta3-transfected 293 cells using alpha-V beta-3 antagonism assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50055896(3-{2-[3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxa...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [125I]fibrinogen binding to activated human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083810(2-(2,6-Dimethyl-benzenesulfonylamino)-3-({1-[3-(1H...)
Affinity DataIC50:  10nMAssay Description:Inhbitory activity against beta3-transfected 293 cells using alpha-V beta-3 antagonism assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083768((S)3-({5-[4-(1H-Imidazol-2-ylamino)-butyl]-4,5-dih...)
Affinity DataIC50:  10.6nMAssay Description:Inhibition of vitronectin receptor (alpha V beta 3), expressed on human 293 cells, binding to immobilized fibrinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083768((S)3-({5-[4-(1H-Imidazol-2-ylamino)-butyl]-4,5-dih...)
Affinity DataIC50:  10.6nMAssay Description:Inhibition of vitronectin receptor (alpha V beta 3), expressed on human 293 cells, binding to immobilized fibrinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50058855((S)-2-Butoxycarbonylamino-3-{2-[(R)-3-(4-carbamimi...)
Affinity DataIC50:  11nMAssay Description:Inhibition of [125I]fibrinogen binding to activated human plateletsMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076565(3-{5-[4-amino(imino)methylaminobutyl]-4,5-dihydro-...)
Affinity DataIC50:  11nMAssay Description:Antagonistic activity against fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076588(3-{5-[4-amino(imino)methylaminobutyl]-4,5-dihydro-...)
Affinity DataIC50:  12nMAssay Description:Antagonistic activity against vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083836(2-(2,6-Dichloro-benzenesulfonylamino)-3-({1-[3-(1H...)
Affinity DataIC50:  12nMAssay Description:Inhibition of aggregation of human gel-purified platelets (GPIIbIIIa GPP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076560(3-{5-[4-amino(imino)methylaminobutyl]-4,5-dihydro-...)
Affinity DataIC50:  12nMAssay Description:Antagonistic activity against fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50083812(3-({1-[3-(1H-Imidazol-2-ylamino)-propyl]-1H-indazo...)
Affinity DataIC50:  13nMAssay Description:Inhbitory activity against beta3-transfected 293 cells using alpha-V beta-3 antagonism assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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