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Found 2279 with Last Name = 'mura' and Initial = 'e'
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511450(CHEMBL4436749)
Affinity DataKi:  0.00200nMAssay Description:Reversible inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511450(CHEMBL4436749)
Affinity DataKi:  0.00200nMAssay Description:Reversible inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50110121(3-[2-(2-{2-[2-(2-Acetylamino-3-carboxy-propionylam...)
Affinity DataKi:  0.0100nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50574769(CHEMBL4870603)
Affinity DataKi:  0.200nMAssay Description:Positive allosteric modulator activity in mouse kappa opioid receptor stably expressed in HEK293 cell membrane assessed as binding affinity of dyn A1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM214798(Dynorphin A (1-17) | YGGFLRRIRPKLK)
Affinity DataKi:  0.300nMAssay Description:Positive allosteric modulator activity in mouse kappa opioid receptor stably expressed in HEK293 cell membrane assessed as binding affinity of dyn A1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50574769(CHEMBL4870603)
Affinity DataKi:  0.300nMAssay Description:Positive allosteric modulator activity in mouse kappa opioid receptor stably expressed in HEK293 cell membrane assessed as binding affinity of dyn A1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50002184(CHEMBL415330 | H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-A...)
Affinity DataKi:  0.310nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50574769(CHEMBL4870603)
Affinity DataKi:  0.400nMAssay Description:Positive allosteric modulator activity in mouse kappa opioid receptor stably expressed in HEK293 cell membrane assessed as binding affinity of dyn A1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50574769(CHEMBL4870603)
Affinity DataKi:  0.400nMAssay Description:Positive allosteric modulator activity in mouse kappa opioid receptor stably expressed in HEK293 cell membrane assessed as binding affinity of dyn A1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50574769(CHEMBL4870603)
Affinity DataKi:  0.400nMAssay Description:Positive allosteric modulator activity in mouse kappa opioid receptor stably expressed in HEK293 cell membrane assessed as binding affinity of dyn A1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50110117(4-(2-Acetylamino-3-carboxy-propionylamino)-4-(1-{3...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  8.10nMAssay Description:Positive allosteric modulator activity in mouse kappa opioid receptor stably expressed in HEK293 cell membrane assessed as binding affinity of U50,48...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50574769(CHEMBL4870603)
Affinity DataKi:  10nMAssay Description:Positive allosteric modulator activity in mouse kappa opioid receptor stably expressed in HEK293 cell membrane assessed as binding affinity of U50,48...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50574769(CHEMBL4870603)
Affinity DataKi:  15nMAssay Description:Positive allosteric modulator activity in mouse kappa opioid receptor stably expressed in HEK293 cell membrane assessed as binding affinity of U50,48...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50574769(CHEMBL4870603)
Affinity DataKi:  15nMAssay Description:Positive allosteric modulator activity in mouse kappa opioid receptor stably expressed in HEK293 cell membrane assessed as binding affinity of U50,48...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50574769(CHEMBL4870603)
Affinity DataKi:  17nMAssay Description:Positive allosteric modulator activity in mouse kappa opioid receptor stably expressed in HEK293 cell membrane assessed as binding affinity of U50,48...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580697(CHEMBL5071625)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50574769(CHEMBL4870603)
Affinity DataKi:  36nMAssay Description:Positive allosteric modulator activity in mouse kappa opioid receptor stably expressed in HEK293 cell membrane assessed as binding affinity of U50,48...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50110125(2-[2-(2-{2-[2-(2-Acetylamino-3-carboxy-propionylam...)
Affinity DataKi:  40nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580681(CHEMBL5070568)
Affinity DataKi:  97nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580695(CHEMBL5077697)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580695(CHEMBL5077697)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580694(CHEMBL5091699)
Affinity DataKi:  170nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580693(CHEMBL5087018)
Affinity DataKi:  220nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580680(CHEMBL5070898)
Affinity DataKi:  220nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50480722(CHEMBL373691)
Affinity DataKi:  310nMAssay Description:Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580696(CHEMBL5088478)
Affinity DataKi:  650nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50574768(CHEMBL4848577)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]-DPN from mouse kappa opioid receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50574769(CHEMBL4870603)
Affinity DataKi:  2.00E+3nMAssay Description:Displacement of [3H]-DPN from mouse kappa opioid receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580691(CHEMBL5075196)
Affinity DataKi:  2.30E+3nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580683(CHEMBL5093924)
Affinity DataKi:  2.50E+3nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580682(CHEMBL5079877)
Affinity DataKi:  3.20E+3nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580690(CHEMBL5076021)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580692(CHEMBL5076587)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580684(CHEMBL5080221)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580689(CHEMBL5081959)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580697(CHEMBL5071625)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-diprenorphine from mouse MOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580697(CHEMBL5071625)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-diprenorphine from mouse DOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580685(CHEMBL5075574)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580686(CHEMBL5083929)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580687(CHEMBL5070737)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50580688(CHEMBL5087338)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataKi:  2.20E+4nMAssay Description:Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Medical University Of Vienna

Curated by ChEMBL
LigandPNGBDBM50124947(CHEMBL453539)
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]-diprenorphine from mouse KOR expressed in HEK293 cell membranes by radioligand binding assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511450(CHEMBL4436749)
Affinity DataIC50:  0.0430nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511453(CHEMBL4451394)
Affinity DataIC50: <0.0500nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511430(CHEMBL4455353)
Affinity DataIC50: <0.0500nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511431(CHEMBL4468099)
Affinity DataIC50: <0.0500nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511452(CHEMBL4570266)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50511454(CHEMBL4460228)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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