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Found 292 with Last Name = 'nitta' and Initial = 'a'
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50276045((R)-3-Amino-4-(5-chloro-2-fluoro-phenyl)-N-{4-[6-(...)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50276047((R)-3-Amino-N-{4-[6-(2-morpholin-4-yl-ethoxy)-benz...)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50394470(CHEMBL2160099)
Affinity DataIC50:  0.870nMAssay Description:Antagonist activity at CCR3 receptor in human eosinophils assessed as inhibition of CCL11-induced degranulation after 4 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297172(CHEMBL560275 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Affinity DataIC50:  0.980nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50276001((R)-3-Amino-N-{4-[6-(2-methoxy-ethoxy)-benzothiazo...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297171(CHEMBL551735 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells by functional inhibition curve analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297181(2-[1-(1,3-Benzodioxol-5-ylcarbonyl)piperidin-4-yli...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50394470(CHEMBL2160099)
Affinity DataIC50:  1.70nMAssay Description:Antagonist activity at CCR3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297183(CHEMBL551738 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50276046((R)-3-amino-4-(5-chloro-2-fluorophenyl)-N-(4-(6-(2...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50394487(CHEMBL2160111)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity at CCR3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50275954((R)-3-Amino-N-[4-(6-methoxy-benzothiazol-2-yl)-1,1...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50275955((R)-3-Amino-N-[4-(5-methoxy-benzothiazol-2-yl)-1,1...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297177(CHEMBL561535 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430145(CHEMBL2338266)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297182(2-[1-(3,4-Dimethoxybenzoyl)piperidin-4-ylidene]-N-...)
Affinity DataIC50:  3.60nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50276044((3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430135(CHEMBL2338251)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297190(2-(1-Benzoylpiperidin-4-ylidene)-N-{(3R)-1-[(6-flu...)
Affinity DataIC50:  4.40nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297188(2-[1-(2-Fluorobenzoyl)piperidin-4-ylidene]-N-{(3R)...)
Affinity DataIC50:  4.80nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50387669(CHEMBL2058071)
Affinity DataIC50:  4.90nMAssay Description:Antagonist activity at human CCR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297180(CHEMBL556916 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297179(CHEMBL562923 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Affinity DataIC50:  5.10nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297185(CHEMBL556227 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Affinity DataIC50:  5.10nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430139(CHEMBL2338247)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297184(CHEMBL557118 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Affinity DataIC50:  5.80nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297174(2-[1-(4-Fluoro-2-hydroxybenzoyl)piperidin-4-yliden...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430136(CHEMBL2338250)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297173(2-[1-(4-Chloro-2-hydroxybenzoyl)piperidin-4-yliden...)
Affinity DataIC50:  7.5nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50401518(CHEMBL2206469)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of DPP4 in human Caco2 cell extracts using Ala-Pro-AFC as substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430140(CHEMBL2338246)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430132(CHEMBL2338254)
Affinity DataIC50:  8nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50387649(CHEMBL2057751)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at human CCR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430141(CHEMBL2338245)
Affinity DataIC50:  8nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297171(CHEMBL551735 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Affinity DataIC50:  8.40nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430147(CHEMBL2338264)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430147(CHEMBL2338264)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430134(CHEMBL2338252)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50394482(CHEMBL2159867)
Affinity DataIC50:  9.90nMAssay Description:Antagonist activity at CCR3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430142(CHEMBL2338244)
Affinity DataIC50:  10nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430138(CHEMBL2338248)
Affinity DataIC50:  11nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430137(CHEMBL2338249)
Affinity DataIC50:  11nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50394481(CHEMBL2159868)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at CCR3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50401519(CHEMBL2203319)
Affinity DataIC50:  12nMAssay Description:Inhibition of DPP4 in human Caco2 cell extracts using Ala-Pro-AFC as substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430148(CHEMBL2338263)
Affinity DataIC50:  12nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50264210(2-(Azepan-1-ylcarbonyl)-N-{(3-exo)-8-[(6-fluoro-2-...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50275905((R)-3-Amino-4-(2-fluoro-phenyl)-N-[4-(6-methoxy-be...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human Caco2 cells-derived DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297187((R)-2-(1-(3-fluorobenzoyl)piperidin-4-ylidene)-N-(...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430148(CHEMBL2338263)
Affinity DataIC50:  12nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50430140(CHEMBL2338246)
Affinity DataIC50:  13nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using cortisone and NADPH as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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