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Found 238 with Last Name = 'nielsen' and Initial = 'h'
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
University of Copenhagen

LigandPNGBDBM50088453(1-(6-Bromo-5-ethoxy-pyridin-3-yl)-[1,4]diazepane |...)
Affinity DataKi:  0.0670nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
University of Copenhagen

LigandPNGBDBM50143314((+)-Epibatidine | (-)-epibatidine | (1R,2R,4S)-2-(...)
Affinity DataKi:  0.0970nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
University of Copenhagen

LigandPNGBDBM50088453(1-(6-Bromo-5-ethoxy-pyridin-3-yl)-[1,4]diazepane |...)
Affinity DataKi:  0.25nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
University of Copenhagen

LigandPNGBDBM50088454(1-(6-Bromo-pyridin-3-yl)-[1,4]diazepane | 1-(6-bro...)
Affinity DataKi:  0.320nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
University of Copenhagen

LigandPNGBDBM50143314((+)-Epibatidine | (-)-epibatidine | (1R,2R,4S)-2-(...)
Affinity DataKi:  0.330nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50374600(CHEMBL272899)
Affinity DataKi:  0.560nMAssay Description:Displacement of [3H](+)-pentazocine from Sigma1 receptor in rat liver homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
University of Copenhagen

LigandPNGBDBM92377(NS3573, 2)
Affinity DataKi:  0.620nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
University of Copenhagen

LigandPNGBDBM50088438(1-(pyridin-3-yl)-1,4-diazepane | 1-Pyridin-3-yl-[1...)
Affinity DataKi:  0.720nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
University of Copenhagen

LigandPNGBDBM50088437(1-(5-Phenyl-pyridin-3-yl)-[1,4]diazepane | CHEMBL3...)
Affinity DataKi:  0.800nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
University of Copenhagen

LigandPNGBDBM86311(CAS_485-35-8 | Cytisine | Cytisine-(-) | NSC_22407...)
Affinity DataKi:  0.950nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50398057(CHEMBL2181924)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H](+)-pentazocine from Sigma1 receptor in rat liver homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50398057(CHEMBL2181924)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H](+)-pentazocine from Sigma1 receptor in rat liver homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
University of Copenhagen

LigandPNGBDBM50088454(1-(6-Bromo-pyridin-3-yl)-[1,4]diazepane | 1-(6-bro...)
Affinity DataKi:  1.30nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50374600(CHEMBL272899)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H](+)-pentazocine from Sigma1 receptor in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Homo sapiens (Human))
Stanford University

Curated by ChEMBL
LigandPNGBDBM50338990(1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piper...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to EBPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
University of Copenhagen

LigandPNGBDBM92377(NS3573, 2)
Affinity DataKi:  2.20nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
University of Copenhagen

LigandPNGBDBM50088438(1-(pyridin-3-yl)-1,4-diazepane | 1-Pyridin-3-yl-[1...)
Affinity DataKi:  3.10nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
Stanford University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H](+)-pentazocine from Sigma1 receptor in rat liver homogenateMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
Stanford University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H](+)-pentazocine from Sigma1 receptor in rat brain homogenateMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50211035((1S,2S,3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-a...)
Affinity DataKi:  4nMAssay Description:Displacement of [125I]RTI55 from human DAT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50211035((1S,2S,3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-a...)
Affinity DataKi:  4nMAssay Description:Inhibition of [3H]SER uptake in human SERT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50211035((1S,2S,3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-a...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]RTI55 from human SERT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
University of Copenhagen

LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)
Affinity DataKi:  6nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
University of Copenhagen

LigandPNGBDBM86311(CAS_485-35-8 | Cytisine | Cytisine-(-) | NSC_22407...)
Affinity DataKi:  8.20nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
University of Copenhagen

LigandPNGBDBM50088437(1-(5-Phenyl-pyridin-3-yl)-[1,4]diazepane | CHEMBL3...)
Affinity DataKi:  8.90nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50211035((1S,2S,3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-a...)
Affinity DataKi:  9nMAssay Description:Inhibition of [3H]DA uptake in human DAT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50211035((1S,2S,3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-a...)
Affinity DataKi:  10nMAssay Description:Inhibition of [3H]DA uptake in human NET expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
University of Copenhagen

LigandPNGBDBM50143314((+)-Epibatidine | (-)-epibatidine | (1R,2R,4S)-2-(...)
Affinity DataKi:  18nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50211035((1S,2S,3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-a...)
Affinity DataKi:  34nMAssay Description:Displacement of [125I]RTI55 from human NET expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50211042(CHEMBL388257 | ethyl 4-(naphthalen-2-yl)-1,2,5,6-t...)
Affinity DataKi:  79nMAssay Description:Displacement of [125I]RTI55 from human DAT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
University of Copenhagen

LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)
Affinity DataKi:  83nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
University of Copenhagen

LigandPNGBDBM50088438(1-(pyridin-3-yl)-1,4-diazepane | 1-Pyridin-3-yl-[1...)
Affinity DataKi:  136nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
University of Copenhagen

LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)
Affinity DataKi:  170nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50084717((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Affinity DataKi:  182nMAssay Description:Inhibition of [3H]DA uptake in human NET expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
University of Copenhagen

LigandPNGBDBM50088454(1-(6-Bromo-pyridin-3-yl)-[1,4]diazepane | 1-(6-bro...)
Affinity DataKi:  190nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50211003(CHEMBL243141 | ethyl 4-(3,4-dichlorophenyl)-1,2,5,...)
Affinity DataKi:  217nMAssay Description:Displacement of [125I]RTI55 from human SERT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50211042(CHEMBL388257 | ethyl 4-(naphthalen-2-yl)-1,2,5,6-t...)
Affinity DataKi:  268nMAssay Description:Displacement of [125I]RTI55 from human NET expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50193220((3S,4S)-methyl 4-(4-iodophenyl)-1-methylpiperidine...)
Affinity DataKi:  287nMAssay Description:Displacement of [125I]RTI55 from human SERT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
University of Copenhagen

LigandPNGBDBM86311(CAS_485-35-8 | Cytisine | Cytisine-(-) | NSC_22407...)
Affinity DataKi:  295nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50193220((3S,4S)-methyl 4-(4-iodophenyl)-1-methylpiperidine...)
Affinity DataKi:  323nMAssay Description:Displacement of [125I]RTI55 from human DAT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50084717((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Affinity DataKi:  347nMAssay Description:Inhibition of [3H]DA uptake in human DAT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50211042(CHEMBL388257 | ethyl 4-(naphthalen-2-yl)-1,2,5,6-t...)
Affinity DataKi:  440nMAssay Description:Displacement of [125I]RTI55 from human SERT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50211019(CHEMBL233088 | methyl 2-(3,4-dichlorophenyl)cycloh...)
Affinity DataKi:  515nMAssay Description:Inhibition of [3H]DA uptake in human DAT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50084717((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Affinity DataKi:  524nMAssay Description:Inhibition of [3H]SER uptake in human SERT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50211008(CHEMBL232870 | methyl 2-(4-chlorophenyl)cyclohex-1...)
Affinity DataKi:  589nMAssay Description:Inhibition of [3H]DA uptake in human DAT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50211029(CHEMBL395910 | methyl 2-(3,4-dichlorophenyl)cycloh...)
Affinity DataKi:  625nMAssay Description:Inhibition of [3H]DA uptake in human DAT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50084717((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Affinity DataKi:  630nMAssay Description:Displacement of [125I]RTI55 from human DAT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50211017(CHEMBL232299 | methyl 2-(biphenyl-4-yl)cyclohept-1...)
Affinity DataKi:  810nMAssay Description:Inhibition of [3H]DA uptake in human DAT expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
University of Copenhagen

LigandPNGBDBM50088453(1-(6-Bromo-5-ethoxy-pyridin-3-yl)-[1,4]diazepane |...)
Affinity DataKi:  847nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Aarhus

Curated by ChEMBL
LigandPNGBDBM50193220((3S,4S)-methyl 4-(4-iodophenyl)-1-methylpiperidine...)
Affinity DataKi:  855nMAssay Description:Displacement of [125I]RTI55 from human NET expressed in COS1 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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