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Found 182 with Last Name = 'mueller' and Initial = 'm'
Target3-oxoacyl-[acyl-carrier-protein] synthase 1 [C171Q](Mycobacterium tuberculosis)
University of Wuerzburg

LigandPNGBDBM214777(TLM18)
Affinity DataKi:  3.84E+5nMpH: 8.5Assay Description:Binding of TLM18 to wild-type and mutant KasA was quantified by monitoring changes in the intrinsic tryptophan fluorescence of the enzyme at waveleng...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3014(3-((3-Hydroxyphenyl)amino)-4-((3-chlorophenyl)amin...)
Affinity DataIC50:  1nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3023(3-{4-[(3-chlorophenyl)amino]-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  2nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3029(3-(4-Aminophenyl)-4-((3-chlorophenyl)amino)-1H-pyr...)
Affinity DataIC50:  2nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3027(3-(3-Aminophenyl)-4-((3-chlorophenyl)amino)-1H-pyr...)
Affinity DataIC50:  5nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3016(3-((4-Aminophenyl)amino)-4-((3-chlorophenyl)amino)...)
Affinity DataIC50:  5nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  6nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3025(3-(4-Hydroxyphenyl)-4-((3-chlorophenyl)amino)pyraz...)
Affinity DataIC50:  6nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3021(3-((4-Methoxybenzyl)amino)-4-((3-chlorophenyl)amin...)
Affinity DataIC50:  7nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3018(3-(Benzylamino)-4-((3-chlorophenyl)amino)-1H-pyraz...)
Affinity DataIC50:  7nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3012(3-((4-Hydroxyphenyl)amino)-4-((3-chlorophenyl)amin...)
Affinity DataIC50:  8nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3013(3-((3-Methoxyphenyl)amino)-4-((3-chlorophenyl)amin...)
Affinity DataIC50:  8nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3020(3-((3-Methoxybenzyl)amino)-4-((3-chlorophenyl)amin...)
Affinity DataIC50:  8nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3022(4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 23...)
Affinity DataIC50:  19nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3023(3-{4-[(3-chlorophenyl)amino]-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  26nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3019(3-((3-Chlorobenzyl)amino)-4-((3-chlorophenyl)amino...)
Affinity DataIC50:  26nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3017(3-((4-(Dimethylamino)phenyl)amino)-4-((3-chlorophe...)
Affinity DataIC50:  29nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3011(3-((4-Methoxyphenyl)-amino)-4-((3-chlorophenyl)ami...)
Affinity DataIC50:  30nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Novartis Pharmaceuticals

LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  30nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97610(CHEMBL1630715 | US8470841, 35)
Affinity DataIC50:  30nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3008(3,4-Bis((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]p...)
Affinity DataIC50:  33nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3026(3-(3-Nitrophenyl)-4-((3-chlorophenyl)amino)-1H-pyr...)
Affinity DataIC50:  37nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97601(US8470841, 17)
Affinity DataIC50:  50nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97600(US8470841, 12)
Affinity DataIC50:  50nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3006(3,4-Di-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidine ...)
Affinity DataIC50:  58nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97609(US8470841, 33)
Affinity DataIC50:  60nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97611(CHEMBL1630712 | US8470841, 36)
Affinity DataIC50:  70nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97623(US8470841, 52)
Affinity DataIC50:  80nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97622(CHEMBL1630701 | US8470841, 51)
Affinity DataIC50:  80nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3007(3-((3-Chlorophenyl)amino)-4-(phenylamino)-1H-pyraz...)
Affinity DataIC50:  84nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97615(US8470841, 44)
Affinity DataIC50:  90nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3024(3-(4-Methoxyphenyl)-4-((3-chlorophenyl)amino)-1H-p...)
Affinity DataIC50:  96nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM64583(BDBM50332551 | US8470841, 19)
Affinity DataIC50:  100nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97624(US8470841, 59)
Affinity DataIC50:  120nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3009(3-((3-Chlorophenyl)amino)-4-((3-bromophenyl)amino)...)
Affinity DataIC50:  130nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3010(3-((3-Chlorophenyl)amino)-4-((3-methylphenyl)amino...)
Affinity DataIC50:  130nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM50332552(CHEMBL1630708 | N-(4-(4-(5-(cyclopentyloxy)pyridin...)
Affinity DataIC50:  140nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97599(US8470841, 11)
Affinity DataIC50:  140nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97597(US8470841, 9)
Affinity DataIC50:  140nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97618(CHEMBL1630702 | US8470841, 47)
Affinity DataIC50:  150nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Novartis Pharmaceuticals

LigandPNGBDBM3012(3-((4-Hydroxyphenyl)amino)-4-((3-chlorophenyl)amin...)
Affinity DataIC50:  150nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97598(US8470841, 10)
Affinity DataIC50:  150nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3005(3-((3-Chlorophenyl)amino)-4-amino-1H-pyrazolo[3,4-...)
Affinity DataIC50:  160nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97621(US8470841, 50)
Affinity DataIC50:  170nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Sanofi

US Patent
LigandPNGBDBM97610(CHEMBL1630715 | US8470841, 35)
Affinity DataIC50:  170nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Novartis Pharmaceuticals

LigandPNGBDBM3023(3-{4-[(3-chlorophenyl)amino]-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  180nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM97610(CHEMBL1630715 | US8470841, 35)
Affinity DataIC50:  190nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM50332549((S)-N-(4-(4-(5-isopropoxypyridin-2-yloxy)phenyl)bu...)
Affinity DataIC50:  200nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2 [151-2458](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM50332555(CHEMBL1630705 | US8470841, 6 | trans-N-(3-(5-(4-(c...)
Affinity DataIC50:  200nMpH: 7.5 T: 2°CAssay Description:the enzymatic activity of ACC and its inhibition by test substances were determined by a luminometric assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3023(3-{4-[(3-chlorophenyl)amino]-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  200nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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