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Found 66 with Last Name = 'nosjean' and Initial = 'o'
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340329(4-azamelatonin | CHEMBL1760944)
Affinity DataKi:  0.200nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.25nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340324(CHEMBL1760946 | N-(2-(6-Methoxy-1H-pyrrolo[2,3-b]p...)
Affinity DataKi:  0.280nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340329(4-azamelatonin | CHEMBL1760944)
Affinity DataKi:  0.300nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340338(CHEMBL1760947 | N-(2-(6-Methoxy-1H-pyrrolo[2,3-b]p...)
Affinity DataKi:  0.300nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.340nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340325(CHEMBL1760945 | N-(2-(6-Methoxy-1H-pyrrolo[2,3-b]p...)
Affinity DataKi:  0.600nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340327(CHEMBL1760957 | N-(2-(5,6,7,8-Tetrahydro-2-methoxy...)
Affinity DataKi:  0.680nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340338(CHEMBL1760947 | N-(2-(6-Methoxy-1H-pyrrolo[2,3-b]p...)
Affinity DataKi:  1.30nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340325(CHEMBL1760945 | N-(2-(6-Methoxy-1H-pyrrolo[2,3-b]p...)
Affinity DataKi:  1.40nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340324(CHEMBL1760946 | N-(2-(6-Methoxy-1H-pyrrolo[2,3-b]p...)
Affinity DataKi:  3.30nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340326(CHEMBL1760956 | N-(2-(3-iodo-6-methoxy-1H-pyrrolo[...)
Affinity DataKi:  5nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340327(CHEMBL1760957 | N-(2-(5,6,7,8-Tetrahydro-2-methoxy...)
Affinity DataKi:  9nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340326(CHEMBL1760956 | N-(2-(3-iodo-6-methoxy-1H-pyrrolo[...)
Affinity DataKi:  16nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340328(CHEMBL1760955 | N-(2-(6-methoxy-3-(2,2,2-trifluoro...)
Affinity DataKi:  30nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340330(7-azamelatonin | CHEMBL137969 | N-[2-(5-Methoxy-1H...)
Affinity DataKi:  40nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340328(CHEMBL1760955 | N-(2-(6-methoxy-3-(2,2,2-trifluoro...)
Affinity DataKi:  91nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340330(7-azamelatonin | CHEMBL137969 | N-[2-(5-Methoxy-1H...)
Affinity DataKi:  117nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340331(CHEMBL1760950 | N-(2-(6-methoxy-3-(piperidin-1-ylm...)
Affinity DataKi:  510nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340332(CHEMBL1760951 | N-(2-(6-methoxy-3-(morpholinomethy...)
Affinity DataKi:  550nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340331(CHEMBL1760950 | N-(2-(6-methoxy-3-(piperidin-1-ylm...)
Affinity DataKi:  742nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340333(CHEMBL1760952 | N-(2-(3-((4-(3-chlorophenyl)pipera...)
Affinity DataKi:  929nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340334(CHEMBL1760954 | N-(2-(6-methoxy-3-((methylamino)me...)
Affinity DataKi:  1.09E+3nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340333(CHEMBL1760952 | N-(2-(3-((4-(3-chlorophenyl)pipera...)
Affinity DataKi:  1.21E+3nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340335(CHEMBL1760949 | N-(2-(3-((benzyl(methyl)amino)meth...)
Affinity DataKi:  4.01E+3nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295298(CHEMBL552717 | icterogenin regioisomer)
Affinity DataKi:  5.30E+3nMAssay Description:Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295299(1-O-[alpha-L-(Rhamnopyranosyl]-23-acetoxy-3beta-ac...)
Affinity DataKi:  7.20E+3nMAssay Description:Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340336(CHEMBL1760953 | N-(2-(3-((4-(4-fluorobenzoyl)piper...)
Affinity DataKi:  7.44E+3nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295300(CHEMBL554122 | icterogenin)
Affinity DataKi:  7.60E+3nMAssay Description:Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340334(CHEMBL1760954 | N-(2-(6-methoxy-3-((methylamino)me...)
Affinity DataKi:  8.30E+3nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340336(CHEMBL1760953 | N-(2-(3-((4-(4-fluorobenzoyl)piper...)
Affinity DataKi:  9.49E+3nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340337(CHEMBL1760948 | N-(2-(3-((dimethylamino)methyl)-6-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340332(CHEMBL1760951 | N-(2-(6-methoxy-3-(morpholinomethy...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340337(CHEMBL1760948 | N-(2-(3-((dimethylamino)methyl)-6-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340335(CHEMBL1760949 | N-(2-(3-((benzyl(methyl)amino)meth...)
Affinity DataKi:  1.05E+4nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295162(CHEMBL556082 | Meiogynin A)
Affinity DataKi:  1.08E+4nMAssay Description:Displacement of fluorescent-tagged BH3 domain of Bak from Bcl-xL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295301(23-O-[alpha-L-(2',4'-Diacetylrhamnopyranosyl]imber...)
Affinity DataKi:  1.41E+4nMAssay Description:Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295302(23-acetoxy-3beta-acetylimberbic acid | CHEMBL53990...)
Affinity DataKi:  1.78E+4nMAssay Description:Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295163(1-epi-Meiogynin A | CHEMBL550027)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of fluorescent-tagged BH3 domain of Bak from Bcl-xL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295305(23-O-[alpha-L-(4'-Acetylrhamnopyranosyl]-3beta-ace...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295310(CHEMBL540988 | lantadene A)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295309(23-O-[alpha-L-(4'-Acetylrhamnopyranosyl]-3beta-ace...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295308(1-O-[alpha-L-(Rhamnopyranosyl]-23-acetoxy-3beta-ac...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295307(23-O-[alpha-L-(4'-acetylrhamnopyranosyl]imberbic a...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295306(1-O-[alpha-L-(Rhamnopyranosyl]-23-acetoxyimberbic ...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295303(23-Acetoxyimberbic acid 29-methyl ester | CHEMBL55...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295304(23-O-[alpha-L-(3',4'-Diacetylrhamnopyranosyl]-3bet...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50295311(CHEMBL555367 | lantadene B)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to Bcl-xL by fluorescein-labeled Bak-BH3 peptide competition binding assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340329(4-azamelatonin | CHEMBL1760944)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50340327(CHEMBL1760957 | N-(2-(5,6,7,8-Tetrahydro-2-methoxy...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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