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Found 13475 with Last Name = 'no' and Initial = 'z'
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606735(CHEMBL5219718 | US11731973, Example 3)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606737(CHEMBL5218727 | US11731973, Example 5)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606738(CHEMBL5218590 | US11731973, Example 6)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606740(CHEMBL5220536 | US11731973, Example 30)
Affinity DataKi:  0.580nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606742(CHEMBL5220948 | US11731973, Example 9)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606739(CHEMBL5220152 | US11731973, Example 7)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606736(CHEMBL5218916 | US11731973, Example 10)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606741(CHEMBL5219710 | US11731973, Example 1)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606733(CHEMBL5218988)
Affinity DataKi:  2nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM582479(5-(2-aminobenzoxazol-5-yl)-7-methyl-7-methylsulfan...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606717(CHEMBL5218737)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to FKBP12 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606714(CHEMBL5220794)
Affinity DataKi:  4.20nMAssay Description:Binding affinity to FKBP12 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606713(CHEMBL5218786)
Affinity DataKi:  5.90nMAssay Description:Binding affinity to FKBP12 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606715(CHEMBL5219513)
Affinity DataKi:  6.5nMAssay Description:Binding affinity to FKBP12 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606716(CHEMBL5218757)
Affinity DataKi:  7.70nMAssay Description:Binding affinity to FKBP12 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606712(CHEMBL5219200)
Affinity DataKi:  7.90nMAssay Description:Binding affinity to FKBP12 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM582478(5-(2-aminobenzoxazol-5-yl)-7-isobutyl-6, 7-dihydro...)
Affinity DataKi:  12nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606734(CHEMBL5221072)
Affinity DataKi:  35nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetS-methylmethionine--homocysteine S-methyltransferase BHMT2(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50395382(CHEMBL2164724)
Affinity DataKi:  77nMAssay Description:Competitive inhibition of recombinant human BHMT2 expressed in Escherichia coli BL31(DE3) by Dixon plot method in presence of D,L-homocysteineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataKi:  5.40E+3nMAssay Description:Binding affinity to FKBP12 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50246899((S)-2-(3-((S)-1-carboxy-5-(4-iodobenzamido)pentyl)...)
Affinity DataIC50:  0.0210nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50088378(Afinitor | Afinitor Disperz | CHEBI:68478 | Everol...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468173(CHEMBL4284995)
Affinity DataIC50:  0.0750nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606717(CHEMBL5218737)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of mTORC1 in human Jurkat cells assessed as inhibition of S6K phosphorylation incubated for 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606703(CHEMBL5219040)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606702(CHEMBL5219001)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606701(CHEMBL5219477)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606700(CHEMBL5218941)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606699(CHEMBL5220295)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468167(CHEMBL4280968)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468163(CHEMBL4286872)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606736(CHEMBL5218916 | US11731973, Example 10)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of mTORC1 in human A-431 cells assessed as phosphorylated S6RP level incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606735(CHEMBL5219718 | US11731973, Example 3)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of mTORC1 in human A-431 cells assessed as phosphorylated S6RP level incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468164(CHEMBL4288368)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Uniwersytet Warszawski

US Patent
LigandPNGBDBM132084(US8841453, 15)
Affinity DataIC50:  0.240nMAssay Description:The biological activity of the compounds of general formula (I) towards the cholinesterase inhibition was evaluated using Ellman's method (Ellman, G....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCholinesterase(Homo sapiens (Human))
Uniwersytet Warszawski

US Patent
LigandPNGBDBM132071(US8841453, 1)
Affinity DataIC50:  0.25nMAssay Description:The biological activity of the compounds of general formula (I) towards the cholinesterase inhibition was evaluated using Ellman's method (Ellman, G....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCholinesterase(Homo sapiens (Human))
Uniwersytet Warszawski

US Patent
LigandPNGBDBM132080(US8841453, 11)
Affinity DataIC50:  0.25nMAssay Description:The biological activity of the compounds of general formula (I) towards the cholinesterase inhibition was evaluated using Ellman's method (Ellman, G....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCholinesterase(Homo sapiens (Human))
Uniwersytet Warszawski

US Patent
LigandPNGBDBM132083(US8841453, 14)
Affinity DataIC50:  0.280nMAssay Description:The biological activity of the compounds of general formula (I) towards the cholinesterase inhibition was evaluated using Ellman's method (Ellman, G....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468174(CHEMBL4277729)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606711(CHEMBL5220287)
Affinity DataIC50: >0.316nMAssay Description:Inhibition of mTORC1 in human PC-3 cells assessed as measuring phosphorylated S6K level incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606709(CHEMBL5219729)
Affinity DataIC50: >0.316nMAssay Description:Inhibition of mTORC1 in human PC-3 cells assessed as measuring phosphorylated S6K level incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606708(CHEMBL5220300)
Affinity DataIC50: >0.316nMAssay Description:Inhibition of mTORC1 in human PC-3 cells assessed as measuring phosphorylated S6K level incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606707(CHEMBL5220505)
Affinity DataIC50: >0.316nMAssay Description:Inhibition of mTORC1 in human PC-3 cells assessed as measuring phosphorylated S6K level incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606710(CHEMBL5219271)
Affinity DataIC50: >0.316nMAssay Description:Inhibition of mTORC1 in human PC-3 cells assessed as measuring phosphorylated S6K level incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468175(CHEMBL4291782)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCholinesterase(Homo sapiens (Human))
Uniwersytet Warszawski

US Patent
LigandPNGBDBM132074(US8841453, 4)
Affinity DataIC50:  0.380nMAssay Description:The biological activity of the compounds of general formula (I) towards the cholinesterase inhibition was evaluated using Ellman's method (Ellman, G....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50468177(CHEMBL4291245)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of recombinant human PSMA using [3H]NAAG as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606726(CHEMBL5220911)
Affinity DataIC50: <0.495nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606725(CHEMBL5220248)
Affinity DataIC50: <0.495nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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