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Found 236 with Last Name = 'mullins' and Initial = 'pb'
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50078668(3-(4-Phenylsulfanyl-benzenesulfonyl)-cyclohexaneth...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-13 (hMMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50076589(3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol | CH...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-13 (hMMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196751(CHEMBL231862 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  1nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50078667(3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol | C...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-13 (hMMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574409(CHEMBL4873534)
Affinity DataIC50:  1.60nMAssay Description:Binding affinity to recombinant His-tagged ERalpha LBD (307 to 554 residue) (unknown origin) expressed in Escherichia coli preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196747(CHEMBL266566 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196755(CHEMBL266567 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196746(CHEMBL231861 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50076593(3-(4-Phenylsulfanyl-benzenesulfonyl)-propane-1-thi...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-13 (hMMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574409(CHEMBL4873534)
Affinity DataIC50:  2.10nMAssay Description:Binding affinity to ERalpha S463P mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196736(CHEMBL231863 | benzyl (S)-1-((2S,3R)-4-(3-ethylben...)
Affinity DataIC50:  3nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196745(CHEMBL414145 | methyl (S)-1-((2S,3R)-4-(3-ethylben...)
Affinity DataIC50:  3nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196749(CHEMBL394270 | pyridin-4-ylmethyl (S)-1-((2S,3R)-4...)
Affinity DataIC50:  3nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574409(CHEMBL4873534)
Affinity DataIC50:  3.20nMAssay Description:Binding affinity to ERalpha Y537S mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196757(CHEMBL391144 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50076589(3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol | CH...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-8 (hMMP-8)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196733(CHEMBL414776 | pyridin-3-ylmethyl (S)-1-((2S,3R)-4...)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196744(2,2,2-trifluoroethyl (S)-1-((2S,3R)-4-(3-ethylbenz...)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196754(CHEMBL393733 | methyl (S)-1-((2S,3R)-4-(3-ethylben...)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196752(CHEMBL412852 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196740(CHEMBL409875 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196734(CHEMBL409947 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574409(CHEMBL4873534)
Affinity DataIC50:  4.70nMAssay Description:Binding affinity to ERalpha D538G mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196739(CHEMBL266531 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  5nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196750(CHEMBL394271 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  5nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM15797((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-i...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant BACEMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196753(CHEMBL266565 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  5nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574413(CHEMBL4873959)
Affinity DataIC50:  5.30nMAssay Description:Binding affinity to recombinant His-tagged ERalpha LBD (307 to 554 residue) (unknown origin) expressed in Escherichia coli preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574412(CHEMBL4856006)
Affinity DataIC50:  6nMAssay Description:Binding affinity to ERalpha S463P mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50096851(CHEMBL3580774)
Affinity DataIC50:  6nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574401(CHEMBL4855559)
Affinity DataIC50:  7.20nMAssay Description:Binding affinity to ERalpha D538G mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574414(CHEMBL4850845)
Affinity DataIC50:  7.30nMAssay Description:Binding affinity to recombinant His-tagged ERalpha LBD (307 to 554 residue) (unknown origin) expressed in Escherichia coli preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574406(CHEMBL4851230)
Affinity DataIC50:  8nMAssay Description:Binding affinity to recombinant His-tagged ERalpha LBD (307 to 554 residue) (unknown origin) expressed in Escherichia coli preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Searle Discovery Research

Curated by ChEMBL
LigandPNGBDBM50078667(3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol | C...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant matrix metalloproteinase-8 (hMMP-8)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196758(2-cyanoethyl 1-((2S,3R)-4-(3-ethylbenzylamino)-1-(...)
Affinity DataIC50:  8nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574401(CHEMBL4855559)
Affinity DataIC50:  8.10nMAssay Description:Binding affinity to ERalpha Y537S mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574410(CHEMBL4851860)
Affinity DataIC50:  8.10nMAssay Description:Binding affinity to ERalpha Y537S mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574412(CHEMBL4856006)
Affinity DataIC50:  9.30nMAssay Description:Binding affinity to ERalpha D538G mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196731(CHEMBL231669 | N-{(S)-2-(butane-1-sulfonyl)-1-[(1S...)
Affinity DataIC50:  10nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196756(CHEMBL409949 | pyridin-3-ylmethyl (S)-1-((2S,3R)-4...)
Affinity DataIC50:  10nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196743(CHEMBL409950 | pyridin-4-ylmethyl (S)-1-((2S,3R)-4...)
Affinity DataIC50:  11nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574410(CHEMBL4851860)
Affinity DataIC50:  11nMAssay Description:Binding affinity to recombinant His-tagged ERalpha LBD (307 to 554 residue) (unknown origin) expressed in Escherichia coli preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196741((S)-N-((2S,3R)-4-(3-ethylbenzylamino)-1-(3,5-diflu...)
Affinity DataIC50:  13nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574413(CHEMBL4873959)
Affinity DataIC50:  14nMAssay Description:Binding affinity to ERalpha S463P mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574412(CHEMBL4856006)
Affinity DataIC50:  15nMAssay Description:Binding affinity to ERalpha Y537S mutant (unknown origin) expressed in Escherichia coli preincubated for 15 mins followed by ligand addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196737(CHEMBL409948 | S-tetrahydrofuran-3-yl (S)-1-((2S,3...)
Affinity DataIC50:  15nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196742(CHEMBL393140 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  15nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574401(CHEMBL4855559)
Affinity DataIC50:  15nMAssay Description:Binding affinity to recombinant His-tagged ERalpha LBD (307 to 554 residue) (unknown origin) expressed in Escherichia coli preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50574402(CHEMBL4878045)
Affinity DataIC50:  15nMAssay Description:Binding affinity to recombinant His-tagged ERalpha LBD (307 to 554 residue) (unknown origin) expressed in Escherichia coli preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50096863(CHEMBL3580766)
Affinity DataIC50:  17nMAssay Description:Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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